Exploring the intersection of biology and design for product innovations DOI Creative Commons
Ajay P. Malshe, Salil Bapat,

K. P. Rajurkar

et al.

CIRP Annals, Journal Year: 2023, Volume and Issue: 72(2), P. 569 - 592

Published: Jan. 1, 2023

Design, development, productization, and applications of advanced product concepts are pressing for higher multifunctionality, resilience, maximization available resources equitably to meet the growing continuing demands global customers. These have further accelerated during recent COVID-19 pandemic be a challenge. Engineering designs one most effective ways endow products with functions, sustainability. Biology, through millions years evolution, has met these acute requirements under severe resource environmental constraints. As manufacturing is reaching fundamental limits raw materials, labor, constraints in terms availability, accessibility, affordability, new approaches call action challenges. Understanding biology an attractive, novel, desired frontier learning implementation this action. This focus paper discussed examples convergence engineering design lessons learned applied from biology.

Language: Английский

Biomimetic Natural Biopolymer‐Based Wet‐Tissue Adhesive for Tough Adhesion, Seamless Sealed, Emergency/Nonpressing Hemostasis, and Promoted Wound Healing DOI
Wen Yang, Xinyi Kang, Xu Gao

et al.

Advanced Functional Materials, Journal Year: 2022, Volume and Issue: 33(6)

Published: Dec. 3, 2022

Abstract Bioadhesives have been used in clinics among the most prospective alternatives to sutures and staples for wound sealing repairing; however, they generally inadequate adhesion wet surfaces, improper mechanical strength, poor hemostasis, cytotoxicity. To address these challenges, a robust tissue adhesive based on collagen starch materials (CoSt) is designed this study. CoSt hydrogels integrate feature of drainage, molecular penetration strengthen cross‐linking similar mussel, ivy, oyster glues, which remove interfacial water quickly, reinforce tough dissipation involve multiple reversible dynamic interactions. Therefore, form strong sutureless injured tissues, accompanying actuate biointerfaces direct contact with liquids or blood, resolving crucial impediments commercially accessible adhesives. The novel bioadhesive shows repeatable adhesiveness (62 ± 4.8 KPa), high performance (153.2 35.1 mmHg), fast self‐healing ability, excellent injectability, shape adaptability. For different hemostatic needs rat models tail amputation, skin incision, severe liver, abdominal aorta, transected nerve injuries, hydrogel better efficiency than fibrin glue because coordinate efficacy property, outstanding red blood cell arresting capability, activation barrier membrane. Moreover, vivo investigation injury repair model validate that accelerate healing functional recovery via damage/defects. Tough adhesion, quick distinguished biocompatibility, suitability match irregular‐shaped target sites, good promotion makes it various biomedical applications.

Language: Английский

Citations

120
Recent Advances in Mucoadhesive Interface Materials, Mucoadhesion Characterization, and Technologies DOI
Ilker S. Bayer

Advanced Materials Interfaces, Journal Year: 2022, Volume and Issue: 9(18)

Published: May 23, 2022

Abstract Mucoadhesion is an extremely important field of adhesion science and the comprehensive understanding modulation mucoadhesion can lead to lifesaving materials technologies. For instance, deadly cases COVID‐19 (SARS‐CoV‐2) cytokine storm are associated with viral overproduction mucus, which obstructs airways. Mucin key polymeric compound that known as a family high molecular weight, heavily glycosylated proteins in epithelial tissues. occur many different ways such receptor specific charge interactions, covalent or noncovalent bonds. New mucin‐mimic polymers replicate its beneficial traits prevent biofilm formation biofouling not only biotechnology but also membrane This review addresses latest understandings related mucin's role wet considering physiological conditions shows how this translates into interfacial polymer adhesion. Advances measurement techniques including rheological aspects polymer–mucin adhesive interactions presented. Specific mucoadhesive systems discussed hydrogel mucoadhesion, catechol/dopamine functionalization, nanoparticles. overview may expand current between soft contributes elastocapillary phenomena design applications new membranes, drugs, pharmaceutical devices, lubricated surfaces.

Language: Английский

Citations

88
Preparation of Strong and Thermally Conductive, Spider Silk-Inspired, Soybean Protein-Based Adhesive for Thermally Conductive Wood-Based Composites DOI
Xin Zhang,

Chun Long,

Xiaobo Zhu

et al.

ACS Nano, Journal Year: 2023, Volume and Issue: 17(19), P. 18850 - 18863

Published: Oct. 2, 2023

The development of formaldehyde-free functional wood composite materials through the preparation strong and multifunctional soybean protein adhesives to replace formaldehyde-based resins is an important research area. However, ensuring bonding performance adhesive while simultaneously developing thermally conductive its corresponding composites challenging. Taking inspiration from microphase separation structure spider silk, boron nitride (BN) soy isolate (SPI) were mixed by ball milling obtain a BN@SPI matrix combined with self-synthesized hyperbranched reactive substrates as amorphous region reinforcer cross-linker triglycidylamine prepare cross-linked structure. These findings indicate that mechanical can be employed strip BN followed combination SPI, resulting in tight bonded interface connection. Subsequently, adhesive's dry wet shear strengths increased 14.3% 90.5% 1.83 1.05 MPa, respectively. resultant also possesses good thermal conductivity (0.363 W/mK). Impressively, because hot-pressing helps establish conduction pathway, wood-based 10 times higher than SPI adhesive, which shows similar ceramic tile has excellent potential for biothermal materials, geothermal floors, energy storage materials. Moreover, possessed effective flame retardancy (limit oxygen index = 36.5%) mildew resistance (>50 days). This bionic design represents efficient technique biomass composites.

