Analytical Methods,
Journal Year:
2024,
Volume and Issue:
16(25), P. 4024 - 4040
Published: Jan. 1, 2024
Environmental
pollutants
like
chlorophenol
chemicals
and
their
derivatives
are
commonplace.
These
compounds
serve
as
building
blocks
in
the
production
of
medicines,
biocides,
dyes,
agricultural
chemicals.
Chlorophenols
enter
environment
through
several
different
pathways,
including
breakdown
complex
chlorinated
hydrocarbons,
industrial
waste,
herbicides,
insecticides.
destroyed
thermally
chemically,
creating
dangerous
that
pose
a
threat
to
public
health.
Water
particular
is
affected,
thorough
monitoring
required
find
this
source
pollution
because
it
can
major
hazard
both
human
environmental
For
detection
chlorophenols,
molecularly
imprinted
polymers
(MIPs)
have
been
incorporated
into
variety
electrochemical
sensing
systems
assay
formats.
Due
long-term
chemical
physical
stability
well
simple
affordable
synthesis
process,
MIPs
become
intriguing
synthetic
alternatives
over
past
few
decades.
In
review,
we
concentrate
on
commercial
potential
MIP
technology.
Additionally,
want
outline
most
recent
advancements
incorporation
sensors
with
high
for
detecting
chlorophenols.
Chemistry & Biodiversity,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 16, 2024
Abstract
Acetaminophen,
a
centrally‐acting
old
analgesic
drug,
is
weak
inhibitor
of
cyclooxygenase
(COX)
isoforms
with
some
selectivity
toward
COX‐2.
This
compound
was
used
in
this
work
as
precursor
to
create
nine
acetaminophen
based
coumarins
(ACFs).
To
satisfy
the
aim
work,
which
states
synthesis
acetaminophen‐based
selective
COX‐2
inhibitors,
ACFs
were
subjected
two
types
investigation:
vitro
and
silico
.
Given
former
type,
capacity
block
COX‐1
investigated
lab
settings.
On
other
hand,
investigation
included
docking
chemical
structures
into
active
sites
these
enzymes,
predicting
their
anticipated
toxicities,
determining
ADME
characteristics.
The
results
study
revealed
that
synthesized
demonstrated
good‐to‐excellent
inhibitory
properties
against
enzymes
under
study.
Also,
exhibited
high
level
selectivity,
improved
aromatic
substitute
for
withdrawing
electrons
enhanced.
Results
comparable
case
investigations
indicated
are
safer
than
precursor,
acetaminophen,
potential
consider
oral‐administrated
candidates.
Analytical Methods,
Journal Year:
2024,
Volume and Issue:
16(25), P. 4024 - 4040
Published: Jan. 1, 2024
Environmental
pollutants
like
chlorophenol
chemicals
and
their
derivatives
are
commonplace.
These
compounds
serve
as
building
blocks
in
the
production
of
medicines,
biocides,
dyes,
agricultural
chemicals.
Chlorophenols
enter
environment
through
several
different
pathways,
including
breakdown
complex
chlorinated
hydrocarbons,
industrial
waste,
herbicides,
insecticides.
destroyed
thermally
chemically,
creating
dangerous
that
pose
a
threat
to
public
health.
Water
particular
is
affected,
thorough
monitoring
required
find
this
source
pollution
because
it
can
major
hazard
both
human
environmental
For
detection
chlorophenols,
molecularly
imprinted
polymers
(MIPs)
have
been
incorporated
into
variety
electrochemical
sensing
systems
assay
formats.
Due
long-term
chemical
physical
stability
well
simple
affordable
synthesis
process,
MIPs
become
intriguing
synthetic
alternatives
over
past
few
decades.
In
review,
we
concentrate
on
commercial
potential
MIP
technology.
Additionally,
want
outline
most
recent
advancements
incorporation
sensors
with
high
for
detecting
chlorophenols.
