Associations between dairy and alcohol consumption and major depressive disorder in a mendelian randomization study DOI Creative Commons

Dan Qiu,

Ren‐Jie Song,

Xuejing Cao

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Nov. 19, 2024

This study explored the link between diet and major depressive disorder (MDD) to provide fresh insights for MDD prevention. Single nucleotide polymorphisms (SNPs) associated with common foods, such as meat, bread, cheese, fruits, cereals, vegetables, four alcohol intake categories, were leveraged instrumental variables. Accordingly, this employed inverse variance weighting (IVW) method evaluate genetically predicted associations of different food phenotypes risk. The sensitivity analysis involved MR‒Egger regression Mendelian random polymorphism residuals, along outlier tests, assess variable pleiotropy. Additional methods, MR‒Egger, weighted median method, model, used validate robustness reliability findings. results univariable randomization(UVMR) using IVW indicated that consumption cheese [OR = 0.841, 95% CI: 0.737–0.959, P 0.0099], dried fruit 0.7922, 0.644–0.973, 0.0264], beer 1.284, 1.026–1.608, 0.0291], spirits 3.837, 1.993–7.387, 0.0001] significantly risk developing disorder. Specifically, exhibited a correlation risk, whereas showed positive correlation, showing stronger correlation. Fourteen other including red wine, white displayed no significant association occurrence depression through either type intake. In multivariable randomization(MVMR) analysis, considering potential confounding factors insomnia, smoking, use contraceptive pills, was identified have an independent causal relationship (OR: 0.754, 0.591–0.962, p 0.0229). No relationships fruit, beer, or MDD. reverse randomization (rMR) did not effect on spirits, supporting presence unidirectional relationship. Finally, examined dietary characteristics, per capita intake, incidence among residents Shanghai, Peking, Guangdong Provinces Asian ethnicity in China. These findings align conclusions drawn from suggesting maintaining diverse diet, sensibly consuming reducing spirit may prevent

Language: Английский

Prevalence, Determinants and Wealth‐Related Inequality of Anxiety and Depression Symptoms Among Reproductive‐Aged Women (15–49 Years) in Nepal: An Analysis of Nationally Representative Nepal Demographic and Health Survey Data 2022 DOI Creative Commons
Syed Toukir Ahmed Noor,

Samin Yeasar,

S Siddique

et al.

Depression and Anxiety, Journal Year: 2025, Volume and Issue: 2025(1)

Published: Jan. 1, 2025

Background: Mental health issues, particularly anxiety and depression, among women of reproductive age, remain a significant public concern, yet comprehensive studies addressing these issues are limited in Nepal. Objective: This study aimed to assess the prevalence, associated factors wealth‐related inequality depression symptoms aged 15–49 years Methods: Data from Nepal Demographic Health Survey (NDHS) 2022 included 7410 women. Logistic regression analysis was conducted identify with anxiety, combined symptoms. We also employed concentration curve disparities mental outcomes. Findings: The prevalence 5.4% (95% CI: 4.8% 6.2%) 7.5% 6.7% 8.4%), respectively. Furthermore, 9.1% 8.2% 10.1%) experienced either condition, while 3.8% 3.3% 4.4%) both. Women lower educational attainment, higher number children, unemployed partners, residents rural areas those living Karnali province exhibited mass media exposure were risk Additionally, tobacco habits demonstrated significantly depression. Finally, evident; socioeconomic status more vulnerable Conclusions: highlights need for targeted interventions socio‐economic determinants lifestyle factors, including use, mitigate burden

Language: Английский

Citations

1
MS care: integrating advanced therapies and holistic management DOI Creative Commons
Gavin Giovannoni, Helen Ford, Klaus Schmierer

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 14

Published: Jan. 30, 2024

Lifestyle and environmental factors are key determinants in disease causality progression neurological conditions, including multiple sclerosis (MS). Lack of exercise, poor diet, tobacco smoking, excessive alcohol intake, social health, concomitant medications, sleep comorbidities can exacerbate MS pathological processes by impacting brain health depleting reserves, resulting more rapid worsening. In addition to using disease-modifying therapies alter the course, therapeutic strategies should aim preserve as much reserve possible promoting adoption a “brain-healthy” “metabolically-healthy” lifestyle. Here, we recommend self-regulated lifestyle modifications that have potential improve directly impact on outcomes people with MS. We emphasise importance self-management adopting multidisciplinary, collaborative person-centred approach care encompasses healthcare team, family members community support groups.

Language: Английский

Citations

8
Immunopathogenesis of multiple sclerosis: molecular and cellular mechanisms and new immunotherapeutic approaches DOI
Mansur Aliyu, Fatema Tuz Zohora, Ayça Ceylan

et al.

