Discovery of immunosuppressive secondary metabolites from Hypericum patulum DOI
Fei Song, Jie Li,

Binbin Song

et al.

Journal of Asian Natural Products Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 7

Published: March 27, 2025

The chemical study of Hypericum patulum provided a new degraded lupane-type triterpenoid, patutriter A (1), and seven known compounds (2-8). Their structures were identified by spectroscopic techniques single crystal diffraction experiment. Structurally, (1) was lupane with 28-nor-skeleton. More importantly, 3-5 exhibited moderate immunosuppressive effects that inhibit the anti-CD3/anti-CD28 monoclonal antibodies (mAbs) concanavalin (ConA) stimulated murine splenocytes proliferation, IC50 values from (15.25 ± 1.78) μM to (22.58 3.47) μM, disclosing those might serve as potential lead in development immunosuppressants.

Language: Английский

Discovery of immunosuppressive secondary metabolites from Hypericum patulum DOI
Fei Song, Jie Li,

Binbin Song

et al.

Journal of Asian Natural Products Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 7

Published: March 27, 2025

The chemical study of Hypericum patulum provided a new degraded lupane-type triterpenoid, patutriter A (1), and seven known compounds (2-8). Their structures were identified by spectroscopic techniques single crystal diffraction experiment. Structurally, (1) was lupane with 28-nor-skeleton. More importantly, 3-5 exhibited moderate immunosuppressive effects that inhibit the anti-CD3/anti-CD28 monoclonal antibodies (mAbs) concanavalin (ConA) stimulated murine splenocytes proliferation, IC50 values from (15.25 ± 1.78) μM to (22.58 3.47) μM, disclosing those might serve as potential lead in development immunosuppressants.

Language: Английский

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