Novel Copper(II) Coordination Compounds Containing Pyridine Derivatives of N4-Methoxyphenyl-Thiosemicarbazones with Selective Anticancer Activity DOI Creative Commons
Roman Rusnac, Olga Garbuz, Victor Kravtsov

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(24), P. 6002 - 6002

Published: Dec. 19, 2024

Ten coordination compounds, [Cu(L1)Cl] (C1), [Cu(L1)NO3] (C2), [Cu(L2)Cl] (C3), [Cu(L2)NO3] (C4), [Cu(L3)Cl] (C5), [Cu(L3)NO3] (C6), [Cu(L4)NO3] (C7), [Cu(L4)Cl] (C8), [Cu(L5)Cl] (C9), and [Cu(L5)NO3] (C10), containing pyridine derivatives of N4-methoxyphenyl-thiosemicarbazones were synthesized characterized. The molecular structure four compounds was investigated using single crystal X-ray diffraction. Spectral analysis techniques such as FT-IR, 1H NMR, 13C elemental analysis, molar conductivity used for all the compounds. tested evaluated their anticancer activity selectivity against a variety cancer cell lines, including HL-60, LNCaP, MCF-7, HepG-2, K-562, HeLa, BxPC-3, RD, MDCK normal line. Most demonstrated selective superior to doxorubicin. Notably, ligands showed high antiproliferative HL-60 cells, with IC50 values between 0.01 0.06 µM index 5000. Coordination copper(II) HL1 HL3 notably enhanced activity, lowering 0.03 µM. Additionally, antioxidant these assessed, revealing that most exhibited greater compared Trolox, some showing up 12.3 times higher. Toxicity studies on Daphnia magna indicated low toxicity ligands, generally less than doxorubicin, LC50 ranging from 13 90 µM, suggesting moderate toxicity. Conversely, complexes more toxic, 0.5

Language: Английский

Design, synthesis, in-vitro and in-silico studies of 6-bromochromone based thiosemicarbazones as α-glucosidase inhibitors DOI

Kholood A. Dahlous,

Muhammad Ajmal,

Naeem Ullah

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141374 - 141374

Published: Jan. 1, 2025

Language: Английский

Citations

2
Synthesis, spectral, antibacterial and NLO properties of organotin(IV) complexes of Thiosemicarbazones and Semicarbazones DOI
Har Lal Singh,

Jangbhadur Singh,

Sarita Khaturia

et al.

Journal of Organometallic Chemistry, Journal Year: 2024, Volume and Issue: 1015, P. 123206 - 123206

Published: May 31, 2024

Language: Английский

Citations

5
A review of recent research on the antimicrobial activities of thiosemicarbazone-based compounds DOI Creative Commons
Gürsel Korkmaz

Journal of New Results in Science, Journal Year: 2024, Volume and Issue: 13(1), P. 61 - 83

Published: April 30, 2024

Thiosemicarbazones can be synthesized by condensation of thiosemicarbazides with ketones or aldehydes and play a role as precursors in the synthesis many compounds such thiazoles. They exhibit biological activities anti-inflammatory, antitumor, antimicrobial properties. The discovery antibiotics was an important milestone treatment bacterial infections. However, resistance developed microorganisms has created need to discover new agents. thiosemicarbazone-based show significant potential. This review investigates activity results 244 Thiosemicarbazone-based over last five years. We summarized some articles on thiosemicarbazones their hybrids showing only antibacterial antifungal Web Science (WOS) between 2019 2024.

Language: Английский

Citations

4
Antifungal effects of thiosemicarbazone-chalcones on Aspergillus, Candida and Sporothrix strains DOI
William Queiroz Felippe, Igor Resendes Barbosa,

A. A. P. Oliveira

et al.

Archives of Microbiology, Journal Year: 2025, Volume and Issue: 207(1)

Published: Jan. 1, 2025

Language: Английский

Citations

0
Strategies with spectroscopic and optical insights for optoelectronic applications of novel synthesized Schiff base: impact of nitro group DOI
Anjali Jha,

B. Rajesh Kumar,

Ch. Ravi Shankar Kumar

et al.

