Timed 25-foot walk test is independently associated with cognitive function in multiple sclerosis: a cross-sectional study DOI Creative Commons
Omid Mirmosayyeb, Saeed Vaheb, Ida Mohammadi

et al.

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: April 17, 2025

Cognitive impairment (CI) is prevalent among people with multiple sclerosis (PwMS), significantly affecting their quality of life and functional capacity. While the relationship between CI motor function has been explored in healthy aging other neurological conditions, its association upper lower PwMS remains underexplored. This cross-sectional study analyzed data from 125 (Mage: 37.6 years; median disease duration: 8 years) to examine cognitive outcomes. status was evaluated using Symbol Digit Modalities Test (SDMT), California Verbal Learning Test-Second Edition (CVLT-II), Brief Visuospatial Memory Test-Revised (BVMT-R). Motor assessed 9-Hole Peg (9-HPT) Timed 25-Foot Walk (T25FW). Hierarchical regression models identified significant predictors performance. Multivariate analyses revealed that T25FW strongest predictor SDMT (β = - 3.10, p < 0.001), CVLT-II 2.91, BVMT-R 1.98, 0.001). Additional included duration (SDMT: β 0.26, 0.033; CVLT-II: 0.28, 0.048; BVMT-R: 0.23, 0.037) education (BVMT-R: 0.60, 0.004). EDSS a for 1.42, 0.029). The 9-HPT not independently associated status. emerged as robust processing speed, verbal memory, visuospatial underscoring value practical assessment tool correlating PwMS.

Language: Английский

Association Between Diffusion Tensor Imaging Measurements and Cognitive Performances in People with Multiple Sclerosis: A Systematic Review and Meta-analysis DOI
Omid Mirmosayyeb, Mohammad Yazdan Panah, Saeed Vaheb

et al.

Multiple Sclerosis and Related Disorders, Journal Year: 2025, Volume and Issue: 94, P. 106261 - 106261

Published: Jan. 6, 2025

Language: Английский

Citations

1
The relationship between optical coherence tomography and magnetic resonance imaging measurements in people with multiple sclerosis: A systematic review and meta-analysis DOI
Omid Mirmosayyeb, Mohammad Yazdan Panah, Elham Moases Ghaffary

et al.

Journal of the Neurological Sciences, Journal Year: 2025, Volume and Issue: 470, P. 123401 - 123401

Published: Jan. 21, 2025

Language: Английский

Citations

1
Imaging Correlates of Plaque Location and Cognitive Dysfunction in Multiple Sclerosis DOI Creative Commons

Mohamad Ghazanfari Hashemi,

Ahmad Enhesari

Thrita journal of neuron., Journal Year: 2025, Volume and Issue: 13(2)

Published: Feb. 22, 2025

Background: Cognitive dysfunction plays a significant role in the disease course of multiple sclerosis (MS), yet imaging correlates these cognitive changes are not fully understood. Objectives: This study explores association between plaque location on magnetic resonance (MRI) and MS. Methods: cross-sectional involved 100 subjects diagnosed with relapsing-remitting MS (RRMS), aged 18 - 55 years, who underwent brain MRI March 2020 2024 at Besat Clinic Imaging Center, Kerman, Iran. function was assessed using montreal assessment (MoCA) within one week MRI. The relationship impairment analyzed SPSS version 25. Results: Of total participants, 76% were categorized as cognition preserved (CP) 24% impaired (CI). No differences average age, duration, treatment or comorbidities found CP CI patients. However, patients had significantly more demyelinating plaques frontal lobe corpus callosum (P = 0.006 for lobe, P 0.004 callosum) compared to Conclusions: distribution may contribute

Language: Английский

Citations

0
Timed 25-foot walk test is independently associated with cognitive function in multiple sclerosis: a cross-sectional study DOI Creative Commons
Omid Mirmosayyeb, Saeed Vaheb, Ida Mohammadi

et al.

European journal of medical research, Journal Year: 2025, Volume and Issue: 30(1)

Published: April 17, 2025

Cognitive impairment (CI) is prevalent among people with multiple sclerosis (PwMS), significantly affecting their quality of life and functional capacity. While the relationship between CI motor function has been explored in healthy aging other neurological conditions, its association upper lower PwMS remains underexplored. This cross-sectional study analyzed data from 125 (Mage: 37.6 years; median disease duration: 8 years) to examine cognitive outcomes. status was evaluated using Symbol Digit Modalities Test (SDMT), California Verbal Learning Test-Second Edition (CVLT-II), Brief Visuospatial Memory Test-Revised (BVMT-R). Motor assessed 9-Hole Peg (9-HPT) Timed 25-Foot Walk (T25FW). Hierarchical regression models identified significant predictors performance. Multivariate analyses revealed that T25FW strongest predictor SDMT (β = - 3.10, p < 0.001), CVLT-II 2.91, BVMT-R 1.98, 0.001). Additional included duration (SDMT: β 0.26, 0.033; CVLT-II: 0.28, 0.048; BVMT-R: 0.23, 0.037) education (BVMT-R: 0.60, 0.004). EDSS a for 1.42, 0.029). The 9-HPT not independently associated status. emerged as robust processing speed, verbal memory, visuospatial underscoring value practical assessment tool correlating PwMS.

Language: Английский

Citations

0