A rapid, efficient microwave-assisted synthesis of novel bis-pyrazole analogues using non-toxic and cost-effective catalyst under green solvent medium DOI

Komati Satish Kumar,

Alice R. Robert,

Adapaka Venkateswara Rao

et al.

Chemical Data Collections, Journal Year: 2024, Volume and Issue: unknown, P. 101165 - 101165

Published: Sept. 1, 2024

Language: Английский

A tandem approach for the synthesis of 1-phenyl-pyrazolo-quinolinones by Fe 3 O 4 @MWCNT nanocomposite as heterogeneous catalyst DOI Creative Commons

Adapaka Venkateswara Rao,

Suresh Maddila, Nagaraju Kerru

et al.

Green Chemistry Letters and Reviews, Journal Year: 2025, Volume and Issue: 18(1)

Published: Jan. 10, 2025

A simple, facile, efficient and highly promising protocol for the synthesis of 1-phenyl-pyrazolo-quinolinone analogs using Fe3O4@MWCNT nano-composite as a catalyst via Knoevenagel–Michael reaction has been developed. The use several advantages, like simple preparation, inexpensive, handling, high stability. It was synthesized from MWCNT iron oxide thoroughly characterized BET, PXRD, SEM, TEM, TGA analysis. All target molecules were confirmed by various spectroscopic techniques such 1H-NMR, 15N-NMR, 13C-NMR, HRMS. present work unveils environmentally friendly approach synthesizing phenyl-pyrazolo-quinolinone scaffolds with higher yields (93–97%), selectivity, efficiency, mild conditions, no need chromatographic separation, short times, recovery reuse minimum seven cycles is possible without causing notable reduction in product yields. method complies green chemistry principles presents feasible alternative to previously documented techniques.

Language: Английский

Citations

0
Exploration of 1,3,4‐oxadiazoles Engrafted With Indole and Phthalimide Scaffolds as Multi Target Peroxidase, Acetylcholinesterase, and Butyrylchloinesterase Inhibitors: Synthesis, DFT Calculations, and Molecular Docking Studies DOI Open Access

B. Jaishree,

S. M. Basavarajaiah, Prashantha Karunakar

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(6)

Published: Feb. 1, 2025

Abstract Here, we present the structural and pharmacological characteristics of 2‐(4‐(5‐(3,5‐disubstituted‐1 H ‐indol‐2‐yl)‐1,3,4‐oxadiazol‐2‐yl)phenyl)isoindoline‐1,3‐diones 5(a‐h) as a strong antioxidant anti‐Alzheimer's disease activity using synergistic combination theoretical experimental techniques. The structures novel compounds were analyzed by spectral analysis (IR, NMR Mass spectrometry). DFT calculations for selected applying B3LYP hybrid functional 6–31G (d, p) basis set. predictions regarding ADMET properties, drug‐likeness, toxicity, including favorable bioavailability all synthesized disclosed. All newly 5(a–h) illustrated well to comparable inhibitory potentials ranging from IC 50 values 12.12 ± 0.02 µM 36.31 0.26 µM, 04.08 0.86 12.42 0.32 08.05 0.06 26.36 0.52 against peroxidase , acetylcholinesterase (AChE) butyrylcholinesterase (BChE) respectively. Amongst, compound 5a showed excellent with 0.86, peroxidase, Finally, aforesaid taken in silico molecular modeling cytochrome c (PDB id: 2 × 08), ID: 7E3H), 4BDS).

Language: Английский

Citations

0
Design, molecular docking and biological study of novel phenoxyquinoline bearing pyrazole scaffolds as potent anticancer agents DOI

Vadlamani Nagarjuna,

Suresh Maddila, Ravikumar Kapavarapu

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 142213 - 142213

Published: March 1, 2025

Language: Английский

Citations

0
Medicinal chemistry-based perspective on thiophene and its derivatives: Exploring the structural insights to discover plausible druggable leads DOI
Shikha Thakur, Devendra Kumar, Shivani Jaiswal

et al.

RSC Medicinal Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 31, 2024

Thiophene is a privileged pharmacophore in medicinal chemistry owing to its diversified biological attributes.

Language: Английский

Citations

2
A facile and green synthesis of poly-hydroquinoline analogues in aqueous medium by CeO2-FAp@MWCNT as recyclable catalyst DOI

Varalakshmi Potala,

Kranthi Kumar Gangu,

Kommu Jayarao

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1317, P. 139119 - 139119

Published: June 24, 2024

Language: Английский

Citations

1
A rapid, efficient microwave-assisted synthesis of novel bis-pyrazole analogues using non-toxic and cost-effective catalyst under green solvent medium DOI

Komati Satish Kumar,

Alice R. Robert,

Adapaka Venkateswara Rao

et al.

Chemical Data Collections, Journal Year: 2024, Volume and Issue: unknown, P. 101165 - 101165

Published: Sept. 1, 2024

Language: Английский

Citations

0