Innovative Synthesis and Application of Bridged Nitrogen Heterocycles: From Diazotized Sulfur Dyes to Enhanced Polyester Fabrics

Chemistry Africa, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 8, 2025

Language: Английский

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Small-Molecule Tyrosinase Inhibitors for Treatment of Hyperpigmentation

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 788 - 788

Published: Feb. 8, 2025

Increasing attention is being focused on skin health currently, especially the excessive deposition of melanin in skin. Tyrosinase, rate-limiting enzyme biosynthesis, a crucial synthesis. However, existing tyrosinase inhibitors pose some degree toxicity to humans. Therefore, development more efficient and low-toxicity urgently needed. This review briefly depicts biosynthesis process crystal structure catalytic mechanism tyrosinase. The latest research progress regarding small-molecule also reviewed. Moreover, structure-function relationships are analyzed summarized. expected provide new scientific insights enable researchers explore safer potent inhibitors.

Language: Английский

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TiO2/RuO2/CuO catalysed green synthesis of novel spiropyrrolizidines and their anticancer activity: Synthesis, single crystal X-ray diffraction, DFT, Hirshfeld and molecular docking studies.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141955 - 141955

Published: March 1, 2025

Language: Английский

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Synthesis and Computational Evaluation of Azaheterocyclic Inhibitors Targeting TGFβRI: Integrating TD-DFT, Physicochemical Profiling, Molecular Docking, and Molecular Dynamics

Arabian Journal for Science and Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Language: Английский

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