Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: unknown, P. 104576 - 104576
Published: Nov. 1, 2024
Language: Английский
Frontiers in Immunology, Journal Year: 2025, Volume and Issue: 15
Published: Jan. 7, 2025
Virus-like particles (VLPs), as a unique form of nanocarrier, predominantly encompass hollow protein shells that exhibit analogous morphology and structure to naturally occurring viruses, yet devoid genetic material. VLPs are considered safe, easily modifiable, stable, making them suitable for preparation in various expression systems. They serve precise biological instruments with broad applications the field medical biology. Leveraging their structural attributes facile modification capabilities, can an effective platform delivery tumor antigens, thereby stimulating immune system facilitating eradication cells.
Language: Английский
Citations
1
International Journal of Pharmaceutics, Journal Year: 2024, Volume and Issue: unknown, P. 124994 - 124994
Published: Nov. 1, 2024
Language: Английский
Citations
4
Essays in Biochemistry, Journal Year: 2025, Volume and Issue: 69(02)
Published: March 28, 2025
The emergence of immunotherapy has led to the clinical approval several related drugs. However, their efficacy against solid tumors remains limited. As hub immune activation, lymph nodes (LNs) play a critical role in tumor by initiating and amplifying responses. Nevertheless, intricate physiological structure barriers within LNs, combined with immunosuppressive microenvironment induced cells, significantly impede therapeutic immunotherapy. Engineered nanoparticles (NPs) have shown great potential overcoming these challenges facilitating targeted drug transport LNs directly or indirectly activating T cells. This review systematically examines structural features key factors influencing targeting efficiency NPs, current strategies for remodeling LNs. Additionally, it discusses future opportunities optimizing NPs enhance immunotherapy, addressing translation safety evaluation.
Language: Английский
Citations
0
Frontiers in Oncology, Journal Year: 2025, Volume and Issue: 15
Published: April 17, 2025
Melanoma is highly invasive and resistant to conventional treatments, accounting for nearly 75% of skin cancer-related deaths globally. Traditional therapies, such as chemotherapy immunotherapy, often exhibit limited efficacy are associated with significant side effects due systemic drug exposure. Microneedles (MNs), an emerging delivery system, offer multiple advantages, including safety, painlessness, minimal invasiveness, controlled release. Among these, hydrogel microneedles (HMNs) stand out their extracellular matrix-like structure swelling-induced continuous channels, which enable the direct therapeutic agents into tumor microenvironment (TME). This approach enhances bioavailability while reducing toxicity, establishing HMNs a promising platform melanoma treatment. review highlights recent advancements in therapy, focusing on applications biomarker extraction early diagnosis role supporting multimodal treatment strategies, chemotherapy, phototherapy, targeted combination therapy. Furthermore, current matrix materials fabrication techniques discussed. Finally, limitations critically analyzed, recommendations future research development provided.
Language: Английский
Citations
0
Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15
Published: Aug. 15, 2024
Cancer dissemination to lymph nodes (LN) is associated with a worse prognosis, increased incidence of distant metastases and reduced response therapy. The LN microenvironment puts selective pressure on cancer cells, creating cells that can survive in as well providing survival advantages for metastatic spread. Additionally, the presence leads an immunosuppressive microenvironment, favoring evasion anti-cancer immune surveillance. However, recent studies have also characterized previously unrecognized roles tumor-draining (TDLNs) immunotherapy response, including acting reservoir pre-exhausted CD8+ T stem-like cells. In this review, we will discuss spread through lymphatic system, TDLNs metastasis responses, therapeutic opportunities challenges targeting metastasis.
Language: Английский
Citations
2
RNA Biology, Journal Year: 2024, Volume and Issue: 21(1), P. 17 - 28
Published: Sept. 6, 2024
Circular RNAs (circRNAs) are a class of single-stranded with closed loop lacking 5' and 3' ends. These circRNAs translatable and, therefore, have potential in developing vaccine. CircRNA vaccines been shown to be more stable, safe, easy manufacture scale-up production when compared mRNA vaccines. However, these also suffer from several drawbacks such as low circularization efficiency for longer RNA precursor usage lipid nano particles (LNPs) their delivery. LNPs require large amounts due indirect delivery endosome cytosol. Besides, individual components provide reactogenicity. Usage virus like (VLPs) can improve the increased targeted circRNA show no Moreover, VLPs has used produce against diseases hepatitis C (HCV) etc. In this article, we will discuss about methods enhance synthesis or circRNA. significance vehicle possible dual
Language: Английский
Citations
1
Biomaterials, Journal Year: 2024, Volume and Issue: 316, P. 122998 - 122998
Published: Dec. 9, 2024
Language: Английский
Citations
1
Critical Reviews in Oncology/Hematology, Journal Year: 2024, Volume and Issue: unknown, P. 104576 - 104576
Published: Nov. 1, 2024
Language: Английский
Citations
0