New benzimidazole–indole–amide derivatives as potent α‐glucosidase and acetylcholinesterase inhibitors DOI
Narges Naimi, Somaye Karimian,

Navid Dastyafteh

et al.

Archiv der Pharmazie, Journal Year: 2024, Volume and Issue: 358(1)

Published: Dec. 25, 2024

Abstract New derivatives 6a–m with benzimidazole–indole–amide scaffold were developed, synthesized, and assessed for potential inhibitory effects on α‐glucosidase acetylcholinesterase (AChE). These compounds synthesized by various amine derivatives. With the exception of two compounds, activities title more than that positive control acarbose. Moreover, anti‐AChE activity these one compound, was better tacrine (standard inhibitor). The most potent compound against 3‐methylphenyl derivative 6i AChE 3,4‐dimethoxyphenethyl 6m . All placed in active sites silico docking method obtained binding energies approximately agreement vitro observed data. Interaction modes demonstrated interacted important residues their target enzymes. Molecular dynamics simulation conducted specifically complex to obtain deeper insights into behavior this molecule. Furthermore, pharmacokinetic toxicity studies predicted have good profiles terms oral absorption toxicity.

Language: Английский

Breaking Boundaries in Diabetic Nephropathy Treatment: Design and Synthesis of Novel Steroidal SGLT2 Inhibitors DOI
Geetmani Singh Nongthombam, Semim Akhtar Ahmed,

Kangkon Saikia

et al.

RSC Medicinal Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Virtual screening and synthetic modification of natural product-derived steroidal precursors as potential SGLT2 inhibitors for the treatment diabetic nephropathy.

Language: Английский

Citations

0
New benzimidazole–indole–amide derivatives as potent α‐glucosidase and acetylcholinesterase inhibitors DOI
Narges Naimi, Somaye Karimian,

Navid Dastyafteh

et al.

Archiv der Pharmazie, Journal Year: 2024, Volume and Issue: 358(1)

Published: Dec. 25, 2024

Abstract New derivatives 6a–m with benzimidazole–indole–amide scaffold were developed, synthesized, and assessed for potential inhibitory effects on α‐glucosidase acetylcholinesterase (AChE). These compounds synthesized by various amine derivatives. With the exception of two compounds, activities title more than that positive control acarbose. Moreover, anti‐AChE activity these one compound, was better tacrine (standard inhibitor). The most potent compound against 3‐methylphenyl derivative 6i AChE 3,4‐dimethoxyphenethyl 6m . All placed in active sites silico docking method obtained binding energies approximately agreement vitro observed data. Interaction modes demonstrated interacted important residues their target enzymes. Molecular dynamics simulation conducted specifically complex to obtain deeper insights into behavior this molecule. Furthermore, pharmacokinetic toxicity studies predicted have good profiles terms oral absorption toxicity.

Language: Английский

Citations

0