One‐Pot Three‐Component Construction of 2,4‐Diarylbenzo[4,5] thieno[3,2‐d] pyrimidines Using Elemental Sulfur as a Sulfur Source DOI
Guorui Li, Fei Wen, Zheng Li

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(23)

Published: June 18, 2024

Abstract An efficient method for the construction of 2,4‐diarylbenzo[4,5]thieno[3,2‐ d ]pyrimidines through base‐promoted one‐pot three‐component tandem reactions o ‐nitrochalcones, benzamidine hydrochlorides, and elemental sulfur is described. The salient features this protocol are use cheap abundant source, readily available starting materials, transition‐metal‐free mild conditions, satisfactory yield, simple workup procedures. This transformation can also carry out on gram scale.

Language: Английский

Anti-breast cancer potential of thieno-pyrimidine derivatives as VEGFR-2 inhibitors DOI
Aisha A. Alsfouk, Maged Mohammed Saleh Al Ward, Mustafa A. Al-Qadhi

et al.

Future Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 16

Published: March 17, 2025

Background Thieno-pyrimidine derivatives have emerged as promising candidates for VEGFR-2 inhibition. This study aimed to design, synthesize, and evaluate novel thieno-pyrimidine their anti-cancer potential.

Language: Английский

Citations

0
A new antitumor platinum(II) complex containing metformin drug: synthesis, characterization, cellular responses, and theoretical study DOI
Neda Hosseinpour Moghadam, Sadegh Salehzadeh, Reza Kia

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142131 - 142131

Published: March 1, 2025

Language: Английский

Citations

0
Integrated in silico and in vitro discovery of a new anticancer thiadiazole analog targeting VEGFR-2 DOI
Ibrahim H. Eissa, Hazem Elkady, Walid E. Elgammal

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1312, P. 138641 - 138641

Published: May 15, 2024

Language: Английский

Citations

2
One‐Pot Three‐Component Construction of 2,4‐Diarylbenzo[4,5] thieno[3,2‐d] pyrimidines Using Elemental Sulfur as a Sulfur Source DOI
Guorui Li, Fei Wen, Zheng Li

et al.

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(23)

Published: June 18, 2024

Abstract An efficient method for the construction of 2,4‐diarylbenzo[4,5]thieno[3,2‐ d ]pyrimidines through base‐promoted one‐pot three‐component tandem reactions o ‐nitrochalcones, benzamidine hydrochlorides, and elemental sulfur is described. The salient features this protocol are use cheap abundant source, readily available starting materials, transition‐metal‐free mild conditions, satisfactory yield, simple workup procedures. This transformation can also carry out on gram scale.

Language: Английский

Citations

0