Advanced Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 23, 2024
Intervertebral
disc
degeneration
(IVDD)
is
characterized
by
fibrosis
of
nucleus
pulposus
(NP)
cells
and
accelerated
surrounding
extracellular
matrix
catabolism.
Bioactive
hydrogels
have
shown
significant
potential
in
regulating
cellular
functions
tissue
homeostasis.
In
this
work,
a
dynamic
hydrogel
(HA-NCSN/Cu)
designed
via
the
reductive
chelation
hyaluronic
acid
grafted
with
thiourea
(HA-NCSN)
Cu
Theranostics,
Journal Year:
2024,
Volume and Issue:
14(11), P. 4438 - 4461
Published: Jan. 1, 2024
The
high
incidence
of
bone
defect-related
diseases
caused
by
trauma,
infection,
and
tumor
resection
has
greatly
stimulated
research
in
the
field
regeneration.
Generally,
healing
is
a
long
complicated
process
wherein
manipulating
biological
activity
interventional
scaffolds
to
support
long-term
regeneration
significant
for
treating
bone-related
diseases.
It
been
reported
that
some
physical
cues
can
act
as
growth
factor
substitutes
promote
osteogenesis
through
continuous
activation
endogenous
signaling
pathways.
This
review
focuses
on
latest
progress
repair
remote
actuation
on-demand
biomaterials
pre-incorporated
with
(heat,
electricity,
magnetism).
As
an
alternative
method
treat
defects,
show
many
advantages,
including
effectiveness,
noninvasiveness,
manipulation.
First,
we
introduce
impact
different
potential
internal
regulatory
mechanisms.
Subsequently,
mediate
various
their
respective
characteristics
are
summarized.
Additionally,
challenges
discussed,
aiming
provide
new
insights
suggestions
developing
intelligent
defects
clinical
translation.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: March 28, 2024
In
this
review,
we
report
investigating
photothermal
hydrogels,
innovative
biomedical
materials
designed
for
infection
control
and
tissue
regeneration.
These
hydrogels
exhibit
responsiveness
to
near-infrared
(NIR)
stimulation,
altering
their
structure
properties,
which
is
pivotal
medical
applications.
Photothermal
have
emerged
as
a
significant
advancement
in
materials,
harnessing
agents
(PTAs)
respond
NIR
light.
This
crucial
controlling
infections
promoting
healing.
We
discuss
three
construction
methods
preparing
emphasizing
design
synthesis,
incorporate
PTAs
achieve
the
desired
effects.
The
application
of
these
demonstrates
enhanced
regeneration,
supported
by
unique
properties.
Although
research
progress
promising,
challenges
remain.
address
issues
explore
future
directions
enhance
therapeutic
potential.
Small Science,
Journal Year:
2024,
Volume and Issue:
4(6)
Published: May 11, 2024
Significance
of
endogenous
mineralization
in
bone
reconstruction
is
paramount,
as
it
facilitates
the
accumulation
calcium
ions
for
tissue
deposition.
However,
conventional
3D‐printed
scaffolds
lack
capacity
ion
enrichment
and
mineralization,
coupled
with
their
low
inductive
activity.
Inspired
from
development
natural
plant
seeds,
a
biomimetic
3D
printing
scaffold
developed
by
implanting
photosensitive
black
phosphorus
“bone
seeds”
(BS),
guiding
sequential
process
mirroring
rooting
(osteoblast
recruitment),
sprouting
(fibrous
callus
mineralization),
flowering
(osseous
formation),
fruiting
(callus
plasticity).
BS
were
trapped
onto
porous
polycaprolactone
(PCL)
aminated
surfaces
via
electrostatic
interactions
between
phosphates
amino
groups,
creating
PCL‐BS
that
can
actively
capture
accelerating
regeneration
critical
defects.
In
vitro
vivo
experiments
show
has
good
biocompatibility
strong
osteogenic
ability
rapid
new
under
near‐infrared
(NIR)
stimulation.
addition,
whole
transcriptome
sequencing
analysis
performed
to
reveal
transcriptomic
mechanism
involved
signal
transduction
network
regulation
during
regeneration.
This
NIR
light‐regulated
inspired
seed
planting,
introduces
pioneering
concept
design
repair
scaffolds.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 6, 2024
Abstract
Managing
fracture
infections
is
a
significant
challenge
in
trauma
orthopedics,
given
the
limited
self‐healing
capacity
of
fractures
and
difficulty
eradicating
infections.
