Biological effects of high-LET irradiation on the circulatory system DOI
Yumi SAIGUSA, Mark P. Little, Omid Azimzadeh

et al.

International Journal of Radiation Biology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 24

Published: March 10, 2025

High-linear energy transfer (LET) radiation is generally thought to be more biologically effective in various tissues than low-LET radiation, but whether this also applies the circulatory system remains unclear. We therefore reviewed biological studies about effects of high-LET on system. identified 76 relevant papers (24 vitro, 2 ex vivo, 51 one overlapping). In vitro used human, bovine, porcine or chick vascular endothelial cells cardiomyocytes, while vivo hearts. mice, rats, rabbits, dogs pigs. The types were neutrons, α particles, heavy ions and negative pions. Most a single dose, although some investigated fractionation effects. Twenty-one estimated relative effectiveness (RBE) that ranged from 0.1 130, depending quality endpoint. A meta-analysis 6 8 (selected based feasibility estimating RBE its uncertainty) suggested an 6.69 (95% confidence intervals (CI): 2.51, 10.88) for 1.14 CI: 0.91, 1.37) studies. these 14 yielded 2.88 1.52, 4.25). This suggests only slightly substantial inter-study heterogeneity complicates interpretation. Therapeutic have been reported disease models. Further research needed better understand cardiovascular improve protection.

Language: Английский

Responses of the carotid artery to acute, fractionated or chronic ionizing irradiation, and differences from the aorta DOI Creative Commons
Nobuyuki Hamada, Ki-ichiro Kawano, Seiko Hirota

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: March 5, 2025

The circulatory system receives ionizing radiation at various dose rates. Given mounting epidemiological evidence of elevated risks for diseases the (DCS), International Commission on Radiological Protection recently recommended first ever threshold DCS. However, very little knowledge exists about whether effects differ with rates and among tissues system. Here, we investigated impact in carotid artery (CA) compared it aorta. CA was obtained from mice irradiated same total that delivered either acutely, 25 fractions, 100 fractions or chronically. underwent immunofluorescence histochemistry staining. Irradiation led to vascular damage, inflammation fibrosis CA. integrative analysis 14 prelesional endpoints revealed magnitude changes greater smaller much chronic irradiation, acute irradiation. Radiation responses aorta were qualitatively similar to, but quantitatively than those causes sparing enhancing protraction a manner is not simple function rate, radiosensitivity varies within

Language: Английский

Citations

1
Biological effects of high-LET irradiation on the circulatory system DOI
Yumi SAIGUSA, Mark P. Little, Omid Azimzadeh

et al.

International Journal of Radiation Biology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 24

Published: March 10, 2025

High-linear energy transfer (LET) radiation is generally thought to be more biologically effective in various tissues than low-LET radiation, but whether this also applies the circulatory system remains unclear. We therefore reviewed biological studies about effects of high-LET on system. identified 76 relevant papers (24 vitro, 2 ex vivo, 51 one overlapping). In vitro used human, bovine, porcine or chick vascular endothelial cells cardiomyocytes, while vivo hearts. mice, rats, rabbits, dogs pigs. The types were neutrons, α particles, heavy ions and negative pions. Most a single dose, although some investigated fractionation effects. Twenty-one estimated relative effectiveness (RBE) that ranged from 0.1 130, depending quality endpoint. A meta-analysis 6 8 (selected based feasibility estimating RBE its uncertainty) suggested an 6.69 (95% confidence intervals (CI): 2.51, 10.88) for 1.14 CI: 0.91, 1.37) studies. these 14 yielded 2.88 1.52, 4.25). This suggests only slightly substantial inter-study heterogeneity complicates interpretation. Therapeutic have been reported disease models. Further research needed better understand cardiovascular improve protection.

Language: Английский

Citations

0