BOX-BEHNKEN OPTIMIZATION OF MELOXICAM MICROCAPSULE SCAFFOLDS FOR PRECISION DRUG DELIVERY IN ARTHRITIS: ENHANCED STABILITY, EFFECTIVE STERILIZATION, AND IN VIVO THERAPEUTIC POTENTIAL

International Journal of Applied Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 410 - 425

Published: Jan. 7, 2025

Objective: This study aims to develop and evaluate an innovative implantable drug delivery system using gelatin microspheres loaded with Nonsteroidal Anti-Inflammatory Drugs (NSAIDs), namely meloxicam (MXM), integrated into a scaffold. is designed enhance efficiency sustain release. Methods: MXM-loaded 1:1 ratio of Poly Lactic Acid (PLA) Lacto Glycolic (PLGA) were optimized for size, yield, efficiency, Gelatin scaffolds as rod-shaped implants, tested stability degradation in pH 7.4 4.0 buffers at 37 °C 100 d, sterilized γ-radiation. Implants evaluated rabbits, blood samples analyzed via High-Performance Liquid Chromatography (HPLC) pharmacokinetic parameters statistically (P<0.05). Results: The PLA PLGA demonstrated favorable characteristics such smaller particle sizes, high efficient entrapment Optimization Design Expert resulted highly desirable scaffolds, evidenced by desirability factor close one across all assessed variables. exhibited robust physicochemical properties, including sustained release over extended period, highlighting their potential diverse biomedical applications. showed greater buffer solutions contrast higher mass loss acidic environments (14.4% vs. 9.66%). γ-Radiation sterilization effectively prevented microbial contamination. In vivo studies confirmed MXM detection plasma, Scaffold-MXM (iS-MMS-17) (optimized scaffold) showing mean Cmax values significant Area Under Curve (AUC) parameters, suggesting its effective therapy. Conclusion: found that the strong properties release, making them suitable use. more stable than 4.0, γ-radiation detection, iS-MMS-17 promising pain arthritis

Language: Английский

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Functional Hydrogel Interfaces for Cartilage and Bone Regeneration

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Abstract Effective treatment of bone diseases is quite tricky due to the unique nature tissue and complexity repair process. In combination with biological materials, cells factors can provide a highly effective safe strategy for regeneration, especially based on these multifunctional hydrogel interface materials. However, itis still challenge formulate materials fascinating properties (e.g., activity, controllable biodegradability, mechanical strength, excellent cell/tissue adhesion, release properties) their clinical applications in complex processes. this review, we will highlight recent advances developing functional hydrogels. We then discuss barriers producing without sacrificing inherent properties, potential cartilage are discussed. Multifunctional serve as fundamental building block engineering.

Language: Английский

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Preparation of agarose microspheres with large pore size and high load and purification of antibody in serum based on microfluidic technology

Colloid & Polymer Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Language: Английский

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Baicalein-loaded porous silk fibroin microspheres modulate the senescence of nucleus pulposus cells through the NF-κB signaling pathway

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114537 - 114537

Published: Jan. 1, 2025

Language: Английский

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Sol-Gel/Microemulsion Synthesis of Mesoporous Bioactive Glass Microsphere Using Acetate Precursors: Characterization and Drug Delivery Potential

Materials Chemistry and Physics, Journal Year: 2025, Volume and Issue: unknown, P. 130477 - 130477

Published: Jan. 1, 2025

Language: Английский

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