In
this
study,
Cu
2
MoS
4
nanoparticles
(CMSs)
with
are
prepared
enzyme‐like
activity
both
pH
near‐infrared
(NIR)
light
responsiveness.
These
CMSs
combined
methacrylated
gelatin
(GelMA)
to
synthesize
hydrogels
(CMSs@Gel)
antimicrobial
bone
tissue
repair‐promoting
capabilities.
vitro
vivo
experiments,
CMSs@Gel
demonstrated
good
biocompatibility;
peroxidase‐like
(POD),
oxidase‐like
(OXD),
catalase‐like
(CAT)
activities;
excellent
photothermal
conversion
efficiency;
immunomodulatory
capacity.
Furthermore,
exhibited
slow
degradation,
enabling
it
exert
different
pH‐responsive
enzyme
activities
modulate
production
reactive
oxygen
species
(ROS)
polarization
macrophages
throughout
treatment
process.
Notably,
these
effects
significantly
enhanced
under
light.
Additionally,
NIR
irradiation,
maintained
environment
at
mild
temperature
(40–42
°C),
promoting
osteogenesis
angiogenesis.
summary,
enhances
bactericidal
during
infection
effectively
promotes
healing
after
control,
providing
long‐term
therapeutic
effects.
This
study
offers
robust
theoretical
basis
for
staged
future.
Molecules,
Journal Year:
2024,
Volume and Issue:
29(23), P. 5650 - 5650
Published: Nov. 28, 2024
Graphene
oxide-mediated
photothermal
therapy
using
femtosecond
lasers
has
recently
shown
promise
in
treating
hepatocellular
carcinoma.
However,
significant
work
remains
to
optimize
irradiation
parameters
for
specific
nanoparticle
types
and
cancer
cells
improve
nanomaterial-mediated
anticancer
therapy.
This
study
investigated
the
potential
of
nGO
nGO-PEG
nanoparticles
(NPs)
combined
with
laser
at
515
nm
1030
wavelengths,
varying
power
(0.1
0.2
W/cm2)
duration
(5
10
min),
Conversion
efficiency
NPs,
morphology
viability
HepG2
normal
MDCK
after
treatments
were
evaluated
an
electronic
thermometer,
phase-contrast
microscopy,
WST-1
assay.
The
results
revealed
that
NPs
exhibited
better
than
nGO,
inducing
a
temperature
increase
up
19.1
°C
compared
4.7
light.
Laser
exposure
significantly
reduced
cell
viability,
most
intense
conditions
(10
min
causing
decrease
58.2%
43.51%
nGO-PEG.
Normal
showed
minimal
impact
or
slight
increase,
especially
Combined
treatment
induced
morphological
changes
cells,
including
detachment
apoptotic-like
characteristics,
particularly
irradiation.
changes,
some
recovery
observed
under
lower
energy
conditions.
These
findings
suggest
low-energy
engineered
nanomaterials
could
provide
minimally
invasive
approach
side
effects.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: March 27, 2024
Abstract
Background
Osteoarthritis
(OA)
is
a
primary
cause
of
disability
among
the
elderly,
and
its
pathogenesis
unclear.
This
study
explores
correlations
different
meteorological
factors
to
characteristics
outcomes
knee
osteoarthritis
(KOA)
patients
through
2-year
follow-up.
Methods
The
enrolled
70
participants
with
KOA
from
Shanghai,
China
conducted
follow-up
assessment
2
years
later.
Assessment
parameters
included
pain
score,
bone
marrow
abnormality
(BMA)
levels
proinflammatory
cytokine
interleukin-1β
(IL-1β)
IL-6.
Additionally,
data
on
temperature,
wind
speed,
relative
humidity
were
collected
local
stations.
At
baseline,
discretized
into
binary
variables
using
their
respective
median
values.
analysis
associations
between
these
scores,
BMA
cytokines
Mann-Whitney
U
test.
Longitudinally,
mentioned
indicators
determined
multivariate
linear
regression
models.
Results
average
age
individuals
60.6
old.
In
low
temperature
group
had
higher
WOMAC
scores
(p
=
0.022),
increased
IL-1β
<
0.001)
IL-6
0.047)
compared
those
in
high
group.
longitudinal
analysis,
there
notable
fluctuations
alterations
(β=-0.916,
p
0.001),
(β=-0.859,
(β=-0.577,
0.006).
Conclusion
These
findings
provide
evidence
that
has
significant
impact
inflammatory
KOA.
Conversely,
speed
do
not
exhibit
such
effects.
