Emerging polymeric materials for treatment of oral diseases: design strategy towards a unique oral environment

Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(7), P. 3273 - 3301

Published: Jan. 1, 2024

Oral diseases are prevalent but challenging owing to the highly movable and wet, microbial inflammatory environment. Polymeric materials regarded as one of most promising biomaterials due their good compatibility, facile preparation, flexible design obtain multifunctionality. Therefore, a variety strategies have been employed develop with improved therapeutic efficacy by overcoming physicobiological barriers in oral diseases. In this review, we summarize polymeric for treatment First, present unique environment including environment, which hinders effective Second, series designing towards such highlighted. For example, multifunctional armed wet-adhesive, antimicrobial, anti-inflammatory functions through advanced chemistry nanotechnology effectively treat These achieved wet-adhesive polymers modified hydroxy, amine, quinone, aldehyde groups provide strong wet-adhesion hydrogen covalent bonding, electrostatic hydrophobic interactions, developing antimicrobial cationic polymers, peptides, antibiotic-conjugated synthesizing phenolic hydroxy cysteine that function immunomodulators electron donors reactive oxygen species reduce inflammation. Third, various delivery systems enhanced mucosa biofilm penetration capabilities, nanoparticles, hydrogels, patches, microneedles, constructed antibiotics, immunomodulators, antioxidants achieve efficacy. Finally, insights into challenges future development promise clinical translation.

Language: Английский

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Current Trends and Research Advances on the Application of TiO2 Nanoparticles in Dentistry: How Far Are We from Clinical Translation?

Heliyon, Journal Year: 2025, Volume and Issue: unknown, P. e42169 - e42169

Published: Jan. 1, 2025

The great potential of nanotechnology-based knowledge during the past decade has shown to elevate human living standards and enhance healthcare conditions through diagnosing, preventing, treating different diseases. Among abundant nanoparticles (NPs), inorganic NPs feature distinctive biological physicochemical properties compared their conventional counterparts which do not endow. TiO2 possess excellent including low-cast, antibacterial properties, biocompatibility, stability. present review highlights discusses current trends in applying dentistry ranging from TiO2-based nanocomposite endodontics, orthodontics, biofilm prevention. Moreover, developing new photodynamic therapy next generation oral care products is outlined. In end, clinical translation dental materials brought forefront impetus importance NP-based materials.

Language: Английский

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Photodynamic Antibacterial Therapy of Gallic Acid-Derived Carbon-Based Nanoparticles (GACNPs): Synthesis, Characterization, and Hydrogel Formulation

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(2), P. 254 - 254

Published: Feb. 9, 2024

Carbon-based nanoparticles (CNPs) have gained recognition because of their good biocompatibility, easy preparation, and excellent phototherapy properties. In biomedicine applications, CNPs are widely applied as photodynamic agents for antibacterial purposes. Photodynamic therapy has been considered a candidate its noninvasiveness minimal side effects, especially in the improvement activity against multidrug-resistant bacteria, compared with conventional antibiotic medicines. Here, we developed from an active polyhydroxy phenolic compound, namely, gallic acid, which abundant hydroxyl groups that can yield effects. Gallic acid (GACNPs) were rapidly fabricated via microwave-assisted technique at 200 °C 20 min. GACNPs revealed notable properties Gram-positive Gram-negative including Staphylococcus aureus (S. aureus) Escherichia coli (E. coli). The minimum inhibitory concentrations S. E. equal approximately 0.29 mg/mL considerably lower than those solution. Furthermore, GACNP-loaded hydrogel patches demonstrated attractive effect aureus, it was superior to Ag hydrofiber®, commercial material. Therefore, be potentially used development hydrogels wound healing applications.

Language: Английский

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Electrospun fibers based anisotropic silk fibroin film with photodynamic antibacterial therapy for S. aureus infected wound healing

International Journal of Biological Macromolecules, Journal Year: 2023, Volume and Issue: 254, P. 127685 - 127685

Published: Oct. 30, 2023

Language: Английский

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Synthesis and characterization of ZnO nanoparticles for dental applications: Improving the mechanical properties of the temporary dental filling materials

Journal of materials research/Pratt's guide to venture capital sources, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Language: Английский

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Nanotherapies Based on ROS Regulation in Oral Diseases

