Novel europium(III), terbium(III), and gadolinium(III) Schiff base complexes: Synthesis, structural, photoluminescence, antimicrobial, antioxidant, and molecular docking studies DOI
Hatice Gamze Soğukömeroğulları, Eyüp Başaran, Remziye Aysun Kepekçi

et al.

Polyhedron, Journal Year: 2024, Volume and Issue: unknown, P. 117275 - 117275

Published: Oct. 1, 2024

Language: Английский

Comprehensive Study on Synthesis, Quantum Chemical Calculations, Molecular Modeling Studies, and Cytotoxic Activities of Metal(II) Schiff Base Complexes DOI Creative Commons
Hatice Gamze Soğukömeroğulları, Bülent Dede, Dicle Sahin

et al.

Applied Organometallic Chemistry, Journal Year: 2025, Volume and Issue: 39(3)

Published: Feb. 5, 2025

ABSTRACT In this study, mononuclear Ni(II), Cu(II), Zn(II), and Pd(II) complexes of a diimine molecule (H 2 L) were synthesized, their structures elucidated by NMR, FT‐IR, UV–Vis, ICP‐OES, molar conductivity, magnetic susceptibility, elemental analysis techniques. Stoichiometric spectroscopic data revealed that the have metal:ligand ratio 1:1 Schiff base coordinates with metal(II) ion via nitrogen atoms two imine groups oxygen anions phenolate moieties square planar geometry. The cytotoxic activity properties ligand its metal screened in distinct cancer cell lines: lung (A549) colon (DLD‐1). optimized molecular geometries, electrostatic potential diagrams, total density states plots, frontier orbitals H L all at ground level calculated using functional theory. LANL2DZ basis set containing effective core potentials for transition metals was used quantum chemical calculations. calculations supported geometry ions complexes. molecules to inhibit MLK4 kinase domain (PDB ID: 4UYA) involved progression examined docking study best inhibition belonged binding energy −10.8 kcal/mol. stability L–4UYA complex physiological media also confirmed dynamics simulation 100 ns.

Language: Английский

Citations

1
Transition metal complexes of sulfonamide-based Schiff base ligand: Synthesis, Characterization, A Biological assessment, DFT, and ADME studies DOI
Ahmet Oral Sarıoğlu, Burçin Türkmenoğlu, Demet Taşdemir Kahraman

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 140907 - 140907

Published: Nov. 1, 2024

Language: Английский

Citations

4
Thiophene-based Hydrazones and Their Metal Complexes: Synthesis, Structure Affirmation, Antioxidant and Cytotoxic Activity, Photoluminescence, Molecular Docking, and ADMET Studies DOI
Ahmet Oral Sarıoğlu, Zafer Bulut, Burçin Türkmenoğlu

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141716 - 141716

Published: Feb. 1, 2025

Language: Английский

Citations

0
Synthesis and Characterization of Novel Hydrazone Complexes: Exploring DNA/BSA Binding and Antimicrobial Potential DOI Creative Commons
Jeniffer Meyer Moreira, Sara Vieira, Gil Correia

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: 10(7), P. 7428 - 7440

Published: Feb. 13, 2025

Research involving coordination chemistry with Schiff base hydrazones finds applications in various areas, particularly bioinorganic and biomedicine. This work aims to contribute this field by employing the ligand (E)-2-((2-(benzothiazol-2-yl)hydrazone)methyl)phenol (H2L), synthesized via a condensation reaction salicylic aldehyde. The was isolated, characterized, subsequently complexed nickel(II) chloride copper(II) nitrate, yielding three new crystalline complexes: [Ni(HL)2] (1), [Ni2(L)2(Py)2(EtOH)]·DMF·0.5H2O (2), [Cu3(L#)2(DMF)2] (3) (where Py = pyridine). metal complexes were structurally characterized using IR, UV–vis, TGA-DSC, SCXRD techniques. These analyses confirmed of center nitrogen oxygen donor atoms, establishing formation mono-, bi-, trinuclear complexes, respectively. DNA interaction studies performed through spectroscopic titration viscosity measurements, indicating that interact an intercalative mode, order being 3 > 2> 1. Partition coefficient analysis revealed 1 have greater tendency partition into organic phase, suggesting their potential cross lipid membranes, while complex 2 are more hydrophilic. Fluorescence-based BSA binding demonstrated interactions between biomolecule, following same as observed interaction. Biological tests showed lacked antimicrobial antiyeast activity, biologically active. Notably, copper displayed strongest antibacterial effect, likely due copper's essential biological role.

Language: Английский

Citations

0
Novel transition metal (II) complexes of hydrazones as potential antitumor agents: Synthesis, characterization, DFT computations, cytotoxic activities, molecular docking and simulation studies DOI
Hatice Gamze Soğukömeroğulları, Eyüp Başaran, Reşit Çakmak

et al.

Inorganica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 122634 - 122634

Published: March 1, 2025

Language: Английский

Citations

0
Copper(II), cobalt(II), nickel(II), and iron(II) mixed complexes formed by Schiff base and 1,10-phenanthroline as secondary chelates: Preparation, characterization, antimicrobial, antioxidant, and molecular docking studies DOI
Hatice Gamze Soğukömeroğulları, Ahmet Oral Sarıoğlu, Remziye Aysun Kepekçi

et al.

Inorganica Chimica Acta, Journal Year: 2025, Volume and Issue: unknown, P. 122692 - 122692

Published: April 1, 2025

Language: Английский

Citations

0
Novel europium(III), terbium(III), and gadolinium(III) Schiff base complexes: Synthesis, structural, photoluminescence, antimicrobial, antioxidant, and molecular docking studies DOI
Hatice Gamze Soğukömeroğulları, Eyüp Başaran, Remziye Aysun Kepekçi

et al.

Polyhedron, Journal Year: 2024, Volume and Issue: unknown, P. 117275 - 117275

Published: Oct. 1, 2024

Language: Английский

Citations

3