Biohacking Nerve Repair: Novel Biomaterials, Local Drug Delivery, Electrical Stimulation, and Allografts to Aid Surgical Repair

Bioengineering, Journal Year: 2024, Volume and Issue: 11(8), P. 776 - 776

Published: July 31, 2024

The regenerative capacity of the peripheral nervous system is limited, and nerve injuries often result in incomplete healing poor outcomes even after repair. Transection that induce a gap necessitate microsurgical intervention; however, current gold standard repair, autologous graft, frequently results functional recovery. Several interventions have been developed to augment surgical repair nerves, application biomaterials, local delivery bioactive substances, electrical stimulation, allografts are among most promising approaches enhance innate across gap. Biocompatible polymers with optimized degradation rates, topographic features, other functions provided by their composition incorporated into novel conduits (NCs). Many these allow for drugs, neurotrophic factors, whole cells locally sites, mitigating adverse effects limit systemic use. stimulation repaired nerves perioperative period has shown benefits recovery human trials, biomaterials show promise preclinical models. use acellular (ANAs) circumvents morbidity donor harvest necessitated autografts, improvements tissue-processing techniques may more readily available cost-effective options. Each aid neural regeneration when applied independently, differing forms, benefits, methods present ample opportunity synergistic combination.

Language: Английский

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Interlacing Biology and Engineering: An Introduction to Textiles and their Application in Tissue Engineering

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101617 - 101617

Published: Feb. 26, 2025

Language: Английский

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Conductive MeCbl/PEDOT:PSS/HA hydrogels with electrical stimulation for enhanced peripheral nerve regeneration

Materials Today Bio, Journal Year: 2025, Volume and Issue: unknown, P. 101755 - 101755

Published: April 1, 2025

Language: Английский

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Therapeutic Advances in Peripheral Nerve Injuries: Nerve-Guided Conduit and Beyond

Tissue Engineering Part B Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Peripheral nerve injury (PNI), a challenging neurosurgery issue, often leads to partial or complete loss of neuronal functions and even neuropathic pain. Thus far, the gold standard for treating peripheral deficit remains autografts. While numerous reviews have explored PNI regeneration, this work distinctively synthesizes recent advancements in tissue engineering-particularly four-dimensional (4D) bioprinting exosome therapies-with an emphasis on their clinical translation. By consolidating findings spanning molecular mechanisms therapeutic applications, review proposes actionable framework advancing experimental strategies toward clinically viable solutions. Our critically evaluates emerging innovations such as dynamically adaptive 4D-printed conduits exosome-based therapies, underscoring potential match conventional autografts achieving functional restoration. Impact Statement Although several previous been made describing with great detail degenerative regenerative nervous systems, well existing exploratory treatment strategies, we focus more latest each those topics.

Language: Английский

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Emerging Frontiers of Conductive Supramolecular Hydrogels in Biomedical Applications

Published: April 1, 2025

Language: Английский

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Electrospinning and electrospun nanofibers: From academic research to industrial production

Progress in Materials Science, Journal Year: 2025, Volume and Issue: unknown, P. 101494 - 101494

Published: April 1, 2025

Language: Английский

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Engineering cell-derived extracellular matrix for peripheral nerve regeneration

Materials Today Bio, Journal Year: 2024, Volume and Issue: 27, P. 101125 - 101125

Published: June 13, 2024

Extracellular matrices (ECMs) play a key role in nerve repair and are recognized as the natural source of biomaterials. In parallel to extensively studied tissue-derived ECMs (ts-ECMs), cell-derived (cd-ECMs) also have capability partially recapitulate complicated regenerative microenvironment native tissues. Notably, cd-ECMs can avoid shortcomings ts-ECMs. Cd-ECMs be prepared by culturing various cells or even autologous vitro under pathogen-free conditions. And mild decellularization achieve efficient removal immunogenic components cd-ECMs. Moreover, more readily customizable desired functional properties. These advantages garnered significant attention for potential neuroregenerative medicine. As promising biomaterials, bring new hope effective treatment peripheral injuries. Herein, this review comprehensively examines current knowledge about characteristics their mechanisms interaction with regeneration, particular focus on preparation, engineering optimization, scalability The applications from distinct cell sources reported tissue highlighted summarized. Furthermore, limitations that should addressed outlooks related clinical translation put forward well.

Language: Английский

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From innovation to clinic: emerging strategies harnessing electrically conductive polymers to enhance electrically stimulated peripheral nerve repair

Materials Today Bio, Journal Year: 2024, Volume and Issue: 30, P. 101415 - 101415

Published: Dec. 19, 2024

Language: Английский

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Bioinspired conductive oriented nanofiber felt with efficient ROS clearance and anti-inflammation for inducing M2 macrophage polarization and accelerating spinal cord injury repair

Bioactive Materials, Journal Year: 2024, Volume and Issue: 46, P. 173 - 194

Published: Dec. 13, 2024

Language: Английский

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Advances in biomaterial-based tissue engineering for peripheral nerve injury repair

Bioactive Materials, Journal Year: 2024, Volume and Issue: 46, P. 150 - 172

Published: Dec. 13, 2024

Language: Английский

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