Immunopharmacology and Immunotoxicology, Journal Year: 2024, Volume and Issue: 46(3), P. 355 - 377

Published: April 18, 2024

Background: Multiple sclerosis (MS) is a central nervous system (CNS) demyelinating autoimmune disease with increasing global prevalence. It predominantly affects females, especially those of European descent. The interplay between environmental factors and genetic predisposition plays crucial role in MS etiopathogenesis.

Language: Английский

Citations

7
Depression and anxiety in multiple sclerosis. Review of a fatal combination DOI
K. A. Jellinger

Journal of Neural Transmission, Journal Year: 2024, Volume and Issue: 131(8), P. 847 - 869

Published: June 13, 2024

Language: Английский

Citations

5
Understanding Depression in People Living with Multiple Sclerosis: A Narrative Review of Recent Literature DOI Creative Commons
Amy B. Sullivan, Bryan E. Davis,

Julie K. Kidd

et al.

Neurology and Therapy, Journal Year: 2025, Volume and Issue: unknown

Published: March 27, 2025

Multiple sclerosis (MS) is a chronic neurodegenerative and autoimmune disease that affects approximately 1 million adults in the US. Psychologic disorders are typical comorbidities people with MS (pwMS), depression being most common. Clinical pwMS can substantially impact quality of life factor heavily treatment adherence. Depression surface early MS, becoming more prevalent as progresses severity clinical disability increases. The etiology comorbid not completely understood, but recent research has indicated structural functional brain abnormalities, along genetic immunologic factors, may contribute to pathogenesis pwMS. Although significant on pwMS, it often underdiagnosed undertreated. Furthermore, efficacy pharmacologic non-pharmacologic approaches for treating been thoroughly investigated, studies showing minimal or no beneficial effect. Improved evaluation diagnosis better understanding its pathophysiology provide stronger foundation management suffering from depression. This review discusses potential causes depression, risk factors associated developing overall It also reviews patient-reported outcomes utilized assess disease-modifying therapies Consideration given (both non-pharmacologic) facilitate patient journey.

Language: Английский

Citations

0
Baseline engagement with healthy lifestyles and their associations with health outcomes in people with multiple sclerosis enrolled in an online multimodal lifestyle course DOI Creative Commons
Maggie Yu, Sandra Neate, Nupur Nag

et al.

European Journal of Neurology, Journal Year: 2024, Volume and Issue: 31(10)

Published: Aug. 7, 2024

Healthy lifestyle behaviour modification may improve health outcomes in people with multiple sclerosis (pwMS), but empirical evidence is needed to confirm prior study findings. We developed an online multimodal intervention (Multiple Sclerosis Online Course) examine the impact of on pwMS via a randomized control trial (RCT). However, present specifically analyses baseline data assess engagement healthy lifestyles by RCT participants and cross-sectional associations outcomes.

Language: Английский

Citations

2
Smoking affects epigenetic ageing of lung bronchoalveolar lavage cells in Multiple Sclerosis DOI Creative Commons
Dennis Klose,

Maria Needhamsen,

Mikael V. Ringh

et al.

Multiple Sclerosis and Related Disorders, Journal Year: 2023, Volume and Issue: 79, P. 104991 - 104991

Published: Sept. 9, 2023

A compelling body of evidence implicates cigarette smoking and lung inflammation in Multiple Sclerosis (MS) susceptibility progression. Previous studies have reported epigenetic age (DNAm age) acceleration blood immune cells glial people with MS (pwMS) compared to healthy controls (HC).We aimed examine biological ageing the context smoking.We analyzed residuals bronchoalveolar lavage (BAL) cells, constituted mainly alveolar macrophages, from 17 pwMS 22 HC relation using eight DNA methylation-based clocks, namely AltumAge, Horvath, GrimAge, PhenoAge, Zhang, SkinBlood, Hannum, Monocyte clock as well two RNA-based which capture different aspects ageing.After adjustment for covariates, five clocks showed significant differences between groups. Four them, Horvath (Padj = 0.028), GrimAge 4.28 × 10-7), SkinBlood 0.001) Zhang 0.02), uncovered sole effect on estimates, irrespective clinical group. The a negative impact while detected smoking-associated BAL cells. On contrary, AltumAge revealed indicated that, absence smoking, were epigenetically 5.4 years older 0.028). Smoking further affected specifically non-smoking exhibited 10.2-year smokers 0.0049). Of note, blood-derived monocytes did not show any MS-specific or smoking-related differences. difference non-smokers was attributable differential methylation 114 AltumAge-CpGs < 0.05) affecting genes involved innate processes such cytokine production, defense response cell motility. These changes functionally translated into transcriptional non-smokers.BAL display inflammation-related smoking-dependent associated captured by clock. Future examining potential confounders, distribution distinct myeloid types control individuals may clarify varying performance DNAm estimations among clocks.

