Excipients for Cerium Dioxide Nanoparticle Stabilization in the Perspective of Biomedical Applications DOI Creative Commons

Svetlana A. Titova,

Maria Petrovna Kruglova, Stupin Va

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(6), P. 1210 - 1210

Published: March 8, 2025

Rare earth metal nanoparticles, some of which are already widely used in medicine, growing interest the modern scientific community. One promising rare metals for biomedical applications is cerium, specifically its oxide form, characterized by a higher level stability and safety. According to number studies, cerium dioxide has wide range biological effects (regenerative, antimicrobial, antioxidant, antitumor), justifies potential application medicine. However, these their intensity vary significantly across studies. Since was it can be assumed that not only chemical formula important, but also physicochemical parameters nanoparticles obtained, consequently methods synthesis modification with use excipients. In this review, we considered possibilities using excipients (polyacrylate, polyvinylpyrrolidone, dextran, hyaluronic acid, chitosan, polycarboxylic acids, lecithin, phosphatidylcholine) context preserving properties, as well degree study combinations from point view prospect creating drugs based on applications.

Language: Английский

A Slimming/Excavating Strategy for Enhanced Intratumoral Penetration of Acid‐Disassemblable NO‐Releasing Nanomedicines DOI Open Access
Lingdong Jiang,

An‐Bang Wu,

Lingting Zeng

et al.

Advanced Healthcare Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 5, 2025

Abstract Poor tumor penetration is the major predicament of nanomedicines that limits their anticancer efficacy. The dense extracellular matrix (ECM) in one barriers against deep nanomedicines. In this work, a slimming/excavating strategy proposed for enhanced intratumoral based on an acid‐disassemblable nanomicelles‐assembled nanomedicine and NO‐mediated degradation ECM. constructed by cross‐linking nanomicelles, which are self‐assembled with two kinds dendrimers containing phenylboronic acid lactobionic acid, through borate esterification. acidic microenvironment, pH‐sensitive ester bonds among nanomicelles hydrolyzed, triggering disassembly (≈150 nm) into small (≈25 nm). response to over‐expressed glutathione (GSH), NO donor loaded produces NO, mediates expression metalloproteinases ECM tumor. By collaboration disassembling behavior ECM, designed can penetrate long distance tumors. will provide inspiration overcoming challenge penetration.

Language: Английский

Citations

0
Excipients for Cerium Dioxide Nanoparticle Stabilization in the Perspective of Biomedical Applications DOI Creative Commons

Svetlana A. Titova,

Maria Petrovna Kruglova, Stupin Va

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(6), P. 1210 - 1210

Published: March 8, 2025

Rare earth metal nanoparticles, some of which are already widely used in medicine, growing interest the modern scientific community. One promising rare metals for biomedical applications is cerium, specifically its oxide form, characterized by a higher level stability and safety. According to number studies, cerium dioxide has wide range biological effects (regenerative, antimicrobial, antioxidant, antitumor), justifies potential application medicine. However, these their intensity vary significantly across studies. Since was it can be assumed that not only chemical formula important, but also physicochemical parameters nanoparticles obtained, consequently methods synthesis modification with use excipients. In this review, we considered possibilities using excipients (polyacrylate, polyvinylpyrrolidone, dextran, hyaluronic acid, chitosan, polycarboxylic acids, lecithin, phosphatidylcholine) context preserving properties, as well degree study combinations from point view prospect creating drugs based on applications.

Language: Английский

Citations

0