Medical Device-Associated Infections Caused by Biofilm-Forming Microbial Pathogens and Controlling Strategies

Antibiotics, Journal Year: 2024, Volume and Issue: 13(7), P. 623 - 623

Published: July 4, 2024

Hospital-acquired infections, also known as nosocomial include bloodstream surgical site skin and soft tissue respiratory tract urinary infections. According to reports, Gram-positive Gram-negative pathogenic bacteria account for up 70% of infections in intensive care unit (ICU) patients. Biofilm production is a main virulence mechanism distinguishing feature bacterial pathogens. Most pathogens develop biofilms at the solid-liquid air-liquid interfaces. An essential requirement biofilm presence conditioning film. A film provides first surface on which can adhere fosters growth by creating favorable environment. The improves microbial adherence delivering chemical signals or generating microenvironments. Microorganisms use this coating nutrient source. gathers both inorganic organic substances from its surroundings, these are generated microbes These nutrients boost initial adhering facilitate formation acting food Coatings with combined antibacterial efficacy antifouling properties provide further benefits preventing dead cells debris surfaces. In present review, we address numerous that form surfaces biomedical devices. addition, explore several efficient smart antiadhesive coatings device-relevant materials manage caused biofilm-forming

Language: Английский

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Biochemistry of Bacterial Biofilm: Insights into Antibiotic Resistance Mechanisms and Therapeutic Intervention

Life, Journal Year: 2025, Volume and Issue: 15(1), P. 49 - 49

Published: Jan. 2, 2025

Biofilms, composed of structured communities bacteria embedded in a self-produced extracellular matrix, pose significant challenge due to their heightened resistance antibiotics and immune responses. This review highlights the mechanisms underpinning antibiotic within bacterial biofilms, elucidating adaptive strategies employed by microorganisms withstand conventional antimicrobial agents. encompasses role altered gene expression, formation persister cells, contributing recalcitrance biofilms eradication. A comprehensive understanding these provides for exploring innovative therapeutic interventions. study explores promising avenues future research, emphasizing necessity uncovering specific genetic phenotypic adaptations occurring biofilms. The identification vulnerabilities biofilm architecture elucidation key biofilm-specific targets emerge as crucial focal points development targeted strategies. In addressing limitations traditional antibiotics, this discusses approaches. Nanomaterials with inherent properties, quorum-sensing inhibitors disrupting communication, bacteriophages viral agents are highlighted potential alternatives. exploration combination therapies, involving agents, biofilm-disrupting enzymes, immunomodulators, is emphasized enhance efficacy existing treatments overcome resilience.

Language: Английский

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Nanocomposites against Pseudomonas aeruginosa biofilms: Recent advances, challenges, and future prospects

Microbiological Research, Journal Year: 2024, Volume and Issue: 282, P. 127656 - 127656

Published: Feb. 28, 2024

Language: Английский

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A self-supplied hydrogen peroxide and nitric oxide-generating nanoplatform enhances the efficacy of chemodynamic therapy for biofilm eradication

Journal of Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 678, P. 20 - 29

Published: Aug. 22, 2024

Language: Английский

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Dendritic Antifungal Peptides as Potent Agents against Drug-Resistant Candida albicans and Biofilm

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Candida albicans infection is a major public health problem, exacerbated by the emergence of drug-resistant fungi with widespread use antifungal drugs. Therefore, development novel drugs for C. infections crucial. We constructed series dendritic peptides (AFPs) different chain lengths fatty acids as hydrophobic ends and 2 or 3 protease-stable repeats (Arg-Pro) peptide branches. Among them, C4-3RP exhibited excellent antidrug-resistant fungal biofilm activity (GMall = 5.04 μM) was nontoxic. Furthermore, demonstrated high protease stability salt ion tolerance, making it highly effective in murine skin mediated albicans. In addition, uses multiple mechanisms action to achieve effects. conclusion, construction holds substantial potential treatment provides broader perspective on design peptide-based

Language: Английский

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Structure Protects Function: A Multilevel Engineered Surface Modification Renders the Surface of Titanium Dental Implants Resistant to Bacterial Colonization

