Effects of 16-week progressive resistance training on neurodegeneration in people with progressive multiple sclerosis: An extended baseline within-person trial DOI Creative Commons
Arianne S Gravesteijn, Heleen Beckerman, Tommy A.A. Broeders

et al.

Multiple Sclerosis and Related Disorders, Journal Year: 2025, Volume and Issue: unknown, P. 106411 - 106411

Published: March 1, 2025

Progressive multiple sclerosis (PMS) is characterized by ongoing neurodegeneration, which current therapies inadequately address. Exercise therapy has emerged as a potential approach to mitigate this process. To investigate the effects of 16-week progressive resistance training (PRT) on neurodegeneration and neuronal function in people with PMS. In extended-baseline within-person trial, were assessed (i.e. total brain volume (TBV), cortical deep gray matter (CGMV & DGMV) normalized for intercranial volume, default mode network (DMN) sensorimotor (SMN) resting-state functional connectivity blood-based biomarkers (brain-derived neurotrophic factor, neurofilament light, glial fibrillary acidic protein)). Muscle strength changes also measured. Linear mixed model analysis was used assess changes. Thirty participants (20 females; mean age 54 years) significantly improved muscle (3-11 kg). No significant observed nor function. CGMV demonstrated trend towards decline during baseline (-0.0008, 95 %CI:-0.0017, 0.0001, p = 0.10) intervention period (-0.0007, %CI:-0.0016, 0.10), but not follow-up (0.0002, %CI:-0.0007, 0.0011, 0.60). The PRT did affect Further research longer-term exercise interventions warranted.

Language: Английский

Effects of 16-week progressive resistance training on neurodegeneration in people with progressive multiple sclerosis: An extended baseline within-person trial DOI Creative Commons
Arianne S Gravesteijn, Heleen Beckerman, Tommy A.A. Broeders

et al.

Multiple Sclerosis and Related Disorders, Journal Year: 2025, Volume and Issue: unknown, P. 106411 - 106411

Published: March 1, 2025

Progressive multiple sclerosis (PMS) is characterized by ongoing neurodegeneration, which current therapies inadequately address. Exercise therapy has emerged as a potential approach to mitigate this process. To investigate the effects of 16-week progressive resistance training (PRT) on neurodegeneration and neuronal function in people with PMS. In extended-baseline within-person trial, were assessed (i.e. total brain volume (TBV), cortical deep gray matter (CGMV & DGMV) normalized for intercranial volume, default mode network (DMN) sensorimotor (SMN) resting-state functional connectivity blood-based biomarkers (brain-derived neurotrophic factor, neurofilament light, glial fibrillary acidic protein)). Muscle strength changes also measured. Linear mixed model analysis was used assess changes. Thirty participants (20 females; mean age 54 years) significantly improved muscle (3-11 kg). No significant observed nor function. CGMV demonstrated trend towards decline during baseline (-0.0008, 95 %CI:-0.0017, 0.0001, p = 0.10) intervention period (-0.0007, %CI:-0.0016, 0.10), but not follow-up (0.0002, %CI:-0.0007, 0.0011, 0.60). The PRT did affect Further research longer-term exercise interventions warranted.

Language: Английский

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