PeerJ,
Journal Year:
2024,
Volume and Issue:
12, P. e17143 - e17143
Published: April 10, 2024
Phage
display
technology
has
become
an
important
research
tool
in
biological
research,
fundamentally
changing
the
traditional
monoclonal
antibody
preparation
process,
and
been
widely
used
establishment
of
antigen-antibody
libraries,
drug
design,
vaccine
pathogen
detection,
gene
therapy,
antigenic
epitope
cellular
signal
transduction
research.The
phage
is
a
powerful
platform
for
development.
Using
technology,
single
chain
fragment
variable
(scFv)
can
be
screened,
replacing
disadvantage
large
size
antibodies.
libraries
have
significant
implications.
Here
we
describe
types
antibodies,
including
chimeric
bispecific
scFvs.
In
addition,
system,
screening
specific
antibodies
by
application
libraries.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: May 28, 2024
Ovarian
cancer,
ranking
as
the
seventh
most
prevalent
malignancy
among
women
globally,
faces
significant
challenges
in
diagnosis
and
therapeutic
intervention.
The
difficulties
early
detection
are
amplified
by
limitations
inefficacies
inherent
current
screening
methodologies,
highlighting
a
pressing
need
for
more
efficacious
diagnostic
treatment
strategies.
Phage
display
technology
emerges
pivotal
innovation
this
context,
utilizing
extensive
phage-peptide
libraries
to
identify
ligands
with
specificity
cancer
cell
markers,
thus
enabling
precision-targeted
This
promises
paradigm
shift
ovarian
management,
concentrating
on
targeted
drug
delivery
systems
improve
accuracy
efficacy
while
minimizing
adverse
effects.
Through
meticulous
review,
paper
evaluates
revolutionary
potential
of
phage
enhancing
therapy,
representing
advancement
combating
challenging
disease.
is
heralded
an
essential
instrument
developing
effective
immunodiagnostic
approaches
facilitating
detection,
medication,
implementation
customized
plans.
Targets,
Journal Year:
2024,
Volume and Issue:
2(3), P. 157 - 185
Published: July 8, 2024
Facing
the
increasingly
global
crisis
of
antibiotic
resistance,
it
is
urgent
to
develop
new
antibacterial
agents
and
methods.
Simultaneously,
as
research
progresses,
occurrence,
development,
treatment
diseases,
especially
some
malignant
cancers,
are
found
be
closely
associated
with
bacterial
microenvironment,
prompting
us
reconsider
efficiency
existing
strategies
for
disease
treatments.
Bacteriophages
have
been
employed
an
extended
period
owing
their
high
biocompatibility
particular
targetability
toward
host
strains.
Nonetheless,
they
almost
neglected
due
slow
limited
efficacy
in
practice,
acute
severe
infectious
cases.
In
recent
years,
fantastic
advancements
various
biochemical
technologies,
such
bacteriophage
display
technology,
genetic
engineering,
chemical
molecular
enabled
scientists
conduct
a
broader
range
modifications
transformations
on
bacteriophages
inherited
unique
characteristics
themselves.
As
result,
series
novel
platforms
designed
fabricated
significantly
enhanced
properties
multiplied
functionalities.
These
offer
avenues
combating
infections
caused
by
drug-resistant
bacteria
malignancies
that
infections,
holding
great
significance
potential
innovative
theranostic
applications.
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
14
Published: Jan. 16, 2024
Stroke
poses
a
critical
global
health
challenge,
leading
to
substantial
morbidity
and
mortality.
Existing
treatments
often
miss
vital
timeframes
encounter
limitations
due
adverse
effects,
prompting
the
pursuit
of
innovative
approaches
restore
compromised
brain
function.
This
review
explores
potential
filamentous
phages
in
enhancing
stroke
recovery.
Initially
antimicrobial-centric,
bacteriophage
therapy
has
evolved
into
regenerative
solution.
We
explore
diverse
role
post-stroke
neurological
restoration,
emphasizing
their
ability
integrate
peptides
phage
coat
proteins,
thereby
facilitating
Experimental
evidence
supports
efficacy
alleviating
complications,
immune
modulation,
tissue
regeneration.
However,
rigorous
clinical
validation
is
essential
address
challenges
like
dosing
administration
routes.
Additionally,
genetic
modification
enhances
as
injectable
biomaterials
for
complex
issues.
emphasizes
strategies
capacity
contribute
enhanced
recovery,
opposed
serving
standalone
treatment,
particularly
addressing
stroke-induced
damage.
PeerJ,
Journal Year:
2024,
Volume and Issue:
12, P. e17143 - e17143
Published: April 10, 2024
Phage
display
technology
has
become
an
important
research
tool
in
biological
research,
fundamentally
changing
the
traditional
monoclonal
antibody
preparation
process,
and
been
widely
used
establishment
of
antigen-antibody
libraries,
drug
design,
vaccine
pathogen
detection,
gene
therapy,
antigenic
epitope
cellular
signal
transduction
research.The
phage
is
a
powerful
platform
for
development.
Using
technology,
single
chain
fragment
variable
(scFv)
can
be
screened,
replacing
disadvantage
large
size
antibodies.
libraries
have
significant
implications.
Here
we
describe
types
antibodies,
including
chimeric
bispecific
scFvs.
In
addition,
system,
screening
specific
antibodies
by
application
libraries.
