Natural flavones from edible and medicinal plants exhibit enormous potential to treat ulcerative colitis

Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14

Published: June 1, 2023

Ulcerative colitis (UC) is a chronic aspecific gut inflammatory disorder that primarily involves the recta and colons. It mostly presents as long course of repeated attacks. This disease, characterized by intermittent diarrhoea, fecal blood, stomachache, tenesmus, severely decreases living quality sick persons. UC difficult to heal, has high recurrence rate, tightly related incidence colon cancer. Although there are number drugs available for suppression colitis, conventional therapy possesses certain limitations severe adverse reactions. Thus, it extremely required safe effective medicines naturally derived flavones exhibited huge prospects. study focused on advancement from edible pharmaceutical plants treating colitis. The underlying mechanisms natural-derived in were closely linked regulation enteric barrier function, immune-inflammatory responses, oxidative stress, microflora, SCFAs production. prominent effects safety make them promising candidate treatment.

Language: Английский

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Multi-targeting inulin-based nanoparticles with cannabidiol for effective prevention of ulcerative colitis

Materials Today Bio, Journal Year: 2024, Volume and Issue: 25, P. 100965 - 100965

Published: Jan. 21, 2024

Language: Английский

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Chitosan-insulin nano-formulations as critical modulators of inflammatory cytokines and Nrf-2 pathway to accelerate burn wound healing

Discover Nano, Journal Year: 2023, Volume and Issue: 18(1)

Published: Dec. 12, 2023

Burn injuries are characterized by prolonged inflammatory phases, neurovascular damage, and hypermetabolism, eventually causing improper tissue regeneration. Insulin has gained considerable attention in normal diabetic wound healing, yet its role burn wounds remains poorly understood. In this study, insulin-chitosan nano-formulations (ICNP) were synthesized using a simple robust mechanism to monitor specific interactions between insulin chitosan, the particles measuring approximately 30 nm size exhibited mild alterations amide I, II, III bonds of protein along with impressive loading efficiency 88.725 ± 0.295% under physiological conditions, significantly improved healing vitro (HEKa cells) vivo (murine third-degree model). The underlying behind superior closure remodeling was attributed significant early phase reduction pro-inflammatory cytokine IL-6 levels ICNP-treated mice, while anti-inflammatory IL-10 became markedly elevated, resulting enhanced re-epithelialization collagen deposition. Furthermore, treatment ICNP associated unregulated expression Nrf-2, key regulator oxidative stress inflammation, indicating their molecular crosstalk. These findings highlight potential as promising therapeutic formulation for promoting modulating making it valuable candidate further clinical development care.

Language: Английский

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Caffeic Acid-Conjugated Budesonide-Loaded Nanomicelle Attenuates Inflammation in Experimental Colitis

Molecular Pharmaceutics, Journal Year: 2022, Volume and Issue: 20(1), P. 172 - 182

Published: Dec. 6, 2022

Ulcerative colitis is a multifactorial disease of the gastrointestinal tract which caused due to chronic inflammation in colon; it usually starts from lower end colon and may spread other portions large intestine, if left unmanaged. Budesonide (BUD) synthetically available second-generation corticosteroidal drug with potent local anti-inflammatory activity. The pharmacokinetic properties, such as extensive first-pass metabolism quite limited bioavailability, reduce its therapeutic efficacy. To overcome limitations, nanosized micelles were developed this study by conjugating stearic acid caffeic make an amphiphilic compound. aim present was evaluate pharmacological potential BUD-loaded mouse model dextran sulfate sodium-induced colitis. Micelles formulated solvent evaporation method, their physicochemical characterizations show spherical shape under microscopic techniques like atomic force microscopy, transmission electron scanning microscopy. vitro release experiment shows sustained behavior physiological media. These cytocompatible against hTERT-BJ cells up 500 μg/mL dose, evidenced more than 85% viable cells. successfully normalized activity index physical observation length. treatment alleviates severity analyzed histopathology efficiently, overcoming via downregulation various related cytokines (MPO, NO, TNF-α) inflammatory enzymes COX-2 iNOS. Results suggest that nano-sized effectively attenuate conditions

Language: Английский

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Recent advances on drug delivery nanoplatforms for the treatment of autoimmune inflammatory diseases

Materials Advances, Journal Year: 2022, Volume and Issue: 3(21), P. 7687 - 7708

Published: Jan. 1, 2022

As one of the current research hotspots, drug release nanoplatforms have great potential in treatment autoimmune inflammatory diseases.

Language: Английский

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