Synthesis and selective Cu(II) complexation of lower rim substituted thiacalixarenes containing pyrazole fragments DOI Creative Commons
Valeriy Kalinin,

Ekaterina Rasperetikhina,

Mikhail S. Bukharov

et al.

Chimica Techno Acta, Journal Year: 2024, Volume and Issue: 11(4)

Published: Nov. 27, 2024

Selective sensors for the detection and quantification of Cu(II) ions are actively used to investigate in vivo conditions Wilsons Menkes diseases at cellular level. Such must have a high specificity this cation as well low toxicity. A synthetic approach preparation selective cations based on p-tert-butylthiacalix[4]arenes modified with 3,5-dimethylpyrazole moieties cone, partial cone 1,3-alternate stereoisomeric forms was developed. The obtained compounds were characterized by single-crystal XRD, NMR IR spectroscopy, MALDI MS, elemental analysis. All synthesized thiacalixarene formed complexes binding constants range logK = 4.44–4.63 1:1 stoichiometry. structure studied spectroscopy DFT methods. results can be develop sensors.

Language: Английский

Synthesis and selective Cu(II) complexation of lower rim substituted thiacalixarenes containing pyrazole fragments DOI Creative Commons
Valeriy Kalinin,

Ekaterina Rasperetikhina,

Mikhail S. Bukharov

et al.

Chimica Techno Acta, Journal Year: 2024, Volume and Issue: 11(4)

Published: Nov. 27, 2024

Selective sensors for the detection and quantification of Cu(II) ions are actively used to investigate in vivo conditions Wilsons Menkes diseases at cellular level. Such must have a high specificity this cation as well low toxicity. A synthetic approach preparation selective cations based on p-tert-butylthiacalix[4]arenes modified with 3,5-dimethylpyrazole moieties cone, partial cone 1,3-alternate stereoisomeric forms was developed. The obtained compounds were characterized by single-crystal XRD, NMR IR spectroscopy, MALDI MS, elemental analysis. All synthesized thiacalixarene formed complexes binding constants range logK = 4.44–4.63 1:1 stoichiometry. structure studied spectroscopy DFT methods. results can be develop sensors.

Language: Английский

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