Structural Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

Language: Английский

Citations

0
Spectroscopic, DFT, anti-bacterial, and in-silico investigations of novel semicarbazone and thiosemicarbazone synthesised from asymmetrical chalcones DOI Creative Commons

Nikita Sharma,

Har Lal Singh

Next Materials, Journal Year: 2025, Volume and Issue: 7, P. 100511 - 100511

Published: Feb. 5, 2025

Language: Английский

Citations

0
Synthesis, Characterization, and DFT Insights into Non‐linear Optical Properties of Ethoxysalicylaldehyde Thiosemicarbazone Derivatives DOI Open Access

Rifat Jawaria,

Muhammad Khalid,

Sidra Munir

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(13)

Published: March 28, 2025

Abstract In this study, a series of novel 3‐ethoxysalicylaldehyde‐based thiosemicarbazones ( 1–4 ) were synthesized via condensation reaction between 3‐ethoxysalicylaldehyde and substituted thiosemicarbazides in ethanol. The compounds 1 – 4) characterized using various spectroscopic techniques including NMR H 13 C), UV–Visible, FT‐IR spectroscopy. To explore their electronic properties, DFT TD‐DFT calculations performed, focusing on nonlinear optical (NLO) frontier molecular orbitals (FMOs), vibrational bands, UV–Vis absorption, NBO analysis. Global reactivity descriptors showed that exhibit appropriate hardness softness values, contributing to stability. analysis further revealed strong hyperconjugations significantly contributed Among the compounds, 3 exhibited narrowest band gap (4.721 eV), highest (0.211 eV⁻¹), lowest (2.360 highlighting its notable properties. A comparative study with urea indicated all possess higher values hyperpolarizability than standard urea. decreasing order observed for β total studied species is found as > 4 2 . compound value (857.582 a.u), indicating potential an NLO material. Furthermore, GRDs suggest properties particularly may contribute biological field.

Language: Английский

Citations

0
Synthesis, spectral investigation and antimicrobial assay of 2-ethoxy-6-(((3-nitrophenyl)imino)methyl)phenol and its Co(II) and Cu(II) complexes DOI

V. Gomathi,

R. Rajaram,

Kavita Devi

et al.

Published: April 4, 2025

Abstract In the present work, [Co2(EN-H)2Cl2] and [Cu2(EN-H)2Cl2] were synthesized using Schiff base, 2-ethoxy-6-(((3-nitrophenyl)imino)methyl)phenol [EN(3)], which is derived from 3-nitroaniline 3-ethoxysalicylaldehyde. The nature of bonding structural features base its complexes have been deduced molar conductance, FT-IR, electronic, 1H NMR, HRMS, fluorescence spectra. antimicrobial activities Co(II) Cu(II) investigated against Staphylococcus aureus, Escherichia coli, Aspergillus niger by agar-well diffusion method. Both exhibit substantial activities. displays significant activity compared to standard drug oxytetracycline amphotericin B, suggests it may be potential activity. efficiency order towards aureus EN(3) < [Cu2(EN-H)2Cl2]. case E. [Cu2(EN-H)2Cl2].The efficacy niger is From obtained results, arrived that proposed possess antimicrobial, as well antifungal

Language: Английский

Citations

0
rGO/CuO NC catalyzed green synthesis, DFT studies, Mulliken atomic charge analysis and anti-inflammatory activity of indole derivatives DOI
Ravina Meena, Abhinav Raj Khandelwal, Khushboo Sharma

et al.

Journal of Organometallic Chemistry, Journal Year: 2024, Volume and Issue: 1019, P. 123322 - 123322

Published: Aug. 20, 2024

Language: Английский

Citations

0
Novel Copper(II) Coordination Compounds Containing Pyridine Derivatives of N4-Methoxyphenyl-Thiosemicarbazones with Selective Anticancer Activity DOI Creative Commons
Roman Rusnac, Olga Garbuz, Victor Kravtsov

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(24), P. 6002 - 6002

Published: Dec. 19, 2024

Ten coordination compounds, [Cu(L1)Cl] (C1), [Cu(L1)NO3] (C2), [Cu(L2)Cl] (C3), [Cu(L2)NO3] (C4), [Cu(L3)Cl] (C5), [Cu(L3)NO3] (C6), [Cu(L4)NO3] (C7), [Cu(L4)Cl] (C8), [Cu(L5)Cl] (C9), and [Cu(L5)NO3] (C10), containing pyridine derivatives of N4-methoxyphenyl-thiosemicarbazones were synthesized characterized. The molecular structure four compounds was investigated using single crystal X-ray diffraction. Spectral analysis techniques such as FT-IR, 1H NMR, 13C elemental analysis, molar conductivity used for all the compounds. tested evaluated their anticancer activity selectivity against a variety cancer cell lines, including HL-60, LNCaP, MCF-7, HepG-2, K-562, HeLa, BxPC-3, RD, MDCK normal line. Most demonstrated selective superior to doxorubicin. Notably, ligands showed high antiproliferative HL-60 cells, with IC50 values between 0.01 0.06 µM index 5000. Coordination copper(II) HL1 HL3 notably enhanced activity, lowering 0.03 µM. Additionally, antioxidant these assessed, revealing that most exhibited greater compared Trolox, some showing up 12.3 times higher. Toxicity studies on Daphnia magna indicated low toxicity ligands, generally less than doxorubicin, LC50 ranging from 13 90 µM, suggesting moderate toxicity. Conversely, complexes more toxic, 0.5

Language: Английский

Citations

0