Schottky engineering of GDYO@Pt to boost piezoelectric and oxidative stress modulation for accelerated cranial regeneration
Abstract
Piezoelectric
stimulation
regulates
cellular
metabolism
and
enhances
bone
repair.
However,
the
overproduction
of
reactive
oxygen
species
(ROS)
hypoxia-induced
oxidative
stress
reduce
efficacy
electrical
hinder
regeneration.
To
address
these
challenges,
a
platinum-decorated
graphdiyne
oxide
(GDYO@Pt)
multifunctional
piezoelectric
semiconductor
was
engineered
for
first
time
to
eliminate
ROS
self-supply
while
enabling
stimulation.
In
this
system,
interface
dipole
drives
built-in
electric
field,
triggering
charge
redistribution
in
GDYO
breaking
symmetry
amplify
piezoelectricity.
Ultrasound-triggered
polarized
charges
at
Schottky
junction
lower
barrier
promote
GDYO→Pt
electron
transfer
hydrogen
production,
where
generated
H₂
neutralizes
cytotoxic
•OH
radicals,
holes/nanozyme-driven
H₂O₂→O₂
conversion,
synergistically
alleviating
stress.
vitro
vivo
studies
demonstrate
that
ultrasound-activated
GDYO@Pt
accelerates
cranial
defect
repair
via
osteogenesis,
angiogenesis,
immunomodulation.
This
work
establishes
inaugural
paradigm
piezoelectric-catalytic
synergy
regeneration,
heterointerface
uniquely
integrates
energy
conversion
with
biological
regulation
through
its
precisely
asymmetric
structure.
Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown
Published: April 30, 2025
Language: Английский