Exploring Anticancer Activity and DNA Binding of Metal (II) Salicylaldehyde Schiff Base Complexes: A Convergence of Experimental and Computational Perspectives DOI Creative Commons
Ibrahim Waziri, Sheldon Sookai, Tunde L. Yusuf

et al.

Applied Organometallic Chemistry, Journal Year: 2025, Volume and Issue: 39(5)

Published: April 9, 2025

ABSTRACT Metal complexes derived from salicylaldehyde‐based Schiff bases are among the frontrunners in pursuit of precise and potent cancer treatments due to their remarkable prowess. In this study, base ( HL ) was prepared via a reaction between 2‐amino‐5‐benzonitrile salicylaldehyde. Subsequently, further reacted with Ni (II), Co Cu (II) Pd ions using respective metal salts obtain homoleptic mononuclear C1 – C4 ). The composition were determined 1 H 13 C NMR, UV–Vis, FTIR, CHN, SEM–EDX HRMS analyses. addition, structural geometries , C3 solid state single crystal X‐ray diffraction analysis corroborate mentioned characterization techniques employed. stability compounds assessed through time‐dependent UV–vis spectroscopy, revealing that C2 exhibited highest under experimental conditions. anticancer effects tested on breast cell lines (MCF‐7) MTT, LDH ATP assays. Both displayed potential cytotoxicity MCF‐7 line, which better inhibition effect than standard chemotherapeutic agent, doxorubicin (DOX), IC 50 43.08 μM. We postulate mechanism by may function is binding DNA = 0.114 (± 0.02) × 10 4 intercalation (shown UV‐CD UV‐LD spectroscopy) at AT rich sites. These data corroborated silico extra precision (XP) docking molecular dynamic (MD) simulations.

Language: Английский

Exploring Anticancer Activity and DNA Binding of Metal (II) Salicylaldehyde Schiff Base Complexes: A Convergence of Experimental and Computational Perspectives DOI Creative Commons
Ibrahim Waziri, Sheldon Sookai, Tunde L. Yusuf

et al.

Applied Organometallic Chemistry, Journal Year: 2025, Volume and Issue: 39(5)

Published: April 9, 2025

ABSTRACT Metal complexes derived from salicylaldehyde‐based Schiff bases are among the frontrunners in pursuit of precise and potent cancer treatments due to their remarkable prowess. In this study, base ( HL ) was prepared via a reaction between 2‐amino‐5‐benzonitrile salicylaldehyde. Subsequently, further reacted with Ni (II), Co Cu (II) Pd ions using respective metal salts obtain homoleptic mononuclear C1 – C4 ). The composition were determined 1 H 13 C NMR, UV–Vis, FTIR, CHN, SEM–EDX HRMS analyses. addition, structural geometries , C3 solid state single crystal X‐ray diffraction analysis corroborate mentioned characterization techniques employed. stability compounds assessed through time‐dependent UV–vis spectroscopy, revealing that C2 exhibited highest under experimental conditions. anticancer effects tested on breast cell lines (MCF‐7) MTT, LDH ATP assays. Both displayed potential cytotoxicity MCF‐7 line, which better inhibition effect than standard chemotherapeutic agent, doxorubicin (DOX), IC 50 43.08 μM. We postulate mechanism by may function is binding DNA = 0.114 (± 0.02) × 10 4 intercalation (shown UV‐CD UV‐LD spectroscopy) at AT rich sites. These data corroborated silico extra precision (XP) docking molecular dynamic (MD) simulations.

Language: Английский

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