
Chimica Techno Acta, Journal Year: 2024, Volume and Issue: 11(4)
Published: Nov. 27, 2024
Selective sensors for the detection and quantification of Cu(II) ions are actively used to investigate in vivo conditions Wilsons Menkes diseases at cellular level. Such must have a high specificity this cation as well low toxicity. A synthetic approach preparation selective cations based on p-tert-butylthiacalix[4]arenes modified with 3,5-dimethylpyrazole moieties cone, partial cone 1,3-alternate stereoisomeric forms was developed. The obtained compounds were characterized by single-crystal XRD, NMR IR spectroscopy, MALDI MS, elemental analysis. All synthesized thiacalixarene formed complexes binding constants range logK = 4.44–4.63 1:1 stoichiometry. structure studied spectroscopy DFT methods. results can be develop sensors.
Language: Английский