Nanomaterials for photothermal and photodynamic cancer therapy

Applied Physics Reviews, Journal Year: 2022, Volume and Issue: 9(1)

Published: March 1, 2022

In recent years, the role of optically sensitive nanomaterials has become powerful moieties in therapeutic techniques and particularly emphasized. Currently, by extraordinary development different fields medicine, they have found new applications. Phototherapy modalities, such as photothermal therapy (PTT) toxic heat generation photodynamic (PDT) reactive oxygen species, are known promising phototherapeutic techniques, which can overcome limitations conventional protocols. Moreover, nanomaterial-based PDT PTT match simultaneous immune increase system stimulation resulting from denaturation cancer cells. Nevertheless, should sufficient biocompatibility efficiency to meet requirements agents. The present review focuses on potency PDT, PTT, also their combined alternative protocols with minimal morbidity integrated into gold standard treatments surgery, chemotherapy, radiation at tumor treatment cancer-related infectious diseases. addition, for deeper understanding, photoablation effects emphasis nature, morphology, size photosensitive were studied. Finally, transportation needed carriers photosensitizers agents hard-accessed regions, example, cancerous investigated.

Language: Английский

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A Review of Bimetallic and Monometallic Nanoparticle Synthesis via Laser Ablation in Liquid

Crystals, Journal Year: 2023, Volume and Issue: 13(2), P. 253 - 253

Published: Feb. 1, 2023

Pulsed laser ablation in liquid (PLAL) is a physical and top-down approach used to fabricate nanoparticles (NPs). Herein, the research methods current trends PLAL literature are reviewed, including recent uses of for fabricating bimetallic (BNPs) composites. BNPs have gained attention owing their advanced physicochemical properties over monometallic NPs. involves irradiation solid target (usually rod, plate, or thin film) under medium. The collects ejected NPs resulting from processing, which produces colloid that can be various applications, plasmon sensing, energy harvesting, drug delivery. most fabrication techniques, use microorganisms, do not precise NP size control require separation microorganisms produced quicker at producing than bottom-up methods. drawbacks include need find required processing parameters, requires extensive experimentation, complex non-linear relationships between inputs outputs (e.g., size).

Language: Английский

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Role of nanoparticles in enhancing chemotherapy efficacy for cancer treatment

Next Materials, Journal Year: 2024, Volume and Issue: 2, P. 100128 - 100128

Published: Jan. 1, 2024

This article is an overview of the current state nanoparticles because their emerging usage in cancer treatment, covering that have been authorized for use therapy currently undergoing clinical testing. Recent advances nanoparticle engineering, coupled with enhanced understanding critical attributes (size, shape, and surface properties) conjunction biological systems, present novel prospects therapeutic development. Although inorganic metallic are gaining recognition studies due to potential usefulness but nanomaterials primarily polymeric, liposomal, nano crystal based dominate therapy. Polymeric (NPs) contain specific ligands, such as polyglycolic acid (PGA) polylactic (PLA), which a chemical affinity malignant cells target tumors. Nanocrystals stand out high loading efficiency, stability, extended drug release, capacity deliver poorly soluble medications. The limitations conventional chemotherapy overcome variety applications improved care by metal-based nanoparticles, either used alone or combination. dynamic nature nanotechnology drives continued developments like protein-based micelles. Polymer lipid encapsulation within nanocrystals becoming more popular, suggesting long-term trend. advancement marks significant breakthrough life-saving nanotechnology, particularly sets stage pioneering nanomedicine.

Language: Английский

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Transition Metal Nitrides Are Heating Up the Field of Plasmonics

Chemistry of Materials, Journal Year: 2022, Volume and Issue: 34(10), P. 4249 - 4258

Published: May 2, 2022

Metal nitride nanostructures have been predicted to exhibit plasmonic responses in the UV IR region, which can enable their potential use as low-cost, chemically, and thermally stable materials several applications. In case of photothermal applications, nitrides shown, both numerically experimentally, perform better than noble metals. Additionally superior thermal stability metal offers compatibility with high temperature device fabrication techniques. The plasmon frequency for transition be tuned from region by varying type metal/nitrogen ratio. Recently, studies focused on developing applying free-standing nanostructures. Most investigations TiN, but late focus has shifting investigate other nanostructured such ZrN HfN. This Perspective will highlight recent key findings synthesis nitrides; associated properties; application therapy, solar-driven water evaporation, chemical reactions. An outlook current knowledge gaps challenges future directions further this field is also presented.

Language: Английский

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Photothermal Therapy with HER2-Targeted Silver Nanoparticles Leading to Cancer Remission

Pharmaceutics, Journal Year: 2022, Volume and Issue: 14(5), P. 1013 - 1013

Published: May 8, 2022

Nanoparticles exhibiting the localized surface plasmon resonance (LSPR) phenomenon are promising tools for diagnostics and cancer treatment. Among widely used metal nanoparticles, silver nanoparticles (Ag NPs) possess strongest light scattering strength. However, therapeutic potential of Ag NPs has until now been underestimated. Here we show targeted photothermal therapy solid tumors with 35 nm HER2-targeted NPs, which were produced by green synthesis using an aqueous extract Lavandula angustifolia Mill. Light irradiation tests demonstrated effective hyperthermic properties these namely heating 10 °C in min. To mediate therapy, conjugated to scaffold polypeptide, affibody ZHER2:342, recognizes a clinically relevant oncomarker HER2. The conjugation was mediated PEG linker obtain Ag-PEG-HER2 nanoparticles. Flow cytometry showed that particles successfully bind HER2-overexpressing cells specificity comparable full-size anti-HER2 IgGs. A confocal microscopy study efficient internalization into less than 2 h incubation. Cytotoxicity assays cell death upon exposure irradiation, caused production reactive oxygen species. Xenograft tumor vivo resulted full primary regression prevention metastatic spread. Thus, first time, have shown HER2-directed plasmonic sensitizers oncotherapy.

