Exploring the therapeutic potential of phenothiazine derivatives in medicinal chemistry

Results in Chemistry, Journal Year: 2024, Volume and Issue: 8, P. 101565 - 101565

Published: May 28, 2024

The phenothiazine analogs represent one of the privileged structures in medicinal chemistry and there has been an increasing number studies on phenothiazine-containing compounds. In this study, we report synthesis techniques including heterogeneous catalyst-assisted, microwave-assisted, ultrasound-assisted, combinatorial synthesis, as well using cyclization method, transition metal-catalyzed nanoparticle-mediated which have enhanced diversity potential applications unique scaffold also exhibits impressive antifungal, anticancer, antiprotozoal antioxidant therapies. Notably, phenothiazines demonstrate efficacy against various cancer cell lines microbial pathogens offers their therapeutic significance managing complex diseases such schizophrenia, cancer, infectious beyond role modulating neurotransmitter pathways. We examine structure–activity relationships, revealing how modifications to core influence pharmacological specificity. This review examines state art it relates comprehensive general summary different analogs, use starting building blocks multifarious architectures scales sufficient drive human drug trials. reports describing highly active compounds leads expectation that will further emerge a candidate field discovery.

Language: Английский

Dipeptide Tethered Sulphonamides as Anti-Diabetic, Anti-Inflammatory, and Anti-Oxidant Agent: Synthesis, Molecular Docking, and Drug-Likeness/ADMET Studies

Chemistry Africa, Journal Year: 2025, Volume and Issue: unknown

Published: April 16, 2025

Language: Английский

Synthesis, spectral characterizations, vibrational spectroscopy, DFT-computations, antibacterial, antioxidant, and molecular docking studies of the novel (Z)-2-(5-((10-hexyl-10H-phenothiazin-3-yl)methylene)-4-oxo-2-thioxothiazolidin-3-yl) acetic acid

Journal of Molecular Structure, Journal Year: 2023, Volume and Issue: 1292, P. 136008 - 136008

Published: June 20, 2023

Language: Английский