3,5-Disubstituted pyrazoline as a promising core for anticancer agents: mechanisms of action and therapeutic potentials DOI

Basma S. Gabr,

Abdelrahman R. Shalabi,

Mona F. Said

et al.

Future Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 21

Published: March 13, 2025

The rapidly growing interest in the literature about anticancer activity of 3,5-disubstituted pyrazolines and their promising therapeutic potentials/pharmacological properties, supported by number pyrazoline derivatives currently clinical use or trials, encouraged us to review vitro antiproliferative effects biochemical investigations probable mechanisms action. Nevertheless, many reported pyrazoline-bearing compounds have without an explored mode action, which opens new research avenues examine profiles further. Therefore, is a core that can be used design with based on structure-activity relationship summarized this obtain higher potency selectivity.

Language: Английский

3,5-Disubstituted pyrazoline as a promising core for anticancer agents: mechanisms of action and therapeutic potentials DOI

Basma S. Gabr,

Abdelrahman R. Shalabi,

Mona F. Said

et al.

Future Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 21

Published: March 13, 2025

The rapidly growing interest in the literature about anticancer activity of 3,5-disubstituted pyrazolines and their promising therapeutic potentials/pharmacological properties, supported by number pyrazoline derivatives currently clinical use or trials, encouraged us to review vitro antiproliferative effects biochemical investigations probable mechanisms action. Nevertheless, many reported pyrazoline-bearing compounds have without an explored mode action, which opens new research avenues examine profiles further. Therefore, is a core that can be used design with based on structure-activity relationship summarized this obtain higher potency selectivity.

Language: Английский

Citations

0