Language: Английский

Citations

48
Biomimetic design strategies for biomedical applications DOI Creative Commons
Xinwei Wei, Yanfang Wang, Yun Liu

et al.

Matter, Journal Year: 2024, Volume and Issue: 7(3), P. 826 - 854

Published: Jan. 22, 2024

Language: Английский

Citations

34
Multifunctional naturally derived bioadhesives: From strategic molecular design toward advanced biomedical applications DOI Creative Commons

Mahshid Kharaziha,

Thomas Scheibel, Sahar Salehi

et al.

Progress in Polymer Science, Journal Year: 2024, Volume and Issue: 150, P. 101792 - 101792

Published: Jan. 26, 2024

In the last decades, adhesives derived from natural resources (i.e., bioadhesives) have emerged as promising alternative to standard wound closure devices, including sutures, clips, and strips, owing relatively easy rapid application, minimal tissue damage, fast hemostasis, ability decrease risk of infection. Various synthetic materials been utilized bioadhesives. These find extensive application in various biomedical fields, ranging simple sealing controlled drug delivery, regeneration, noninvasive therapy. Considering weak underwater adhesion, degradability, biological performances adhesives, naturally derived-based are more attractive. The first generation these bioadhesives provided primarily only one function. Moreover, they had issues long curing time, slow high degradation rate, low mechanical properties, transferring contamination wound. chemically genetically engineered strategies applied advance their multifunctionality. synergy bonding chemistry, topography, mechanics dissipation structure supports improved adhesion rate. developed that cover subjects innovative biomaterial synthesis or functionalization cutting-edge manufacturing processes. However, fulfill all criteria an ideal bioadhesive for clinical applications, efforts should be devoted investigating surface characteristics target tissues long-term relationship between physiochemical properties polymers cohesion mechanisms, well adhesive functionality. This review outlines recent progress on naturally-derived bioadhesives, proteins polysaccharides, focusing designing approaches based engineering strategies, development, applications. Furthermore, challenges current studies summarized show future perspectives developing bioengineered high-performance use.

Language: Английский

Citations

29
Recent advances in biomimetic hemostatic materials DOI Creative Commons

Simin Jiao,

Xi Zhang,

Hang Cai

et al.

Materials Today Bio, Journal Year: 2023, Volume and Issue: 19, P. 100592 - 100592

Published: Feb. 24, 2023

Although the past decade has witnessed unprecedented medical advances, achieving rapid and effective hemostasis remains challenging. Uncontrolled bleeding wound infections continue to plague healthcare providers, increasing risk of death. Various types hemostatic materials are nowadays used during clinical practice but have many limitations, including poor biocompatibility, toxicity biodegradability. Recently, there been a burgeoning interest in organisms that stick objects or produce sticky substances. Indeed, applying biological adhesion properties an interesting approach. This paper reviews behavior, bionics, mechanisms related hemostasis. Furthermore, this covers benefits, challenges prospects biomimetic materials.

Language: Английский

Citations

31
Natural Regenerative Hydrogels for Wound Healing DOI Creative Commons
Mariana Chelu,

José María Calderón Moreno,

Adina Magdalena Musuc

et al.

Gels, Journal Year: 2024, Volume and Issue: 10(9), P. 547 - 547

Published: Aug. 23, 2024

Regenerative hydrogels from natural polymers have come forth as auspicious materials for use in regenerative medicine, with interest attributed to their intrinsic biodegradability, biocompatibility, and ability reassemble the extracellular matrix. This review covers latest advances used wound healing, focusing on chemical composition, cross-linking mechanisms, functional properties. Key carbohydrate polymers, including alginate, chitosan, hyaluronic acid, polysaccharide gums, agarose, carrageenan, xanthan gum, are discussed terms of sources, structures specific properties suitable applications. The further explores categorization based ionic charge, response physiological stimuli (i.e., pH, temperature) particularized roles tissue self-healing. Various methods enhance mechanical biological performance these also examined. By highlighting recent innovations ongoing challenges, this article intends give a detailed understanding potential revolutionize medicine improve patient healing outcomes.

Language: Английский

Citations

17
A mussel inspired polyvinyl alcohol/collagen/tannic acid bioadhesive for wet adhesion and hemostasis DOI
Ying Liu, Chenyu Zhao,

Changtong Song

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 235, P. 113766 - 113766

Published: Jan. 23, 2024

Language: Английский

Citations

10
Harnessing Biomimicry for Controlled Adhesion on Material Surfaces DOI Creative Commons
Weijun Li,

Ruini Zhou,

Yirui Ouyang

et al.

Small, Journal Year: 2024, Volume and Issue: 20(45)

Published: July 19, 2024

Abstract Nature serves as an abundant wellspring of inspiration for crafting innovative adhesive materials. Extensive research is conducted on various complex forms biological attachment, such geckos, tree frogs, octopuses, and mussels. However, significant obstacles still exist in developing materials that truly replicate the behaviors functionalities observed living organisms. Here, overview organs, structures, secretions endowed with adhesion capabilities, delving into intricate relationship between their morphology function, potential biomimicry are provided. First, design principles mechanisms behavior individual organ nature summarized from perspective structural size constraints. Subsequently, value engineered bioinspired through selective application cases practical fields emphasized. Then, a forward‐looking gaze conceivable challenges associated opportunities harnessing biomimetic strategies advancing material innovation highlighted cast.

Language: Английский

Citations

9
A comprehensive review on multifunctional adhesives/bio adhesives and its applications DOI
Nisha Kumari, Vatsala Chaturvedi, Sumit Mishra

et al.

International Journal of Adhesion and Adhesives, Journal Year: 2025, Volume and Issue: unknown, P. 103987 - 103987

Published: Feb. 1, 2025

Language: Английский

Citations

1