
Bioinorganic Chemistry and Applications, Journal Year: 2025, Volume and Issue: 2025(1)
Published: Jan. 1, 2025
To treat urinary tract infections (UTIs), biosynthesized silver and yttrium‐doped nanoparticles (AgNPs Y‐AgNPs) were synthesized from pine needle leaf extract (PNLE). The crystalline nature of the NPs was demonstrated by X‐ray diffraction. Transmission scanning electron microscopy showed that AgNPs Y‐AgNPs are dispersed spherical, with average particle sizes 18.43 26.58 nm, respectively. chemical composition oxidation states revealed photoelectron spectroscopy, while elemental compositions explored energy‐dispersive analysis. functional groups absorbance peaks Fourier transform infrared spectroscopy ultraviolet‐visible possessed luminescent behavior based on photoluminescence studies ferromagnetic according to vibrating sample magnetometer In addition, antibacterial activity against six uropathogenic bacteria assessed performing microdilution assays determine minimum inhibitory concentration (MIC) bactericidal (MBC) which ranged between 0.0625 2 mg/mL, agar well diffusion assay zones inhibition 8–17 mm, time‐kill test detecting after 3 h, antibiofilm screening at concentrations ranging 1 mg/mL. antioxidant determined 1,1, diphenyl 1‐2 picrylhydrazyl (DPPH) radical scavenging assay, a significant (14.2%–55.6%). Docking can inhibit vital enzymes DNA gyrase, penicillin‐binding proteins, carbapenemase, LasR‐binding protein, dihydropteroate synthase. These results highlight use as alternative approaches in battle antibiotic‐resistant UTIs. research illustrates increased bioactivity compared conventional AgNPs. It paves way for novel nanomaterials antimicrobial medicine.
Language: Английский