Therapeutic Potential of Nitrogen‐Substituted Oleanolic Acid Derivatives in Neuroinflammatory and Cytokine Pathways: Insights From Cell‐Based and Computational Models DOI
Gurbet Çelik Turgut,

Nicole Pepe,

Yağmur Ceylan Ekiz

et al.

Chemistry & Biodiversity, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

ABSTRACT This study was conducted to investigate the mechanism of potential and anti‐inflammatory properties nitrogen‐substituted oleanolic acid derivatives that can be used treat neuroinflammatory diseases. Nitrogen‐containing have been evaluated for their anti‐neuroinflammatory effects in vitro neuronal monocytic cell lines at nontoxic doses, production cytokines (TNF‐α, IL‐6 IL‐17), inflammatory enzyme induced nitric oxide synthase (iNOS) NF‐κB signalling under LPS‐stimulated conditions, expression genes associated with Alzheimer's disease assessed. In addition, molecular docking dynamics simulation assessments are silico. Key protein markers neurodegenerative diseases, especially neuroinflammation, TAU levels, microglial activation, as well ionised calcium‐binding adaptor protein‐1 (IBA1) were significantly reduced addition derivatives. LPS‐induced luciferase reporter activity iNOS inhibited, approaching levels uninduced controls. The mRNA proinflammatory critical such TNF‐α, NF‐κB, IL‐17, twofold sevenfold. Furthermore, MD analyses revealed interactions TNF‐α proteins. These findings underscore derivatives, particularly compound 16 , candidates further development therapeutic agents diseases chronic inflammation.

Language: Английский

Synthesis, biological evaluation, and in silico studies of phenyl naphthalene-2-sulfonate derived thiosemicarbazones as potential carbonic anhydrase inhibitors DOI

Javeria Eshal,

Hafiza Zara Tariq, Jing Li

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 155, P. 108118 - 108118

Published: Jan. 4, 2025

Language: Английский

Citations

2
Inhibition Effects of Some Phenolic Anthraquinone Derivatives on Lactoperoxidase Activity: A Detailed in Vitro and in Silico investigation DOI Creative Commons
Işıl Nihan Korkmaz, Halil Şenol, Ramazan Kalın

et al.

Food Biophysics, Journal Year: 2025, Volume and Issue: 20(2)

Published: April 11, 2025

Language: Английский

Citations

0
Therapeutic Potential of Nitrogen‐Substituted Oleanolic Acid Derivatives in Neuroinflammatory and Cytokine Pathways: Insights From Cell‐Based and Computational Models DOI
Gurbet Çelik Turgut,

Nicole Pepe,

Yağmur Ceylan Ekiz

et al.

Chemistry & Biodiversity, Journal Year: 2025, Volume and Issue: unknown

Published: April 22, 2025

ABSTRACT This study was conducted to investigate the mechanism of potential and anti‐inflammatory properties nitrogen‐substituted oleanolic acid derivatives that can be used treat neuroinflammatory diseases. Nitrogen‐containing have been evaluated for their anti‐neuroinflammatory effects in vitro neuronal monocytic cell lines at nontoxic doses, production cytokines (TNF‐α, IL‐6 IL‐17), inflammatory enzyme induced nitric oxide synthase (iNOS) NF‐κB signalling under LPS‐stimulated conditions, expression genes associated with Alzheimer's disease assessed. In addition, molecular docking dynamics simulation assessments are silico. Key protein markers neurodegenerative diseases, especially neuroinflammation, TAU levels, microglial activation, as well ionised calcium‐binding adaptor protein‐1 (IBA1) were significantly reduced addition derivatives. LPS‐induced luciferase reporter activity iNOS inhibited, approaching levels uninduced controls. The mRNA proinflammatory critical such TNF‐α, NF‐κB, IL‐17, twofold sevenfold. Furthermore, MD analyses revealed interactions TNF‐α proteins. These findings underscore derivatives, particularly compound 16 , candidates further development therapeutic agents diseases chronic inflammation.

Language: Английский

Citations

0