New Metal Complexes Incorporating Schiff Base Ligand Based on Pyridine Moiety: Synthesis, Spectral Characterization, DFT, Biological Evaluation, and Molecular Docking DOI Open Access
Nesma Salah, Omima M.I. Adly, Magdy A. Ibrahim

et al.

Applied Organometallic Chemistry, Journal Year: 2024, Volume and Issue: 39(1)

Published: Oct. 9, 2024

ABSTRACT A new Schiff base ligand, HNMPC , was prepared and reacted with some metal ions, including Cu(II), Ni(II), Co(II), Mn(II), VO(IV). The infrared, electronic, mass, electron spin resonance, nuclear magnetic thermal elemental analysis, molar conductance, susceptibility measurements were used to characterize the complexes. ligand acts as a monoanionic tridentate ONO donor in all complexes, coordinating sites are C=O pyridone C=N, phenolate anion. All complexes exhibit octahedral configurations, results showed that ion:ligand ratio 1:2. molecular structural parameters of its determined based on DFT level implemented Gaussian 09 program B3LYP/GENECP method at 6‐311G(d,p) basis set for C, H, N, O atoms SDD (Stuttgart/Dresden) atoms. theoretical data correlated experimental results. Gram‐positive bacteria, Gram‐negative yeast, fungi test current compounds' antimicrobial activity. Investigating antitumor activity against HepG2 cell lines encouraging IC 50 values par those cisplatin . In order determine affinity binding pattern synthesized compounds toward VEGFR‐2 active site, docking studies conducted, data. Based obtained results, future work aimed synthesize category bases their derived from aminopyridine derivative diverse aldehydes ketones.

Language: Английский

Self-assembled complexes: From molecules to bioderived materials for sustainable sensing technologie DOI
Jay Singh, Shyam S. Pandey,

Arunadevi Natarajan

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141414 - 141414

Published: Jan. 1, 2025

Language: Английский

Citations

0
New Metal Complexes Incorporating Schiff Base Ligand Based on Pyridine Moiety: Synthesis, Spectral Characterization, DFT, Biological Evaluation, and Molecular Docking DOI Open Access
Nesma Salah, Omima M.I. Adly, Magdy A. Ibrahim

et al.

Applied Organometallic Chemistry, Journal Year: 2024, Volume and Issue: 39(1)

Published: Oct. 9, 2024

ABSTRACT A new Schiff base ligand, HNMPC , was prepared and reacted with some metal ions, including Cu(II), Ni(II), Co(II), Mn(II), VO(IV). The infrared, electronic, mass, electron spin resonance, nuclear magnetic thermal elemental analysis, molar conductance, susceptibility measurements were used to characterize the complexes. ligand acts as a monoanionic tridentate ONO donor in all complexes, coordinating sites are C=O pyridone C=N, phenolate anion. All complexes exhibit octahedral configurations, results showed that ion:ligand ratio 1:2. molecular structural parameters of its determined based on DFT level implemented Gaussian 09 program B3LYP/GENECP method at 6‐311G(d,p) basis set for C, H, N, O atoms SDD (Stuttgart/Dresden) atoms. theoretical data correlated experimental results. Gram‐positive bacteria, Gram‐negative yeast, fungi test current compounds' antimicrobial activity. Investigating antitumor activity against HepG2 cell lines encouraging IC 50 values par those cisplatin . In order determine affinity binding pattern synthesized compounds toward VEGFR‐2 active site, docking studies conducted, data. Based obtained results, future work aimed synthesize category bases their derived from aminopyridine derivative diverse aldehydes ketones.

Language: Английский

Citations

3