Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown

Published: May 3, 2025

Nanomedicine has significantly advanced the treatment of various cancer phenotypes, addressing numerous challenges associated with conventional therapies. Researchers have extensively investigated physicochemical properties nanocarriers, such as charge, morphology, and surface chemistry, to optimize drug delivery systems. In context transformable nanomedicine, these are particularly critical for overcoming existing limitations, including suboptimal blood circulation times, sequestration by reticuloendothelial system mononuclear phagocyte system, inefficient targeting tumor microenvironment (TME). Alterations in nanocarrier geometry, hydrophilicity shown potential mitigating barriers, offering improved therapeutic outcomes enhanced biomedical applications. This review explores controlled modulation anticancer therapy, an in-depth exploration strategies activated both internal external stimuli. We analyze implications tunable characteristics on pharmacokinetics, biodistribution, targeted TME. Additionally, we address current clinical translation nanocarriers propose overcome obstacles enhance feasibility nanomedicine-based

Language: Английский