Perilous paradigm of graphene oxide and its derivatives in biomedical applications: Insight to immunocompatibility

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 176, P. 116842 - 116842

Published: May 28, 2024

With advancements in nanotechnology and innovative materials, Graphene Oxide nanoparticles (GONP) have attracted lots of attention among the diverse types nanomaterials owing to their distinctive physicochemical characteristics. However, usage at scientific industrial level has also raised concern toxicological interaction with biological system. Understanding these interactions is crucial for developing guidelines recommendations applications GONP various sectors, like biomedicine environmental technologies. This review offers insights an in-depth analysis processes associated immunotoxicity multiple cell lines including human whole blood cultures, dendritic cells, macrophages, cancer lines. The complicated between graphene oxide immune system, are highlighted this work, which reveals a range immunotoxic consequences inflammation, immunosuppression, immunostimulation, hypersensitivity, autoimmunity, cellular malfunction. Moreover, effects respect vivo models mice zebrafish, insighting GO Nanoparticles' cytotoxicity. study provides invaluable researchers, policymakers, industrialist understand exploit beneficial controlled measure health environment.

Language: Английский

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Nano/microplastics in indoor air: A critical review of synthesis routes for toxicity testing and preventative measure strategies

Process Safety and Environmental Protection, Journal Year: 2023, Volume and Issue: 180, P. 274 - 304

Published: Oct. 4, 2023

A future without plastic is difficult to imagine. Plastics are ubiquitous in every aspect of our lives, including cosmetics, clothing, packaging, toys, furniture, pigments, and carpets. Microplastic pollution the oceans has had deadly consequences worldwide. However, few realize that micro-nanoplastics (MnPs) also a significant contributor airborne pollution. Indoor air can be up 100 times higher than outdoor Every day, we inhale 130 small particulates, concentration MnPs all environments steadily rising. Several studies have investigated presence aquatic environments, but focused on indoor MnPs. This study aims investigate origins, movement patterns, repercussions Additionally, it seeks understand mechanisms through which infiltrate living organisms impact their various body parts, potentially resulting multiple diseases health risks. Here, discuss synthesis micro-nanoplastic routes different polymers prepare nanoplastics for examination toxicological effects by vivo vitro testing. We propose unique remediation method control MnP particles using DTA (detect, trap, adsorb) technology. outlined variety effective materials trap adsorb nanoplastics. recommend fabricating filters electrospinning devices employing these efficient create multifunctional use commercial purifiers. encourage researchers open new paths this research air. In research, environmental suitability achieved adoption biodegradable fibers considering nanobiomaterials. potential release addressing issue material detachment from endeavors.

Language: Английский

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Biofilm modifiers: The disparity in paradigm of oral biofilm ecosystem

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 164, P. 114966 - 114966

Published: June 1, 2023

A biofilm is a population of sessile microorganisms that has distinct organized structure and characteristics like channels projections. Good oral hygiene reduction in the prevalence periodontal diseases arise from minimal accumulation mouth, however, studies focusing on modifying ecology biofilms have not yet been consistently effective. The self-produced matrix extracellular polymeric substances greater antibiotic resistance make it difficult to target eliminate infections, which lead serious clinical consequences are often lethal. Therefore, better understanding required modify order eradicate infection, only instances disorders but also terms nosocomial infections. review focuses several modifiers prevent as well involvement resistance, implants or in-dwelling device contamination, dental caries, other disorders. It discusses recent advances nanotechnology may novel strategies for preventing treating infections caused by outlook infection control.

Language: Английский

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Biosynthesis of copper nanoparticles using Solenostemma argel and their effect on enhancing salt tolerance in barley plants

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: June 3, 2024

The distinctive characteristics of nanoparticles and their potential applications have been given considerable attention by scientists across different fields, particularly agriculture. However, there has limited effort to assess the impact copper (CuNPs) in modulating physiological biochemical processes response salt-induced stress. This study aimed synthesize CuNPs biologically using Solenostemma argel extract determine effects on morphophysiological parameters antioxidant defense system barley (Hordeum vulgare) under salt biosynthesized were characterized (UV-vis spectroscopy with Surface Plasmon Resonance at 320 nm, crystalline nature formed NPs was verified via XRD, FTIR recorded presence functional groups, while TEM confirmed shape (spherical) sizes (9 18 nm) CuNPs. Seeds plants grown plastic pots exposed levels (0, 100 200 mM NaCl). Our findings revealed that supplementation 25 50 mg/L) salinized significantly mitigate negative impacts stress enhanced plant growth-related parameters. High salinity level oxidative damage raising concentrations osmolytes (soluble protein, soluble sugar, proline), malondialdehyde (MDA) hydrogen peroxide (H2O2). In addition, increasing activities enzymatic antioxidants, total phenol, flavonoids. Interestingly, exposing salt-stressed plant-growth characteristics, photosynthetic pigments, gas exchange Furthermore, counteracted lowering accumulation osmolytes, H2O2, MDA, flavonoids, simultaneously enhancing enzymes. conclusion, application presents a promising approach sustainable strategy enhance resistance stress, surpassing conventional methods terms environmental balance.

