Physicochemical Dual Cross-Linked Multifunctional Conductive Organohydrogel Sensors for Fireworks Burn Wound Healing and Intelligent Real-Time Monitoring DOI Creative Commons
Zhenchun Li,

Yuyang Li,

Zhongwu Zhang

et al.

Polymer science & technology., Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Conductive hydrogels have garnered significant attention in the realm of future flexible electronic devices due to their properties such as flexibility, electrical conductivity, frost resistance, and biocompatibility. However, integration numerous functional applications biomedical field still presents notable challenges. In this research, a rigid hard-structured network was formed by cross-linking gallic acid grafted chitosan (CS–GA) tannic (TA) with poly(vinyl alcohol) (PVA) through physical freezing. The noncovalent hydrogen bonding during freezing thawing process facilitated formation microcrystalline domains amorphous hydrogel system. Functional proteins from eggshell membrane were cross-linked tetra-armed poly(ethylene glycol) maleimide (4am-PEG-MAL) via thiol-olefin click chemistry, lysozyme incorporated into an antibacterial component nucleophilic substitution reaction. These chemical methods resulted soft-structured that enhanced mechanical (maximum stress 2.15 MPa elongation 605%). use ionic liquids/ethylene glycol/water (ILs/EG/H2O) ternary solvents instead single solvent not only provided resistance but also imparted excellent conductivity (0.37 ± 0.04 S/m). Notably, organohydrogel showed good antimicrobial biocompatibility effective providing emergency cooling after fireworks burns promoting wet healing broken skin minimize scarring. field, multifunctional can serve wearable device monitor movement amplitude wounds real-time, offering novel approach deep learning-assisted wound healing. nature biological promising applications.

Language: Английский

Glucose-triggered NIR-responsive photothermal antibacterial gelatin/dextran hydrogel simultaneously targeting the high glucose and infection microenvironment in diabetic wound DOI

Yachao Yu,

Hua Zhao,

Jingmei Liu

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 140325 - 140325

Published: Jan. 1, 2025

Language: Английский

Citations

1
Structure characterization of polysaccharide isolated from Ribes nigrum L. and it's bioactivity against gout DOI
Xianjun Huang,

Sitao Zheng,

Yujia Guo

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141359 - 141359

Published: Feb. 1, 2025

Language: Английский

Citations

0
Progress in Advanced Composite Hydrogel Dressings: Innovative Materials and Designs for the Treatment of Chronic Wounds DOI
Z T Sun, Li Zhao, Fenglong Wang

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(8)

Published: Feb. 1, 2025

Abstract Chronic wounds, as a kind of long‐term disease that is difficult to cure, are challenged in healthcare, placing substantial physical, emotional, and economic burdens on patients society. Effective treatment chronic wounds essential for improving patient quality life, reducing healthcare costs, alleviating the strain medical resources. Hydrogel materials have emerged promising candidates wound due their exceptional adaptability environments ability deliver various therapeutic agents, effectively promoting healing wounds. However, wide array available with diverse functionalities presents challenge selecting most appropriate components synthesizing hydrogel dressings. This review summarizes common materials, including properties, cross‐linking methods, applications. Additionally, it systematically categorizes different elucidating action mechanisms effects. Furthermore, this work offers guidance material selection dressing design based characteristics Finally, challenges future perspectives composite hydrogels field dressings discussed. provides readers comprehensive understanding reliable basis synthesize ideal

Language: Английский

Citations

0
Unravelling the rheological and multifunctionality of Justicia adhatoda-impregnated carboxymethyl cellulose hydrogels for drug delivery systems DOI
Karolinekersin Enoch,

Anbumozhi Angayarkanni

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 141419 - 141419

Published: Feb. 1, 2025

Language: Английский

Citations

0
Bovine Serum Albumin Nanoparticles as Versatile Carriers for Enhancing the Multifunctional Efficacy of Protocatechuic Acid DOI

Abdelrahman Gamal Ahmed Ali Ibrahim,

Adel M. Attia, Heba A. Sahyon

et al.

