Synthesis, Characterization, Density Functional Theory Study, Antibacterial Activity and Molecular Docking of Zeolitic Imidazolate Framework‐8 DOI
Safdar Ali Amur, Bharat Prasad Sharma,

Najaf Ali Soomro

et al.

Applied Organometallic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

ABSTRACT In this study, Zeolitic Imidazolate Framework‐8 (ZIF‐8) nanomaterials were synthesized using a co‐precipitation one‐pot method that uses ethanol, methanol, and water as solvents for the precursors (2‐methylimidazole Zinc nitrate hexahydrate), resulting in yields of 66.77%, 73.14%, 68.12%, respectively. The as‐synthesized ZIF‐8 thoroughly characterized by X‐ray diffraction analysis, transmission electron microscopy, ultraviolet–visible spectroscopy, Fourier‐transform infrared spectroscopy. analysis showed crystallite size ethanol‐based (24.76 ± 1.67 nm) was smaller than those (26.92 1.89 methanol (31.39 1.03 nm). However, methanol‐based exhibited lower crystallinity (85.93%) water‐based (91.48%) (92.71%). Zeta potential studies revealed had larger surface charge (+37 mV) (+35 or (+24 mV). Transmission microscopy confirmed particle sizes 54.35 2.11 nm ZIF‐8, 57.91 2.26 63.25 4.12 ZIF‐8. Thermogravimetric indicated thermal stability up to 800 °C, with mass losses 55.98% ethanol‐ZIF‐8, 50.12% 65.36% 600 °C. antibacterial studies, largest zone growth inhibition (17.30 0.26 mm) against Escherichia coli compared (15.57 0.32 (14.70 0.20 mm). Pearson's correlation study zeta potential, crystallinity, activity are positively related. Furthermore, minimum inhibitory concentration 50 μg/100 μL, evident cell membrane disruption. Molecular docking experiments ZIF‐8's significant binding affinity E. protein 5AZC, supporting its robust activity.

Language: Английский

Machine Learning-Enhanced Electrochemical Sensors for Food Safety: Applications and Perspectives DOI

Wajeeha Pervaiz,

Muhammad Afzal,

Niu Feng

et al.

Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 104872 - 104872

Published: Jan. 1, 2025

Language: Английский

Citations

1
Biodegradation of PLA in surface water and its behavior towards PFOA: interactional characteristics and computational insights DOI

Sadam Hussain Tumrani,

Bharat Prasad Sharma,

Ali Raza Otho

et al.

Colloid & Polymer Science, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

Language: Английский

Citations

0
Synthesis, Characterization, Density Functional Theory Study, Antibacterial Activity and Molecular Docking of Zeolitic Imidazolate Framework‐8 DOI
Safdar Ali Amur, Bharat Prasad Sharma,

Najaf Ali Soomro

et al.

Applied Organometallic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

ABSTRACT In this study, Zeolitic Imidazolate Framework‐8 (ZIF‐8) nanomaterials were synthesized using a co‐precipitation one‐pot method that uses ethanol, methanol, and water as solvents for the precursors (2‐methylimidazole Zinc nitrate hexahydrate), resulting in yields of 66.77%, 73.14%, 68.12%, respectively. The as‐synthesized ZIF‐8 thoroughly characterized by X‐ray diffraction analysis, transmission electron microscopy, ultraviolet–visible spectroscopy, Fourier‐transform infrared spectroscopy. analysis showed crystallite size ethanol‐based (24.76 ± 1.67 nm) was smaller than those (26.92 1.89 methanol (31.39 1.03 nm). However, methanol‐based exhibited lower crystallinity (85.93%) water‐based (91.48%) (92.71%). Zeta potential studies revealed had larger surface charge (+37 mV) (+35 or (+24 mV). Transmission microscopy confirmed particle sizes 54.35 2.11 nm ZIF‐8, 57.91 2.26 63.25 4.12 ZIF‐8. Thermogravimetric indicated thermal stability up to 800 °C, with mass losses 55.98% ethanol‐ZIF‐8, 50.12% 65.36% 600 °C. antibacterial studies, largest zone growth inhibition (17.30 0.26 mm) against Escherichia coli compared (15.57 0.32 (14.70 0.20 mm). Pearson's correlation study zeta potential, crystallinity, activity are positively related. Furthermore, minimum inhibitory concentration 50 μg/100 μL, evident cell membrane disruption. Molecular docking experiments ZIF‐8's significant binding affinity E. protein 5AZC, supporting its robust activity.

Language: Английский

Citations

2