New 1,2,3-triazole-quinazolinone skeleton as potential cholinesterase and α-amylase inhibitors: In vitro and in silico studies

Journal of Molecular Liquids, Journal Year: 2025, Volume and Issue: 424, P. 126986 - 126986

Published: Jan. 22, 2025

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Key molecular scaffolds in the development of clinically viable α-amylase inhibitors

Future Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 17(3), P. 347 - 362

Published: Jan. 21, 2025

The escalating cases of type II diabetes combined with adverse side effects current antidiabetic drugs spurred the advancement innovative approaches for management postprandial glucose levels. α-Amylase is an endoamylase responsible breakdown internal α-1,4-glycosidic linkages in dietary starch, producing oligosaccharides. Subsequently, α-glucosidase degraded these oligosaccharides to monosaccharides, which are absorbed into bloodstream and become available body. inhibitors α-amylase reduced digestibility carbohydrates accompanied by delayed absorption, leading decreased blood levels after meals thus, inhibition enzyme seems be a crucial strategy improving overall glycemic control diabetic patients. present review article emphasizes therapeutic promise recently discovered potential inhibitors, highlighting their vitro, silico vivo profiles. Ultimately, we addressed contemporary challenges routes ahead search safe reliable clinical use, summarizing most recent research field.

Language: Английский

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Rational design of new quinoline-benzimidazole scaffold bearing piperazine acetamide derivatives as antidiabetic agents

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 153, P. 107908 - 107908

Published: Oct. 30, 2024

Language: Английский

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Synthesis, Characterization, Enzyme Inhibition and Molecular Docking Studies of Benzothiazole Derivatives Bearing Alkyl Phenyl Ether Fragments

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1319, P. 139504 - 139504

Published: July 30, 2024

Language: Английский

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Synthesis and Evaluation of Some Novel 1,3-Dimethylbarbituric Acid Derivatives as Potent Anti-Urease Agents: Comprehension through In Vitro, Molecular Docking, and DFT Investigations

Russian Journal of Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 50(5), P. 1609 - 1626

Published: Oct. 1, 2024

Language: Английский

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Synthesis of newly designed hydrazones, in vitro and in silico studies, and Structure-Activity Relationship

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1322, P. 140417 - 140417

Published: Oct. 18, 2024

Language: Английский

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Exploring 1,3,4-Oxadiazole Derivatives of 3,4-Dihydroxyphenylacetic Acid as Potent α-Glucosidase Inhibitors: Synthesis, Structure-Activity Relationship, Molecular Docking, and DFT Studies

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 141211 - 141211

Published: Dec. 1, 2024

Language: Английский

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Synthesis, Urease Inhibitory Activity, Molecular Docking, Dynamics, MMGBSA and DFT Studies of Schiff Bases Bearing Benzimidazole Scaffold

Chemistry & Biodiversity, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 12, 2024

In this study, eleven hydrazone-Schiff bases bearing benzimidazole moiety were synthesized successfully via three step reactions and structures of these products deduced by HR-ESI-MS,

Language: Английский

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Discovery and synthesis of novel phenoxyacetate ester Schiff base α-glucosidase inhibitors

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 154, P. 107952 - 107952

Published: Nov. 15, 2024

Language: Английский

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