Evaluating the Evidence Behind Multidisciplinary Roles for A Multiple Sclerosis Unit: A Systematic Literature Review

Multiple Sclerosis and Related Disorders, Journal Year: 2025, Volume and Issue: 95, P. 106342 - 106342

Published: Feb. 19, 2025

Multiple sclerosis (MS) is a primary cause of non-traumatic disability in young adults, affecting cognitive, motor, sensory, and emotional functions. Current pharmacological treatments offer limited benefits reversing existing damage, emphasizing the need for comprehensive care approach. Whilst multidisciplinary team (MDT) widely accepted, evidence supporting each potential member an ideal MS unit not currently clear. A systematic literature review following PRISMA guidelines was conducted, focusing on original research studies from past decade that discuss role MDTs or specific healthcare professionals care. Databases searched included PubMed EMBASE. Studies were screened selected based predefined inclusion exclusion criteria, data extracted study objectives, methods, outcomes. The initial search yielded 428 results 282 EMBASE, resulting total 710 records. Of these, 98 found to be duplicates. 612 papers screened, 565 excluded. remaining 47 assessed eligibility, 20 various countries highlight improved outcomes with involving neurologists, nurses, physiotherapists, occupational therapists, psychologists, other specialists. supports integration diverse However, gaps exist research, particularly regarding therapy standardization inpatient rehabilitation practices. This demonstrated use approach care, therefore favour concept optimise has also highlighted areas where future may needed members their unit.

Language: Английский

---

Cognitive impairment in multiple sclerosis: from phenomenology to neurobiological mechanisms

Journal of Neural Transmission, Journal Year: 2024, Volume and Issue: 131(8), P. 871 - 899

Published: May 18, 2024

Language: Английский

---

Exploring the Pathophysiology, Diagnosis, and Treatment Options of Multiple Sclerosis

Journal of Integrative Neuroscience, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 21, 2025

The complicated neurological syndrome known as multiple sclerosis (MS) is typified by demyelination, inflammation, and neurodegeneration in the central nervous system (CNS). Managing this crippling illness requires an understanding of complex interactions between neurophysiological systems, diagnostic techniques, therapeutic methods. A series processes, including immunological dysregulation, neurodegeneration, are involved pathogenesis MS. Gene predisposition, autoreactive T cells, B cytokines essential participants development disease. Demyelination interferes with ability CNS to transmit signals, which can cause a variety symptoms, impaired motor function, sensory deficiencies, cognitive decline. Developing tailored therapeutics underlying processes guiding course Neuroimaging, laboratory testing, clinical examination all necessary for accurate MS diagnosis. Evoked potentials cerebrospinal fluid studies assist verifying diagnosis, but magnetic resonance imaging (MRI) identifying distinctive lesions CNS. Novel biomarkers have potential increase precision forecast prognosis. goals treatment options control lower disease activity, enhance quality life. To stop relapses reduce disease, disease-modifying treatments (DMTs) target several components immune response. DMTs that now on market include interferons, glatiramer acetate, monoclonal antibodies, oral immunomodulators; each has unique mode action safety profile. Symptomatic improve patients' general well-being addressing specific pain, sphincter disorders, fatigue, spasticity. targets, neuroprotective tactics, personalized medicine techniques will be main focus research future. Improving long-term outcomes patients optimizing may possible utilizing immunology, genetics, neuroimaging developments. This study concludes highlighting complexity MS, its changing landscape, problems, foundations. thorough grasp these elements improving our capacity identify, manage, eventually overcome intricate condition.

Language: Английский

---

An interdisciplinary approach is necessary in the treatment of cognitive decline in multiple sclerosis – YES

Multiple Sclerosis Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

Language: Английский

---

Enhancing quality of life in multiple sclerosis: A study protocol to evaluate the impact of a therapeutic education program

Journal of Education and Health Promotion, Journal Year: 2025, Volume and Issue: 14(1)

Published: Feb. 1, 2025

Multiple sclerosis (MS) is a chronic inflammatory condition that causes lesions leading to both physical and psychological impairments, significantly affecting daily life. Therapeutic education has been identified as valuable approach in managing diseases, including MS. This study aims develop structured therapeutic protocol specifically for MS patients, with the goal of demonstrating its positive effects on quality prospective, descriptive will examine program life patients. The be conducted at Rabat University Hospital’s Physical Medicine Rehabilitation Neurology departments. Participants undergo individualized educational sessions interactive workshops. Evaluations performed baseline, 3 months, 6 months using Sclerosis Quality Life-54 (MSQOL-54) Measure Urinary Handicap (M.H.U) scale. Effective management necessitates personalized care strategies, education, which can enhance patient knowledge, self-management, overall provide insights into how interventions impact outcomes. outlines an investigation By addressing disease understanding, symptom management, psychosocial support, seeks improve patients’ Future research should assess long-term such compare their efficacy other approaches.