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

The global dental implant market is projected to reach $9.5 billion by 2032, growing at a 6.5% compound annual growth rate due the rising prevalence of diseases. Importantly, this raises concerns about postoperative infections, which present significant challenges within our healthcare system and lead two-thirds failure for infected implants. In study, we an innovative multilevel coating that makes surface titanium implants resistant bacterial colonization, thereby minimizing risk infection development. This features nanometer-thick biohybrid layer combined with microgroove microstructuring, creating physical barriers enhance stability biohybrids against mechanical abrasion. Our demonstrates excellent biocompatibility strong antifouling properties undiluted blood plasma proteins. Furthermore, combination microstructuring remains stable under prolonged stress simulation effectively repels clinically relevant bacteria, achieving 99% reduction in colonization on implant. These findings underscore potential approach prevent implant-associated infections highlight critical role engineering ensuring long-term performance.

Language: Английский

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The Impact of Fluid Flow on Microbial Growth and Distribution in Food Processing Systems

Foods, Journal Year: 2025, Volume and Issue: 14(3), P. 401 - 401

Published: Jan. 26, 2025

This article examines the impact of fluid flow dynamics on microbial growth, distribution, and control within food processing systems. Fluid flows, specifically laminar turbulent significantly influence behaviors, such as biofilm development adhesion. Laminar is highly conducive to formation attachment because smooth steady. makes it much more difficult sterilize surface. Turbulent flow, however, due its chaotic motion shear forces that are present, inhibits growth disrupts attachment; also has potential contaminate surfaces by dispersing microorganisms. Computational (CFD) highlighted an essential component for processors predict movement enhance numerous fluid-dependent operations, including mixing, cooling, spray drying, heat transfer. analysis underscores significance in controlling hazards settings, discusses some interventions, antimicrobial surface treatments properly designed equipment. Each process step from mixing which influences transfer ensuring uniform distribution optimizing removal, presents unique requirements affecting formation, contamination control. Food can improve management product safety adjusting rates, types, equipment configurations. helps provide understanding fluid–microbe interactions offers actionable insights advance practices, higher standards quality

Language: Английский

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Designing Effective Antimicrobial Agents: Structural Insights into the Antibiofilm Activity of Ionic Liquids

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Research concerning biofilm control is critical due to the pervasive and resilient nature of biofilms, which pose significant challenges across industrial, environmental, healthcare sectors. Traditional antimicrobial treatments are often ineffective against these robust structures. Here, we explore properties ionic liquids (ILs) their efficacy in disruption. By examining structural variations ILs, highlight key role hydrophobicity, noting that longer alkyl side chains IL cations enhance disruption bacterial death. However, upon reaching a certain optimal chain length─usually C12 C14─the activity ILs starts decrease. Furthermore, symmetry size anions significantly impact elimination. This Perspective addresses gap research, revealing structure–activity relationships providing foundation for designing more effective biofilm-disrupting agents.

Language: Английский

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Application of pulsed electric field (PEF) as a strategy to enhance aminoglycosides efficacy against Gram-negative bacteria

Bioelectrochemistry, Journal Year: 2025, Volume and Issue: 164, P. 108935 - 108935

Published: Feb. 6, 2025

Language: Английский

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Systematic review of antibacterial potential in calcium oxide and silicon oxide nanoparticles for clinical and environmental infection control

Journal of Applied Biomedicine, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 10, 2025

A substantial threat to worldwide health, the proliferation of antibiotic-resistant bacteria compels researchers seek innovative antibacterial substances. This systematic review assesses role nanoparticles, particularly Calcium oxide and Silicon in infection control. The article examines mechanisms by which these nanoparticles act against various evaluates their potential as novel agents control strategies. literature search from 2015 2024 encompassing Web Science, PubMed, Wiley, Science Direct, Google Scholar, yielded 70 publications meeting criteria. comprehensive methodology provides a thorough understanding capabilities limitations agents. aims build solid foundation for utilization addressing obstacles presented antibiotic resistance combining data investigations. Additionally, it explore safety environmental implications associated with use clinical settings, providing analysis that may contribute future studies real-world applications field antimicrobial technology.

Language: Английский

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