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Abstract Oral diseases rank among the most prevalent clinical conditions globally, typically involving detrimental factors such as infection, inflammation, and injury in their occurrence, development, outcomes. The concentration of reactive oxygen species (ROS) within cells has been demonstrated a pivotal player modulating these intricate pathological processes, exerting significant roles restoring oral functionality maintaining tissue structural integrity. Due to enzyme‐like catalytic properties, unique composition, intelligent design, ROS‐based nanomaterials have garnered considerable attention nanomedicine. Such capacity influence spatiotemporal dynamics ROS biological systems, guiding evolution intra‐ROS facilitate therapeutic interventions. This paper reviews latest advancements functional customization, medical applications nanomaterials. Through analysis components designs various novel nanozymes nanoplatforms responsive different stimuli dimensions, it elaborates on impacts dynamic behavior potential regulatory mechanisms body. Furthermore, discusses prospects strategies nanotherapies based scavenging generation diseases, offering alternative insights for design development treating ROS‐related conditions.

Language: Английский

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New Advances in Periodontal Functional Materials Based on Antibacterial, Anti‐Inflammatory, and Tissue Regeneration Strategies

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 2, 2025

With the global population aging, awareness of oral health is rising. Periodontitis, a widespread bacterial infectious disease, gaining attention. Current novel biomaterials address key clinical issues like infection, gum inflammation, tooth loosening, and loss, focusing on antibacterial, anti-inflammatory, tissue regeneration properties. However, strategies that integrate advantages these to achieve synergistic therapeutic effects by clearing biofilms, inhibiting inflammation activation, restoring periodontal soft hard functions remain very limited. Recent studies highlight link between periodontitis systemic diseases, underscoring complexity disease. There an urgent need find comprehensive treatment plans requirements. Whether integrating new enhance existing treatments or developing approaches replace traditional therapies, efforts will drive advancements in treatment. Therefore, this review compares with treatments. It highlights design concepts mechanisms functional materials, their properties, discusses importance strategies. This aims provide guidance for emerging research promote development precise efficient

Language: Английский

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Novel Quaternary Ammonium Urethane-Dimethacrylates for Copolymers with Low Water Sorption and Solubility

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 769 - 769

Published: Feb. 7, 2025

Six novel urethane-dimethacrylates with quaternary ammonium groups (QAUDMAs) were successfully synthesized from 2-(methacryloyloxy)ethyl-2-hydroxyethylmethylalkylammonium bromide (QAHAMA-n, where n was 8 and 10) diisocyanate (isophorone (IPDI), 4,4'-methylenedicyclohexyl (CHMDI), 4,4'-diphenylmethane (MDI)). Their chemical structures confirmed through nuclear magnetic resonance spectroscopy (NMR) Fourier transform infrared (FTIR). The refractive index (RI) density (dm) also determined. QAUDMAs compounded common dental dimethacrylates subsequently photopolymerized. resulting copolymers, comprising QAUDMA 40 wt.%, bisphenol A glycerolate dimethacrylate (Bis-GMA) triethylene glycol (TEGDMA) 20 tested for water sorption (WS) solubility (SL). WS SL values decreased following these orderings based on the diisocyanate: IPDI > CHMDI MDI WS, SL. ranged 11.50 to 13.82 µg/mm3, significantly lower than recommended maximum materials, µg/mm3. that met maximum, 7.5 2.67 6.75 Only copolymer having QAHAMA-8- MDI-derived had slightly exceeding at 7.89

Language: Английский

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Applications of nanotherapeutics and nanotheranostics in the management of various bacterial infections

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 307 - 338

Published: Jan. 1, 2025

Language: Английский

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Addressing the silent killer: Nanotechnology for preventing oral bacteria-induced cardiovascular risks

Deleted Journal, Journal Year: 2025, Volume and Issue: 9(1)

Published: March 4, 2025

Tooth extraction, while essential for oral health, can contribute to systemic complications, particularly increasing cardiovascular risk due bacterial translocation and inflammation. Periodontal disease, a major cause of tooth loss, exacerbates this by serving as reservoir pathogenic bacteria that enter the bloodstream during extractions. This review explores mechanisms linking post-extraction infections diseases evaluates role nanotechnology in mitigating these risks. Advances antimicrobial nanoparticles, nanodrug delivery systems, biosensors offer promising solutions infection control targeted drug delivery. These innovations enhance healing potentially reducing However, challenges remain optimizing material biocompatibility, ensuring clinical efficacy, addressing translational hurdles. underscores need interdisciplinary research integrate into dental practice, ultimately improving both health outcomes.

Language: Английский

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