Advances in Organic Fluorescent and Colorimetric Probes for The Detection of Cu ²⁺ and Their Applications in Cancer Cell Imaging (2020–2024)

Critical Reviews in Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 27

Published: Jan. 21, 2025

Organic fluorescence and colorimetric probes have emerged as vital tools for detecting metal ions, due to their high sensitivity, selectivity, rapid response times. Copper, an essential trace element, plays a critical role in biological systems, yet its imbalance can lead severe disorders such neurodegenerative diseases, cancer, Wilson's disease. Over the past few years, advancements probe design unlocked innovative avenues not only Cu2+ environmental samples but also visualizing distribution through imaging. These offering robust performance under diverse conditions. Fluorescence imaging using these pivotal cancer diagnosis, prognosis, treatment monitoring by real-time visualization of tumor morphology biomolecular interactions at cellular tissue levels. This review aims explore diversity organic developed detection Cu2+, with particular focus on applications from 2020 2024. The discussion highlights use various cells SiHa, HCT 116, GES-1, RAW 264.7, HepG2, HeLa, MCF-7 DrG cell lines, tissues, small living organisms. By targeting cancer-specific pathways copper-related physiological changes, significantly advanced fields diagnostics therapeutics. comprehensive analysis emphasizes potential powerful tool elucidating roles health disease, paving way future advances biomedical research.

Language: Английский

Two Zn-based metal-organic frameworks constructed with the mixed ligands for fluorescence detection of Cu2+ and Co2+

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141608 - 141608

Published: Jan. 1, 2025

Language: Английский