Design, synthesis, and antitubercular evaluation of piperazinyl-pyrazolyl-2- hydrazinyl thiazole derivatives: Experimental, DFT and molecular docking insights

Journal of Sulfur Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 26

Published: Feb. 10, 2025

Language: Английский

Synthesis and Biological Evaluation of Bile Acid–Triclosan Conjugates: A Study on Antibacterial, Antibiofilm, and Molecular Docking

Bioconjugate Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

This work describes the synthesis, characterization, and antibacterial properties of four bile acid–triclosan conjugates. The in vitro activity synthetic conjugates was investigated against a panel Gram-positive Gram-negative bacteria. Conjugates 3 4 show high Escherichia coli (ATCC25922), with IC50 values 2.94 ± 0.7 1.51 0.05 μM, respectively. Conjugate demonstrated 9 times triclosan (6.77 μM) 18 potency kanamycin, well-known antibiotic. Compound showed higher potential all evaluated strains, including Bacillus megaterium (IC50: 3.05 0.02), amyloquefaciens 8.79 0.01), Serratia marcescens 6.77 0.4), E. μM). These findings indicate that it has broad-spectrum activity. Bile prevent biofilms by up to 99% at low doses (conjugates 4; 4.16 0.8 μM), compared triclosan. 5 most potent B. (IC50 = 5.23 0.2 while conjugate effective biofilm formation. inhibit formation limiting extracellular polymeric substance generation. study revealed were more than parent molecule inhibiting bacterial growth both

Language: Английский

Novel imidazoles from guanylhydrazone: Synthesis, computational, and molecular docking studies as α-amylase inhibitors for type 2 diabetes management

Results in Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 102313 - 102313

Published: May 1, 2025

Language: Английский