Materials Today Advances, Journal Year: 2024, Volume and Issue: 24, P. 100542 - 100542
Published: Nov. 30, 2024
Language: Английский
Materials Today Bio, Journal Year: 2024, Volume and Issue: 25, P. 100985 - 100985
Published: Feb. 2, 2024
The repair of critical-sized bone defects poses a significant challenge due to the absence periosteum, which plays crucial role in coordinating processes osteogenesis and vascularization during healing. Herein, we hypothesized that melatonin-encapsuled silk Fibronin electrospun nanofibers (SF@MT) could provide intrinsic induction both angiogenesis, thereby promoting vascularized regeneration. sustained release melatonin from SF@MT resulted favorable biocompatibility superior osteogenic marrow mesenchymal stem cells (BMMSCs). Interestingly, promoted migration tube formation human umbilical vein endothelial (HUVECs) BMMSC-dependent manner, potentially through upregulation vascular growth factor (VEGFA) expression SF@MT-cultured BMMSCs. enhanced BMMSC-mediated angiogenesis by activating PI3K/Akt signaling pathway.
Language: Английский
Citations
8
ACS Biomaterials Science & Engineering, Journal Year: 2024, Volume and Issue: 10(7), P. 4093 - 4113
Published: June 3, 2024
Titanium (Ti) and its alloys are widely used biomaterials in bone repair. Although these possess stable properties good biocompatibility, the high elastic modulus low surface activity of Ti implants have often been associated with infection, inflammation, poor osteogenesis. Therefore, there is an urgent need to modify implants, where changes morphology or coatings loading can confer specific functions help them adapt osseointegration formation phase resist bacterial infection. This further ensure a healthy microenvironment for regeneration as well promotion immunomodulation, angiogenesis, this review, we evaluated various functional after modification, both terms static modifications dynamic response strategies, mainly focusing on synergistic effects antimicrobial activities functionalized osteogenic. Finally, current challenges future perspectives summarized provide innovative effective solutions defect
Language: Английский
Citations
4
Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 160680 - 160680
Published: Feb. 1, 2025
Language: Английский
Citations
0
Biochemical and Biophysical Research Communications, Journal Year: 2025, Volume and Issue: 754, P. 151551 - 151551
Published: Feb. 26, 2025
Language: Английский
Citations
0
Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown
Published: March 4, 2025
Abstract Adipose‐derived stem cells (ADSCs) hold significant promise in bone tissue engineering due to their self‐renewal capacity and easy accessibility. However, limited osteogenic potential remains a critical challenge for clinical application repair. Emerging evidence suggests that circular RNAs (circRNAs) play key role regulating cell fate osteogenesis. Despite this, the specific mechanisms by which circRNAs influence ADSCs context of are largely unexplored. This study introduces novel strategy utilizing circAars, circRNA, modify ADSCs, then incorporated into gelatin methacryloyl (GelMA) hydrogels repair critical‐sized maxillofacial defects. The findings reveal circAars predominantly localizes cytoplasm where it acts as competitive sponge miR‐128‐3p, enhancing differentiation migration capabilities ADSCs. Furthermore, circAars‐engineered facilitate macrophage polarization from M1 M2 phenotype enhance endothelial (EC) angiogenic through paracrine mechanism. Additionally, GelMA scaffolds loaded with accelerate defects synergistically promoting osteogenesis, polarization, angiogenesis. approach offers promising therapeutic treatment
Language: Английский
Citations
0
Bioactive Materials, Journal Year: 2025, Volume and Issue: 49, P. 486 - 501
Published: March 20, 2025
Language: Английский
Citations
0
Biomaterials, Journal Year: 2024, Volume and Issue: 316, P. 122991 - 122991
Published: Dec. 6, 2024
Language: Английский
Citations
2
Virtual and Physical Prototyping, Journal Year: 2024, Volume and Issue: 19(1)
Published: Sept. 26, 2024
Language: Английский
Citations
2
Applied Surface Science, Journal Year: 2024, Volume and Issue: unknown, P. 161596 - 161596
Published: Oct. 1, 2024
Language: Английский
Citations
2
Journal of Dental Sciences, Journal Year: 2024, Volume and Issue: 20(1), P. 350 - 360
Published: July 3, 2024
In-vitro studies are essential for understanding cellular responses, but traditional culture systems often neglect the three-dimensional (3D) structure of real implants, leading to limitations in recruitment and behavior largely governed by gravity. The objective this study was pioneer a novel 3D dynamic osteoblastic system assessing biological capabilities dental implants more clinically physiologically relevant manner. Rat bone marrow-derived osteoblasts were cultured 24-well dish with vertically positioned implant. Controlled rotation using rotator 3° tilts applied. Cell attachment, proliferation, differentiation on implant surfaces evaluated response different surface topographies, physicochemical properties, local environments. Among tested rotational speeds (0, 10, 30, 50 rpm), optimal osteoblast attachment proliferation observed at 30 rpm. A linear correlation found between cell speed up rpm, declining Alkaline phosphatase (ALP) activity mineralized matrix formation elevated newly acid-etched, hydrophilic compared their 4-week-old hydrophobic surfaces. Sandblasted showed higher ALP mineralization. Adding N-acetyl cysteine medium increased Osteoblasts successfully attached, proliferated, vitro under optimized conditions. This differentiated varying wettability, biochemically modulated These findings support developing model, advancing osseointegration research innovating designs.
Language: Английский
Citations
1