ChemistrySelect, Journal Year: 2025, Volume and Issue: 10(13)

Published: April 1, 2025

Abstract Protocatechuic acid (PCA) has antioxidant, anticancer, and antidiabetic properties. However, its poor water solubility affects absorption bioavailability. Bovine serum albumin nanoparticles (BSA‐NPs) can encapsulate significant amounts of hydrophobic substances by attracting charged molecules through electrostatic adsorption. This study aimed to prepare PCA‐loaded BSA nanoparticles, producing PCA‐BSA‐NPs, subsequently characterize the resulting nanocomposite using zeta potential, dynamic light scattering, X‐ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM). In vitro, PCA‐BSA‐NPs were evaluated for their free radical scavenging Our data indicated that average particle size was 202 nm. The in vitro demonstrated exhibited potent anticancer activity comparable doxorubicin. Additionally, displayed highly antioxidant (2,2‐diphenyl‐1‐picrylhydrazyl (DPPH), superoxide dismutase (SOD) like activity, catalytic activity) a strong effect ( α ‐amylase inhibition). drug release effective PCA from at pH = 6.5, which is suitable targeting cancer cells. conclusion, could provide more safer alternative traditional chemotherapeutic agents Moreover, higher activities expand therapeutic applications, making them valuable treating oxidative stress‐related diseases diabetes.

Language: Английский

Citations

0
Self-assembled near-infrared-photothermal antibacterial Hericium erinaceus β-glucan/tannic acid/Fe (III) hydrogel for accelerating infected wound healing DOI

Shi‐Kang Chen,

Jin-Jin Liu,

Xin Wang

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 348, P. 122898 - 122898

Published: Oct. 23, 2024

Language: Английский

Citations

3
Construction of natural hydrogels consisting of oxidized dextran, quaternized chitosan and cuttlefish ink nanoparticles for treating diabetic oral ulcers DOI
Jianan Song, Zuojun Geng, Xiaorong Luan

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 283, P. 137737 - 137737

Published: Nov. 17, 2024

Language: Английский

Citations

1
Physicochemical Dual Cross-Linked Multifunctional Conductive Organohydrogel Sensors for Fireworks Burn Wound Healing and Intelligent Real-Time Monitoring DOI Creative Commons
Zhenchun Li,

Yuyang Li,

Zhongwu Zhang

et al.

Polymer science & technology., Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 12, 2024

Conductive hydrogels have garnered significant attention in the realm of future flexible electronic devices due to their properties such as flexibility, electrical conductivity, frost resistance, and biocompatibility. However, integration numerous functional applications biomedical field still presents notable challenges. In this research, a rigid hard-structured network was formed by cross-linking gallic acid grafted chitosan (CS–GA) tannic (TA) with poly(vinyl alcohol) (PVA) through physical freezing. The noncovalent hydrogen bonding during freezing thawing process facilitated formation microcrystalline domains amorphous hydrogel system. Functional proteins from eggshell membrane were cross-linked tetra-armed poly(ethylene glycol) maleimide (4am-PEG-MAL) via thiol-olefin click chemistry, lysozyme incorporated into an antibacterial component nucleophilic substitution reaction. These chemical methods resulted soft-structured that enhanced mechanical (maximum stress 2.15 MPa elongation 605%). use ionic liquids/ethylene glycol/water (ILs/EG/H2O) ternary solvents instead single solvent not only provided resistance but also imparted excellent conductivity (0.37 ± 0.04 S/m). Notably, organohydrogel showed good antimicrobial biocompatibility effective providing emergency cooling after fireworks burns promoting wet healing broken skin minimize scarring. field, multifunctional can serve wearable device monitor movement amplitude wounds real-time, offering novel approach deep learning-assisted wound healing. nature biological promising applications.

Language: Английский

Citations

1