BioNanoScience, Journal Year: 2024, Volume and Issue: 15(1)
Published: Dec. 5, 2024
Language: Английский
Sustainability, Journal Year: 2024, Volume and Issue: 16(7), P. 2673 - 2673
Published: March 25, 2024
The technology of obtaining porous nanostructures is based on ecological organosilicon materials and their uses in some spheres human life, for example, medical preparations, thermal insulation building structures industrial equipment, cleaning. purpose this study was to establish correlations between various experimental parameters (shear stress, speed pulsations, temperature, viscosity, processing time) the rheological characteristics suspensions obtained by method liquid-phase dispersion; it a hydrodynamic effects processes heat mass exchange liquid systems during dispersion hydrogel monoliths means discrete-pulse activation special rotary apparatus. dehydration hydrogels carried out two methods: convective drying layer spraying coolant flow. Experiments have shown that key stable homogeneous are synergistic combination concentration factors time. To obtain adsorbents form pastes with specified adsorption properties monolith size up 300 μm, optimal were 70% time double-recirculation mode. Xerogels polydisperse mixture strong fragile aggregates. In contrast, xerogel spray show great homogeneity terms strength characteristics. dispersions, which depend treatment modes, dominant affecting moisture extraction drying. This marks first investigation into resilience against influence intense turbulence fields mechanical stresses experienced within rotor apparatus suspension production.
Language: Английский
Citations
1
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(8), P. 975 - 975
Published: July 24, 2024
Isoliquiritigenin (ISL) has excellent neuroprotective effects. However, its limitations, including poor solubility, low bioavailability, and accumulation in the brain, restrict clinical promotion. In this study, a novel type of ISL-loaded liposome (ISL-LP) modified with brain-targeting polypeptide angiopep-2 was prepared to improve these properties. The zeta potential, morphology, particle size, encapsulation efficiency, drug loading, vitro release ISL-LP were evaluated. pharmacokinetics tissue distribution ISL also investigated. results demonstrated that had an average size 89.36 ± 5.04 nm, polymer dispersity index 0.17 0.03, potential -20.27 2.18 mV, efficiency 75.04 3.28%. experiments indicate is desirable sustained-release system. After intravenous administration, LPC-LP prolonged circulation time vivo enhanced relative brain uptake. conclusion, could serve as promising system for treatment prevention central nervous (CNS) disorders.
Language: Английский
Citations
1
Nanomedicine, Journal Year: 2024, Volume and Issue: 19(24), P. 2027 - 2043
Published: Aug. 7, 2024
The post COVID-19 pandemic era has emerged with more efficient vaccines, all based on genetic materials. However, to expand the use of nucleic components as a new generation nanosystems particularly constructed increase RNA/DNA stability, half-life and facilitate administration are still required. This review highlights novel developments in mRNA pDNA vaccines formulated into nanostructures exclusively composed by biopolymeric Recent advances suggest that may arise adapting structural features biopolymers effectiveness acids. advantages offered biopolymers, such increased stability targeting ability cause revolution immunization field for offering promptly adaptable effective formulations worldwide distribution.
Language: Английский
Citations
1
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(11), P. 1475 - 1475
Published: Nov. 19, 2024
The prevalence of female reproductive system disorders is increasing, especially among women age, significantly impacting their quality life and overall health. Managing these diseases effectively challenging due to the complex nature system, characterized by dynamic physiological environments intricate anatomical structures. Innovative drug delivery approaches are necessary facilitate precise regulation manipulation biological tissues. Nanotechnology increasingly considered manage disorders, for example, nanomaterial imaging allows early detection enhances diagnostic precision determine disease severity progression. Additionally, nano systems gaining attention ability target successfully, thereby increasing therapeutic efficacy decreasing side effects. This comprehensive review outlines anatomy upper genital tract highlighting mucosal barriers impact on systemic local delivery. Advances in described sustainable action increased biocompatibility highlight potential strategies managing disorders.
Language: Английский
Citations
1
BioNanoScience, Journal Year: 2024, Volume and Issue: 15(1)
Published: Dec. 5, 2024
Language: Английский
Citations
1