Efficient Synthesis of Dihydropyrimidinones Using Advanced Ni (II)‐Doped Zn‐BDC Microcrystals: A Breakthrough in Catalytic Performance, Reusability, and Structural Integrity

Applied Organometallic Chemistry, Journal Year: 2025, Volume and Issue: 39(3)

Published: Jan. 30, 2025

ABSTRACT Nickel (II) ions (Ni (II)) doped into the zinc‐based metal–organic framework Zn‐BDC have shown exceptional catalytic activity as heterogeneous catalysts for three‐component Biginelli condensation reaction, delivering yields ranging from 62% to 96% with excellent selectivity under diverse reaction conditions. The Ni doping was achieved through a facile solvothermal synthesis, producing Ni(x)‐Zn‐BDC catalysts, where x represents weight percentage of relative Zn (e.g., Ni[10]‐Zn‐BDC). Comprehensive characterization synthesized conducted using advanced spectroscopic and analytical techniques, confirming successful incorporation without compromising its structural integrity. Ni(10)‐Zn‐BDC catalyst, in particular, exhibited remarkable efficiency facilitating mild Furthermore, catalyst demonstrated recyclability stability, maintaining consistent performance over multiple cycles. These findings highlight promising sustainable material synthesis dihydropyrimidinones, underscoring potential green efficient processes.

Language: Английский

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New Azo‐Azomethine Compounds: Comprehensive Evaluation of In Silico Biological Activities, ADMEt Profiling, and In Vitro Antioxidant Properties

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(12)

Published: March 1, 2025

Abstract The discovery of novel azo‐azomethine compounds and the exploration their biological activities are critical for expanding pool potential drug candidates. In this study, four new fluorine‐substituted azo‐azomethines ( 4a–d ), containing groups such as ─CF₃ ─OCF₃, were successfully synthesized in high yields. Their vitro antioxidant evaluated using CUPRAC method, results indicate that all demonstrated higher TEAC values compared to standard Trolox. Notably, compound 4d exhibited highest value 2.22. A comparative analysis indicated activity was influenced not only by presence fluorine‐based substituents but also number hydroxyl (─OH) structures. ADMEt properties assessed, revealing adhered Lipinski's rule five. Additionally, molecular docking studies performed examine various activities, targeting specific proteins involved disease mechanisms. findings revealed that; Among compounds, 4b ‐2XIR complex displayed score −11.0 kcal/mol, indicating strong binding affinity. These suggest have significant candidates treatment specified diseases.

Language: Английский

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Highly Efficient Blue LED Light Induced Oxidation of Amines to Imines Catalyzed by Green synthesized SnO2@RVT Nanocomposite

Surfaces and Interfaces, Journal Year: 2025, Volume and Issue: unknown, P. 106358 - 106358

Published: March 1, 2025

Language: Английский

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Chalcone derivatives containing 1,2,4-triazole and pyridine moiety: design, synthesis, and antiviral activity

Molecular Diversity, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 2, 2024

Language: Английский

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