Cited by Fungicidal Activity of Novel 6-Isothiazol-5-ylpyrimidin-4-amine-Containing Compounds Targeting Complex I Reduced Nicotinamide Adenine Dinucleotide Oxidoreductase

4(3H)-Quinazolinone: A Natural Scaffold for Drug and Agrochemical Discovery DOI

Ke Chen,

Shumin Wang,

Shuyue Fu

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2473 - 2473

Published: March 10, 2025

4(3H)-quinazolinone is a functional scaffold that exists widely both in natural products and synthetic organic compounds. Its drug-like derivatives have been extensively synthesized with interesting biological features including anticancer, anti-inflammatory, antiviral, antimalarial, antibacterial, antifungal, herbicidal, etc. In this review, we highlight the medicinal agrochemical versatility of according to studies published past six years (2019–2024), comprehensively give summary target recognition, structure–activity relationship, mechanism its analogs. The present review expected provide valuable guidance for discovering novel lead compounds containing moiety drug research.

Language: Английский

Citations

Friedländer reactions for annulated pyrido[2,3-d]pyrimidines: Synthesis, structure characterization, anticancer and computational studies DOI

Al‐Shimaa Badran, Magdy A. Ibrahim,

Zeinab Hussain

et al.

Tetrahedron, Journal Year: 2025, Volume and Issue: unknown, P. 134608 - 134608

Published: March 1, 2025

Language: Английский

Citations

Nickel (II) Macrocyclic Complexes: Template Synthesis, Spectroscopic Investigations, Electrochemical Behavior, DFT Studies, and Biological Evaluation DOI

Manish Yadav,

Sarita Beniwal,

Gulshan Kumar

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(15)

Published: April 1, 2025

Abstract A novel series of tetraaza nickel (II) macrocyclic complexes was prepared via template condensation involving the ligand 2‐[4‐bromo‐2‐(2‐oxo‐1,2‐diphenyl‐ethylideneamino)‐phenylimino]‐1,2‐diphenyl‐ethanone (ML) and selected diamines, such as 4‐chloro 1,2‐phenylenediamine, 4‐bromo 1,2‐diaminotoluene, 4‐nitro 1,2‐diaminopropane, ethylenediamine, in presence NiCl 2 .6H O. The its resulting were characterized through elemental analysis, molecular weight determination, a range spectral techniques, including IR, electronic spectra, 1 H NMR, mass spectrometry, X‐ray powder diffraction, DFT‐assisted structural characterization. DFT (TDDFT/B3LYP/6–311g(d) method) analysis representative Ni(II) supports plausible structures proposed based on spectroscopic studies. These analyses suggest that each complex adopts six‐coordinated octahedral geometry. Their redox behavior examined detail using cyclic voltammetry (CV). Furthermore, new tested for their antimicrobial, antioxidant, antidiabetic, antituberculosis activities. Antimicrobial tests conducted against E. coli, B. subtilis, A. niger , P. chrysogenum synthesized compounds. antioxidant properties assessed DPPH assay showed [Ni(C 41 29 BrCl N 4 )] exhibited highest activity, with an IC 50 value 89.13 mg/mL. Additionally, antimycobacterial where 40 3 demonstrated significant effectiveness inhibiting growth Mycobacterium tuberculosis .

Language: Английский

Citations

Crystal structure, Hirshfeld surface analysis, molecular modeling, electrochemical properties, and potential medicinal activity of a novel binuclear Co(II) complex DOI

Walid M. Elsheemy,

Ayman A. Abdel Aziz, Ramadan M. Ramadan

et al.

Applied Organometallic Chemistry, Journal Year: 2024, Volume and Issue: 38(11)

Published: July 19, 2024

A quinoxaline‐based ligand, 6,7‐dimethyl‐2,3‐di(2‐pyridyl)quinoxaline (Me 2 dpq), and its unique binuclear Co(II)‐Me dpq complex were prepared analyzed using single crystal X‐ray diffraction several spectroscopy techniques. Hirshfeld surface analyses also used to clarify the Me ligand packing. The crystallized in triclinic P‐1 space group exhibited a distorted trigonal bipyramidal geometry around cobalt(II) ion. Each Co(II) ion coordinated through two N donor centers from pyridyl quinoxaline rings along with terminal Cl bridged atoms. binding properties of CT‐DNA studied by techniques, namely UV–Vis spectroscopy, fluorescence quenching, viscosity measurements, thermal denaturation, gel electrophoresis. interaction tests demonstrated that both parent bind DNA an intercalative way. antioxidant studies novel illustrated significant activity against DPPH • radicals. vitro cytotoxic effect Co(II)‐complex on MCF‐7 Hep‐G2 tumor cell lines was evaluated MTT assay. showed had superior toward tested lines. Molecular docking synthesized compounds employed figure out way they would associate biologically macromolecular target B‐DNA (PDB: 1BNA). Thus, this study is anticipated provide opportunities for successful utilization many medical domains.

Language: Английский

Citations

Fungicidal Activity of Novel 6-Isothiazol-5-ylpyrimidin-4-amine-Containing Compounds Targeting Complex I Reduced Nicotinamide Adenine Dinucleotide Oxidoreductase DOI

Kun Li, You Lv,

Rongzhang Wu

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 25, 2024

To discover novel inhibitors of the complex I reduced nicotinamide adenine dinucleotide (NADH) oxidoreductase as fungicides, a series 6-isothiazol-5-ylpyrimidin-4-amine-containing compounds were designed using computer-aided pesticide design method and splicing substructures from diflumetorim isotianil. In vitro fungicidal bioassays indicated that

Language: Английский

Citations