Language: Английский

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Biophysical translational paradigm of polymeric nanoparticle: Embarked advancement to brain tumor therapy

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 179, P. 117372 - 117372

Published: Aug. 28, 2024

Polymeric nanoparticles have emerged as promising contenders for addressing the intricate challenges encountered in brain tumor therapy due to their distinctive attributes, including adjustable size, biocompatibility, and controlled drug release kinetics. This review comprehensively delves into latest developments synthesizing, characterizing, applying polymeric explicitly tailored therapy. Various synthesis methodologies, such emulsion polymerization, nanoprecipitation, template-assisted fabrication, are scrutinized within context of targeting, elucidating advantages limitations concerning traversing blood-brain barrier. Furthermore, strategies pertaining surface modification functionalization expounded upon augment stability, targeting prowess amidst milieu microenvironment. Characterization techniques encompassing dynamic light scattering, transmission electron microscopy, spectroscopic methods evaluate physicochemical attributes engineered Moreover, a comprehensive exploration manifold applications delivery, gene therapy, imaging, combination therapies tumours is undertaken. Special emphasis placed on encapsulation diverse therapeutics nanoparticles, thereby shielding them from degradation enabling precise brain. Additionally, recent advancements stimuli-responsive multifunctional probed potential personalized medicine theranostics tumours. In essence, this furnishes an all-encompassing overview strides made tailoring illuminating synthesis, characterization, multifaceted application.

Language: Английский

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Nanoscale Morphologies on the Surface of 3D-Printed Titanium Implants for Improved Osseointegration: A Systematic Review of the Literature

International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 4171 - 4191

Published: July 1, 2023

Abstract: Three-dimensional (3D) printing is serving as the most promising approach to fabricate personalized titanium (Ti) implants for precise treatment of complex bone defects. However, bio-inert nature Ti material limits its capability rapid osseointegration and thus influences implant lifetime in vivo. Despite macroscale porosity promoting osseointegration, 3D-printed surface morphologies at nanoscale have gained considerable attention their potential improve specific outcomes. To evaluate influence on outcomes discuss available strategies, we systematically searched evidence according PRISMA PubMed, Embase, Web Science, Cochrane (until June 2022). The inclusion criteria were vivo (animal) studies reporting implants. risk bias (RoB) was assessed using Systematic Review Centre Laboratory Animal Experimentation (SYRCLE's) tool. quality evaluated Research: Reporting In Vivo Experiments (ARRIVE) guidelines. (PROSPERO: CRD42022334222). Out 119 retrieved articles, 9 met criteria. suggests that irregular nano-texture, nanodots nanotubes with a diameter 40– 105nm porous/solid result better vertical ingrowth compared untreated/polished ones by significantly cell adhesion, matrix mineralization, osteogenic differentiation through increasing integrin expression. RoB low 41.1% items, unclear 53.3%, high 5.6%. achieved mean score 17.67. Our study demonstrates nanostructures controlled properties osseointegration. given small number studies, variability experimental designs, lack across results should be interpreted caution. Keywords: nano-pattern, 3D-printed, implant, modification,

Language: Английский

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In silico nanotoxicology: The computational biology state of art for nanomaterial safety assessments

Materials & Design, Journal Year: 2023, Volume and Issue: 235, P. 112452 - 112452

Published: Nov. 1, 2023

In recent decade, nanotechnology has got an extensive advancement in terms of production and application nanomaterials. With the advancement, concern risen for their biomedical ecological safety, provoking a detailed analysis safety assement. Numerous experimental computational approach been developed to accomplish goal assessment nanomaterials leading orgin interdisciplinary fields like nanoinformatics. Nanoinformatics accomplished significant strides with development several modeling frameworks, data platforms, knowledge infrastructures, silico tools risk forecasts This review is attemption decipher establish bridge between two emerging scientific arenas that includes nanotoxicity. We have reviewed informations uncover link toxicology nanotoxicology applications. addition details about interaction biological system, this article offers concise evaluation developments various nanoinformatics domains. detail, molecular docking, QSAR, etc. prediction nanotoxicity here described. Moreover, techniques dynamics simulations used collection translation standard formats are explored.

Language: Английский

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Green synthesis and characterization of silver nanoparticles with different solvent extracts of Sesbania grandiflora (L.) Poiret and assessment of their antibacterial and antioxidant potentials

Biomass Conversion and Biorefinery, Journal Year: 2023, Volume and Issue: unknown

Published: Aug. 17, 2023

Language: Английский

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Dy3+ ion-doped lithium nickel nanoparticles: Preparation and investigation of nanomagnetic ferrite for antimicrobial applications

Polyhedron, Journal Year: 2025, Volume and Issue: 269, P. 117397 - 117397

Published: Jan. 10, 2025

Language: Английский

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Nanotecnología y su impacto en la biología moderna

South Florida Journal of Development, Journal Year: 2025, Volume and Issue: 6(2), P. e5008 - e5008

Published: Feb. 24, 2025

La nanotecnología ha transformado la biología moderna, abriendo nuevas posibilidades en el diagnóstico, tratamiento y prevención de enfermedades. Este artículo profundiza cómo nanomedicina impulsado avances clave, como administración dirigida fármacos, que reduce los efectos secundarios mejora eficacia terapias contra cáncer enfermedades cardiovasculares. Se exploran sistemas nanoliposomas, las nanopartículas dendrímeros, permiten liberar medicamentos manera controlada protegerlos su degradación. Además, se destaca papel crucial desarrollo vacunas, basadas ácido ribonucleico (ARN) mensajero para combatir COVID-19, perfeccionamiento técnicas diagnóstico a través nanobiosensores electroquímicos métodos innovadores combinan inteligencia artificial aprendizaje automático una medicina más precisa. El también aborda funcionalización nanomateriales permitido dirigidas áreas cáncer, infecciosas afecciones cardiovasculares, así detección temprana biomarcadores. Sin embargo, no pasan por alto desafíos, toxicidad biocompatibilidad estos materiales, lo exige evaluaciones rigurosas modelos celulares tridimensionales regulaciones éticas aseguren uso seguro. En resumen, este trabajo subraya enorme potencial revolucionar destacando sus aplicaciones médicas retos deben superarse garantizar implementación efectiva segura, promoviendo colaboración interdisciplinaria acerque científicos práctica clínica.

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