Language: Английский

Citations

6
The Barancik lecture: Comorbidity in multiple sclerosis—Looking backward, looking forward DOI Creative Commons
Ruth Ann Marrie

Multiple Sclerosis Journal, Journal Year: 2023, Volume and Issue: 29(9), P. 1049 - 1056

Published: April 26, 2023

Comorbidity is highly prevalent in people with multiple sclerosis (MS) throughout their disease course. In the last 15 years, our understanding of association between comorbidity and outcomes such as relapses, disability progressive, health-related quality life, health care use, mortality has grown substantially. The broad adverse impacts on these point to need prevent treat effectively MS. This requires having necessary tools evaluate comorbidity, an how MS affects management now, testing interventions tailored MS, determining best models optimize management.

Language: Английский

Citations

5
The mediating role of negative emotions in the relationship between smoking and health-related quality of life among Chinese individuals: A cross-sectional study DOI Creative Commons

Zhenni Luo sup sup,

Weihong Xu sup sup,

Shijing Jiang

et al.

Tobacco Induced Diseases, Journal Year: 2023, Volume and Issue: 21(October), P. 1 - 12

Published: Oct. 16, 2023

Although the negative impact of smoking on health has been confirmed in various studies, few have explored psychological factors mediating relationship between and health-related quality life (HRQOL). This study aimed to investigate HRQOL Chinese population role emotions (NEs).Survey data were derived from a cross-sectional conducted China 20 June 31 August 2022. We recruited participants 148 cities across country using stratified multistage sampling method. The dependent variable was measured version European Quality Life-5 Dimensions (EQ-5D-5L). Patient Health Questionnaire (PHQ-9), Generalized Anxiety Disorder (GAD-7), Perceived Stress Scale (PSS-4) used measure NE parameters including depression, anxiety, perceived stress, as intermediate variables. A multiple parallel mediation model analyze NEs HRQOL.A total 21916 valid questionnaires collected, which 3010 (13.7%) 18906 (86.3%) categorized into smokers non-smokers, respectively. (EQ-VAS score) (71.70 ± 23.08) lower than that non-smokers (73.69 21.32), whereas depression anxiety levels higher those (all p<0.001). Moreover, smoking, (depression anxiety), showed pairwise correlations. According analysis, (β= -0.461; 95% BCa CI: -0.664 - -0.268) -0.279; -0.435 -0.138) mediated after adjusting for demographic factors.These findings emphasize necessity studying interaction HRQOL, Nes, complementing research smokers. Public activities should focus mental take targeted measures prevention, treatment, rehabilitation

Language: Английский

Citations

5
Prevalence and associated factors of depression, anxiety and stress among clinical therapists in China in the context of early COVID-19 pandemic DOI Creative Commons
Rui Tao, Wenzheng Li, Kaiyuan Min

et al.

Frontiers in Psychiatry, Journal Year: 2024, Volume and Issue: 15

Published: Feb. 23, 2024

Objectives To study the socio-demographic characteristics and prevalence of depression, anxiety, stress among clinical therapists in China during early Coronavirus disease 2019 (COVID-19) pandemic to identify associated factors. Method This cross-sectional was part a multicenter, nationally representative survey conducted through WeChat from January 2021 March 2021. Data, including socio-demographics, health-related behaviors, information on whether they participated frontline work treating COVID-19, were collected anonymously. Respondents also completed Depression Anxiety Stress Scales-21 (DASS-21). Results In total, 396 selected hospitals questionnaires, with response rate 89.0%. predominantly female (77.3%). About 6.6% participants current tobacco users, 20.7% had COVID-19. Overall, 22.0%, 17.9%, 8.8% classified as having clinically meaningful stress, respectively, based DASS-21 scores. Multiple logistic regression Model 1 2 showed that regular physical activity frequent insomnia (all, p &lt; 0.05). anxiety model 2, factors for identified education (master’s degree or more, OR=0.520; 95% CI=0.283-0.955), marital status (single, OR=2.064; CI=1.022-4.168), use (OR=4.265; CI=1.352-13.454), (OR=0.357; CI=0.192-0.663), (OR=6.298; CI =2.522-15.729), participation COVID-19 (OR=3.179; CI=1.697-5.954). The epidemic did not significantly increase depression levels therapists, but it levels. Conclusion During pandemic, relatively common China. Regular good sleep important protective against emotional problems. Therefore, encouraging actively addressing therapists’ problems is beneficial improving ability cope negative emotions. increased awareness interventions should be recommended reduce pandemic.

Language: Английский

Citations

1