Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 12, 2024
Abstract
Coated
microneedles
(CMNs)
are
a
minimally
invasive
platform
for
immediate‐release
transdermal
drug
delivery.
However,
the
practical
applications
of
CMNs
have
been
significantly
hindered
by
challenges
associated
with
complex
formulations,
single
function,
and
limited
loading
capacity.
This
study
has
developed
spiderweb‐shaped
iron‐coordinated
polymeric
nanowire
network
(Fe‐IDA
NWs).
The
resulting
Fe‐IDA
NWs
endowed
certain
viscosity
due
to
synergy
multiple
supramolecular
interactions.
allows
them
replace
traditional
thickeners
as
microneedle
coatings.
NWs‐coated
MNs)
display
rapid
disintegration
in
skin
model,
which
also
enables
swift
diffusion
their
payloads
into
deeper
layers.
Additionally,
MNs
exhibit
desirable
enzymatic
activity
potential
antibacterial
ability.
Thus,
can
enhance
therapeutic
efficacy
against
wound
infection
through
synergistic
effects,
avoid
overly
complicated
formulation
release
nontherapeutic
molecules
conventional
CMNs.
As
proof‐of‐concept,
loaded
chlorin
e6
showed
chemodynamic‐photodynamic
effect
methicillin‐resistant
Staphylococcus
aureus‐infected
model
mice.
Collectively,
this
work
significant
implications
future
CMNs‐based
delivery
systems
expands
application
fields
metal
coordination
polymer
(MCP)
materials.