Language: Английский

---

Telerehabilitation and onsite rehabilitation effectively improve quality of life, fatigue, balance, and cognition in people with multiple sclerosis: an interventional study

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 8, 2024

Background Telerehabilitation (TR) offers a valuable opportunity to improve access care and has shown results comparable onsite rehabilitation (SR) across different conditions. The present study aimed explore the efficacy of TR SR in improving clinically meaningful outcomes people with multiple sclerosis (pwMS). Materials methods Subjects enrolled were assigned one two treatment arms: 6-week intervention or intervention. Pre-and post-intervention evaluation included assessment global wellbeing using Multiple Sclerosis Quality Life-54 scale (QoL), fatigue Fatigue Severity Status (FSS), cognitive status Symbol Digit Modalities Test (SDMT), balance dysfunction Berg Balance Scale (BBS). Group-level single-subject improvements considered as outcome measures, QoL primary endpoint. To determine significant group changes over time for entire pwMS cohort, paired t -test was applied overall score, focusing on both physical mental composites. An independent sample used assess differences baseline follow-up performance, well between groups (TR SR). This same analysis repeated other clinical domains (FSS, BBS, SDMT). minimal important difference (MCID) according vs. SR) explored logistic regression. Additionally, linear regression model evaluate impact clinical-demographic features observed modifications. Results A total 51 subjects completed (37 women, mean age 46.3 ± 9.8, median Expanded Disability 3.5, min. 2, max. 6.5). benefited from treatment, at individual levels all measured life improved significantly (p = 0.005), did (both p < 0.001), cognition 0.003). Conclusions Both approaches effectively perception fatigue, balance, quality population MS patients moderate disability.

Language: Английский

---

A Systematic Review of the Long-Term Effects of Using Smartphone- and Tablet-Based Rehabilitation Technology for Balance and Gait Training and Exercise Programs

Bioengineering, Journal Year: 2023, Volume and Issue: 10(10), P. 1142 - 1142

Published: Sept. 28, 2023

Recent advances in wearable motion sensors, mobile devices, the Internet of Things, and telecommunications have created new potential for telerehabilitation. Recognizing that there is no systematic review smartphone- or tablet-based balance gait telerehabilitation technology long-term use (i.e., four weeks more), this summarizes effects rehabilitation on exercise training disorders. The examined studies written English published from 2013 to 2023 Web Science, Pubmed, Scopus, Google Scholar. Of 806 identified, 14 were selected, National Institutes Health Quality Assessment Tool Observational Cohort Cross-sectional Studies was applied evaluate methodological quality. concluded all found performance improvement after more Ten carry-over (improved functional movements, muscle strength, motor capacity, cognition, reduced fear falling anxiety levels) maintained months. results positive technical clinical implications next-generation design programs.

Language: Английский

---

Illness representation in patients with multiple sclerosis: A preliminary narrative medicine study

Multiple Sclerosis Journal - Experimental Translational and Clinical, Journal Year: 2024, Volume and Issue: 10(3)

Published: July 1, 2024

Background The development of personalized interventions aimed at coping with multiple sclerosis is enriched by the understanding patients’ representations illness. Objective aim this study was to investigate association between illness versus contextual factors (i.e. presence/absence and type caregiver, engagement, frequency rehabilitation), fatigue, pain, neurological impairment. Methods Interviews 28 patients were analysed through an automated text analysis procedure. After a systematic labelling procedure four identified: daily life, search for meaning disease, relationship people diagnosis, physical growth. Results Findings showed that representation relational aspects associated caregiver's presence, while related growth tended be participation in rehabilitation programs. Moreover, life lower levels fatigue compared growth, higher impairment Conclusion Exploring key step can help health professionals get integrated perspective could useful designing calibrating according specific patient needs.

Language: Английский

---

To halt disease progression rehabilitation in MS should start early: Yes

Multiple Sclerosis Journal, Journal Year: 2024, Volume and Issue: 30(13), P. 1592 - 1594

Published: Nov. 1, 2024

Language: Английский

---

An Internet- and Kinect-Based Multiple Sclerosis Fitness Intervention Training With Pilates Exercises: Development and Usability Study

JMIR Serious Games, Journal Year: 2023, Volume and Issue: 11, P. e41371 - e41371

Published: July 30, 2023

Balance impairments are common in people with multiple sclerosis (MS), reduced ability to maintain position and delayed responses postural adjustments. Pilates is a popular alternative method for balance training that may reduce the rapid worsening of symptoms increased risk secondary conditions (eg, depression) frequently associated physical inactivity.In this paper, we aimed describe design, development, usability testing MS Fitness Intervention Training (MS-FIT), Kinect-based tool implementing exercises customized MS.MS-FIT has been developed using user-centered design approach (design, prototype, user feedback, analysis) gain target user's perspective. A team composed 1 therapist, 2 game programmers, designer first version MS-FIT integrated knowledge experience literature findings related interventions based on exergames. MS-FIT, by Unity 3D (Unity Technologies) engine software Kinect Sensor V2 Windows, implements breathing, posture, balance. Feedback from an Italian panel experts rehabilitation (neurologists, physiatrists, therapists, statistician, bioengineer) was collected customize use MS. The context traveling around world visit some most important cities learn aspects their culture through pictures stories. At each stay travel, avatar teacher shows be performed. Overall, 9 (n=4, 44% women; mean age 42.89, SD 11.97 years; disease duration 10.19, 9.18 Expanded Disability Status Scale score 3.17, 0.75) were involved 3 outpatient test sessions 30 minutes; MS-FIT's assessed ad hoc questionnaire (maximum value=5; higher score, usability) evaluating easiness use, playability, enjoyment, satisfaction, acceptance.A used develop accessible challenging training. All (9/9, 100%) completed answered questionnaire. average item ranged 3.78 (SD 0.67) 4.33 1.00), which indicated high level. feedback suggestions provided 64% (9/14) 36% (5/14) therapists implemented refine prototype release 2.0.The participants reported usable tool. It promising system enhancing motivation engagement performing exercise aim improving status.

Language: Английский

---