Language: Английский

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Genetically encoded BRET-activated photodynamic therapy for the treatment of deep-seated tumors

Light Science & Applications, Journal Year: 2022, Volume and Issue: 11(1)

Published: Feb. 21, 2022

Abstract Photodynamic therapy (PDT) is one of the most appealing photonic modalities for cancer treatment based on anticancer activity light-induced photosensitizer-mediated reactive oxygen species (ROS), but a limited depth light penetration into tissues does not make possible deep-seated neoplasms and thus complicates its widespread clinical adoption. Here, we introduce concept genetically encoded bioluminescence resonance energy transfer (BRET)-activated PDT, which combines an internal source photosensitizer (PS) in single-genetic construct, can be delivered to tumors seated at virtually unlimited then triggered by injection substrate initiate their treatment. To illustrate concept, engineered genetic NanoLuc-miniSOG BRET pair, combining NanoLuc luciferase flashlight phototoxic flavoprotein miniSOG, generates ROS under luciferase-substrate injection. We prove feasibility mice bearing expressing tumor, followed elimination administration. Then, demonstrate targeted delivery gene, via tumor-specific lentiviral particles, successful elimination, with tumor-growth inhibition (TGI) coefficient exceeding 67%, confirms great therapeutic potential proposed concept. In conclusion, this study provides proof-of-concept deep-tissue “photodynamic” without external that considered as alternative traditional PDT.

Language: Английский

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A comprehensive review on the synthesis and photothermal cancer therapy of titanium nitride nanostructures

Inorganic and Nano-Metal Chemistry, Journal Year: 2022, Volume and Issue: 53(4), P. 366 - 387

Published: April 27, 2022

STitanium nitride, a substitute plasmonic material to gold with exceptional features is favorable photo-absorbing agent for photothermal therapy (PTT) based on the spectral match of their plasmon resonance band and biological transparency window as well good biocompatibility. Nevertheless, review its synthesis possible utilization in cancer has never been explored. This presents synthetic routes titanium nitrides (TiN) nanoparticles (NPs) performance therapy. The techniques that were looked into are solvothermal, hydrothermal, sol-gel, laser ablation, chemical vapor deposition non-thermal plasma techniques. study established extraordinary prospect TiN NPs treatment via

Language: Английский

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Nanoscale metal–organic frameworks for tumor phototherapy

Journal of Materials Chemistry B, Journal Year: 2021, Volume and Issue: 9(18), P. 3756 - 3777

Published: Jan. 1, 2021

Metal-Organic Frameworks (MOFs) are constructed from metal ions/cluster nodes and functional organic ligands through coordination bonds. Owing to the advantages of diverse synthetic methods, easy modification after synthesis, large adsorption capacity for heavy metals, short equilibrium time, considerable attention has recently been paid MOFs tumor phototherapy. Through rational tuning ions ligands, present abundant properties various applications. Light-triggered phototherapy, including photodynamic therapy (PDT) photothermal (PTT), is an emerging cancer treatment approach. Nanosized can be applied as phototherapeutic agents accomplish phototherapy with excellent efficacy. This review outlines latest advances in field ion-based MOFs.

Language: Английский

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Artificial Scaffold PolypeptidesAs an Efficient Tool for the Targeted Delivery of Nanostructures In Vitro and In Vivo

Acta Naturae, Journal Year: 2022, Volume and Issue: 14(1), P. 54 - 72

Published: May 10, 2022

The use of traditional tools for the targeted delivery nanostructures, such as antibodies, transferrin, lectins, or aptamers, often leads to an entire range undesirable effects. large size antibodies does not allow one reach required number molecules on surface nanostructures during modification, and constant domains heavy chains, due their effector functions, can induce phagocytosis. In recent two decades, polypeptide scaffold a non-immunoglobulin nature, antibody mimetics, have emerged much more effective targeting tools. They are small in (320 kDa), possess high affinity (from subnano- femtomolar binding constants), low immunogenicity, exceptional thermodynamic stability. These be effectively produced bacterial cells, and, using genetic engineering manipulations, it is possible create multispecific fusion proteins nanoparticles cells with given molecular portrait, which makes polypeptides optimal tool theranostics.

Language: Английский

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Laser-ablative aqueous synthesis and characterization of elemental boron nanoparticles for biomedical applications

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: June 1, 2022

Abstract Boron-based nano-formulations look very promising for biomedical applications, including photo- and boron neutron capture therapies, but the fabrication of non-toxic water-dispersible nanoparticles (NPs), which contain highest atom concentration, is difficult using currently available chemical plasma synthesis methods. Here, we demonstrate purely aqueous clean NPs by methods femtosecond laser ablation from a solid target in water, thus free any toxic organic solvents, characterize their properties. We show that despite highly oxidizing water ambience, laser-ablative process follows an unusual scenario leading to formation together with boric acid (H 3 BO ) as oxidation by-product coating nanoparticles, acts stabilize elemental dispersion. then purification residual deionized followed polyethylene glycol improve colloidal stability biocompatibility. It was found formed have spherical shape averaged size about 37 nm, are composed mostly amorphous phase presence certain crystalline fraction. The synthesized low toxicity exhibit strong absorption NIR window relative tissue transparency, use photoacoustic imaging phototherapy, addition promise therapy. This combined potential ability generating therapy functionalities makes laser-synthesized B multifunctional agent applications.

Language: Английский

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