Journal of Biomedical Materials Research Part A,
Journal Year:
2024,
Volume and Issue:
112(12), P. 2187 - 2201
Published: July 4, 2024
Abstract
Corneal
blindness
affects
over
10
million
patients
worldwide.
Due
to
the
limited
supply
of
donor
corneas
and
frequent
graft
failure,
bioengineered
alternatives
are
crucial.
To
overcome
drawbacks
associated
with
corneal
substitutes
from
synthetic
biomaterials,
fabrication
plant‐derived
biomaterials
is
a
potential
alternative.
Herein,
soy
protein
glutenin
in
combination
different
crosslinkers
were
evaluated
for
substitutes.
Optical,
mechanical,
biochemical
properties
fabricated
constructs
control
rabbit
vitro
.
Soy
crosslinked
peroxidase/H
2
0
possessed
transparency
mechanical
comparable
controls,
although
their
water
content
biocompatibility
inferior.
In
contrast,
tannic
acid
showed
similar
content,
tensile
strength,
as
corneas;
however,
these
displayed
significantly
lower
higher
strain
failure.
Finally,
cross‐linked
using
formaldehyde
excellent
transparency,
biocompatibility,
however;
they
exhibited
strength
than
controls.
This
study
first
establish
CIELAB
color
values
cornea,
allowing
quantitative
optical
evaluation
tissue‐engineered
Thus,
crosslinking
strategy
utilizing
proteins
promising
direction
development
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Feb. 3, 2025
Zinc
deficiency
precipitates
considerable
health
problems
in
developing
countries,
affecting
development,
growth,
and
immunological
function.
The
main
issue
is
that
zinc
exhibits
limited
bioavailability
diets,
sometimes
compounded
by
the
high
concentration
of
phytate
molecules
staple
foods,
which
impedes
absorption.
Nanoparticles
offer
a
promising
approach
to
improve
address
through
application
advanced
agricultural
techniques.
study
introduces
novel
method
for
synthesizing
oxide
(ZnO)
biometallic
nanoparticles
employing
aqueous
extracts
Salvia
hispanica
L.
(Chia
seed)
as
reducing
capping
agent
an
environmentally
sustainable
way.
Their
active
phytoconstituents
acted
stabilising
facilitated
conversion
ionic
(Zn2+)
into
elemental
zinc.
synthesized
diverse
forms
(NP-α,
NP-β,
NP-γ,
NP-δ,
NP-ε,
NP-η)
utilising
various
molar
concentrations
(0.5mM,
1.0mM,
3.0mM,
5.0mM,
7.0mM,
9.0mM)
precursor
solution,
nitrate
[(ZnNO3)2].
NPs
were
evaluated
using
UV-Vis
spectroscopy,
FTIR
XRD,
SEM,
EDX,
TEM,
SAED,
HR-TEM
methods
determine
their
characteristics.
standard
particle
size
varies
from
40
80
nm,
exhibiting
consistent
hexagonal
morphology
polydispersed
characteristic
with
minimal
fluctuation.
molarity
substantially
influenced
shape
NPs,
particularly
concerning
surface
area.
An
vitro
evaluation
was
performed
investigate
antibacterial
activity
against
Staphylococcus
aureus
possible
degradation
hazardous
dye
Congo
red.
particles
exhibited
efficacy
at
ppm
ZnO,
antidiabetic
qualities
10
µl/ml
ZnONPs,
antioxidant
ranging
100
900
showing
89.47
±
0.022
µg
AAE/mg,
maximum
total
capacity
(TAC),
potential
50
mg
revealed
50.78%
CR
after
90
min
irradiation.
Additionally,
it
had
significant
inhibitory
effects
on
enzymes
α-amylase
(72.93%)
α-glucosidase
(60.48%)
ZnONP-η.
seems
enhance
increased
sizes
reduced
specific
areas.
antioxidant,
antidiabetic,
catalytic
capabilities
improved
increase
size.
Nevertheless,
found
corresponded
substantial
reduction
activity.
presents
efficient
eco-friendly
synthesis
highlighting
many
biological
applications.
International Journal of Polymeric Materials,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 21
Published: April 8, 2024
Electrospinning
nanofiber
technology
has
emerged
as
a
promising
paradigm
with
diverse
biomedical
applications.
Various
electrospinning
techniques
are
employed
to
produce
wide
range
of
nanofibers
using
both
natural
and
synthetic
materials
precursors.
The
biodegradation
biocompatibility
these
offer
numerous
opportunities
for
versatile
pharmaceutical
Surface
functionalization
modification
further
enhance
the
scope
therapeutic
uses.
Electrospun
exhibit
multifaceted
applications,
including
wound
healing,
tissue
regeneration,
drug
delivery,
antimicrobial
activity.
In
addition
conventional
show
potential
theranostic
encompassing
biosensing,
bioimaging,
diagnostic
purposes
detection
various
disease
conditions.
This
comprehensive
literature
explores
its
highlighting
opportunities,
challenges,
future
perspectives
in
this
field.
International Journal of Biological Macromolecules,
Journal Year:
2024,
Volume and Issue:
269, P. 132071 - 132071
Published: May 4, 2024
Wound
healing
is
a
challenging
clinical
problem
and
efficient
wound
management
essential
to
prevent
infection.
This
best
done
by
utilizing
biocompatible
materials
in
order
complete
the
rapid
manner,
with
functional
esthetic
outcomes.
In
this
context,
zein
protein
fulfills
criteria
of
ideal
dressing
which
include
non-toxicity
non-inflammatory
stimulation.
Zein
gels
containing
rutin
were
prepared
without
any
chemical
refinement
or
addition
gelling
agents
obtain
natural
formulation
characterized
antioxidant
anti-inflammatory
properties
be
proposed
for
treatment
burns
sores.
vitro
scratch
assay
showed
that
gel
formulations
promoted
cell
migration
gap
closure
within
24
h
(~90
%).
addition,
vivo
activities
rutin-loaded
greater
therapeutic
efficacy
Wistar
rats,
decrease
area
about
90
%
at
day
10
respect
free
form
bioactive
DuoDERM®.
The
evaluation
various
markers
(TNF-α,
IL-1β,
IL-6,
IL-10)
confirmed
effect
formulation.
results
illustrate
feasibility
exploiting
peculiar
features
wound-healing
purposes.
