Recent Advances in Multifunctional Naturally Derived Bioadhesives for Tissue Engineering and Wound Management

Polymers for Advanced Technologies, Journal Year: 2024, Volume and Issue: 35(12)

Published: Dec. 1, 2024

ABSTRACT Recent advancements in naturally derived bioadhesives have transformed their application across diverse medical fields, including tissue engineering, wound management, and surgery. This review focuses on the innovative development multifunctional nature of these bioadhesives, particularly emphasizing role enhancing adhesion performance wet environments optimizing mechanical properties for use dynamic tissues. Key areas covered include chemical physical mechanisms adhesion, incorporation multi‐adhesion strategies that combine covalent non‐covalent bonding, bioinspired designs mimicking natural adhesives such as those barnacles mussels. Additionally, discusses emerging applications regeneration musculoskeletal, cardiac, neural, ocular tissues, highlighting potential bioadhesive‐based therapies complex biological settings. Despite substantial progress, challenges scaling lab‐based innovations clinical overcoming environmental constraints remain critical. Ongoing research bioadhesive technologies aims to bridge gaps, promising significant improvements tailored therapeutic needs.

Language: Английский

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Gelatin-Based Hydrogel Functionalized with Dopamine and Layered Double Hydroxide for Wound Healing

Gels, Journal Year: 2024, Volume and Issue: 10(5), P. 318 - 318

Published: May 7, 2024

Hydrogels with adhesion properties and a wetted structure are promising alternatives to traditional wound dressing materials. The insufficiency of gelatin hydrogels in terms their adhesive mechanical strength limits application dressings. This work presents the design preparation gelatin-based hydrogel functionalized dopamine (DA) layered double hydroxide (LDH). combination DA LDH improves hydrogel’s interfacial inner cohesion. 8% 4% attained highest 266.5 kPa, which increased 295.5 343.3 kPa after hydrophobically modifying octanoyl decanoyl aldehydes, respectively. also demonstrated macroporous structure, excellent biocompatibility, good anti-inflammatory effect. developed accelerated healing Sprague Dawley rat skin full-thickness models.

Language: Английский

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Synthesis and characterisation of photocurable poly(glycerol sebacate)-co-poly(ethylene glycol) methacrylates

Materials Today Advances, Journal Year: 2023, Volume and Issue: 19, P. 100410 - 100410

Published: July 28, 2023

Poly (glycerol sebacate)-co-poly (ethylene glycol) (PGS-co-PEG) copolymers have multifunctional and tunable properties great potential as high-performance biomaterials. However, the application of these materials is currently limited by harsh crosslinking conditions that include high temperatures long reaction times. In this study, in order to overcome limitations, methacrylation process was conducted on PGS-co-PEG, resulting photocurable (PGS-co-PEG)-M copolymers. Methacrylation formulated respectively from polyethylene glycol (PEG2) or glycerol ethoxylate (PEG3), investigated for first time. (PGS-co-PEG2)-M (PGS-co-PEG3)-M were found be biodegradable, biocompatible, bioadhesive, pH-responsive photocurable. Multifunctional characteristics remained after methacrylation, they were, however, drastically altered. Mechanical strength enhanced significantly Tensile Young's moduli samples ranged 0.08 0.48 MPa, while those 2.67 35.47 indicating mechanical can tuned via density. contrast, bioadhesive properties, such lap-shear adhesion strengths, almost halved due methacrylation. The degradation swelling rates slightly reduced, but behaviours at pH = 5.0, 7.4 9.1 still observed. Cell metabolic activity double-stranded DNA content, resazurin PicoGreen® assays, demonstrated biocompatible. Photocurable facilitate a simple user-friendly curing (photocrosslinking) could used biomedical applications. Moreover, are beneficial various biofabrication methods, including emulsion techniques additive manufacturing, either directly indirectly.

Language: Английский

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Biomaterial-assisted local oxygenation safeguards the prostimulatory phenotype and functions of human dendritic cells in hypoxia

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 7, 2023

Dendritic cells (DCs), professional antigen-presenting cells, function as sentinels of the immune system. DCs initiate and fine-tune adaptive responses by presenting antigenic peptides to B T lymphocytes mount an effective response against cancer pathogens. However, hypoxia, a condition characterized low oxygen (O 2 ) tension in different tissues, significantly impacts DC functions, including antigen uptake, activation maturation, migration, well T-cell priming proliferation. In this study, we employed O -releasing biomaterials -cryogels) study effect localized supply on human phenotype functions. Our results indicate that -cryogels effectively mitigate exposure hypoxia under hypoxic conditions. Additionally, counteract hypoxia-induced inhibition uptake migratory activity through release hyaluronic acid (HA) mediated mechanisms. Furthermore, preserve restore maturation co-stimulation markers, HLA-DR, CD86, CD40, along with secretion proinflammatory cytokines Finally, our findings demonstrate supplemental released from cryogels preserves DC-mediated priming, ultimately leading proliferation allogeneic CD3+ cells. This work emphasizes potential local oxygenation powerful immunomodulatory agent improve functions offering new approaches for infectious disease treatments.

Language: Английский

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Injectable Functional Polymeric Cryogels for Biological Applications

Deleted Journal, Journal Year: 2024, Volume and Issue: unknown

Published: May 29, 2024

In recent years, injectable cryogels have been frequently used in various biomedical applications such as tissue engineering, drug delivery, therapeutics, therapy, cell transplantation and immunotherapy. Cryogels, one of the biomaterials with 3D scaffold structures, important properties biocompatibility, physical resistance, macropore sensitivity. addition to being biocompatible, cryogels, consisting three-dimensional (3D) scaffolds physicochemical elasticity, hardness biological degradation, provide a structural support environment for development along attachment. addition, can be loaded therapeutic agents or cells engineering clinical studies. The purpose this review is explain chemical scaffolding, after explaining synthesis stages it thought guide make their use different areas more widespread future

Language: Английский

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