Biophysical translational paradigm of polymeric nanoparticle: Embarked advancement to brain tumor therapy
Shaikh Sheeran Naser,
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Abha R. Gupta,
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Anmol Choudhury
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et al.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
179, P. 117372 - 117372
Published: Aug. 28, 2024
Polymeric
nanoparticles
have
emerged
as
promising
contenders
for
addressing
the
intricate
challenges
encountered
in
brain
tumor
therapy
due
to
their
distinctive
attributes,
including
adjustable
size,
biocompatibility,
and
controlled
drug
release
kinetics.
This
review
comprehensively
delves
into
latest
developments
synthesizing,
characterizing,
applying
polymeric
explicitly
tailored
therapy.
Various
synthesis
methodologies,
such
emulsion
polymerization,
nanoprecipitation,
template-assisted
fabrication,
are
scrutinized
within
context
of
targeting,
elucidating
advantages
limitations
concerning
traversing
blood-brain
barrier.
Furthermore,
strategies
pertaining
surface
modification
functionalization
expounded
upon
augment
stability,
targeting
prowess
amidst
milieu
microenvironment.
Characterization
techniques
encompassing
dynamic
light
scattering,
transmission
electron
microscopy,
spectroscopic
methods
evaluate
physicochemical
attributes
engineered
Moreover,
a
comprehensive
exploration
manifold
applications
delivery,
gene
therapy,
imaging,
combination
therapies
tumours
is
undertaken.
Special
emphasis
placed
on
encapsulation
diverse
therapeutics
nanoparticles,
thereby
shielding
them
from
degradation
enabling
precise
brain.
Additionally,
recent
advancements
stimuli-responsive
multifunctional
probed
potential
personalized
medicine
theranostics
tumours.
In
essence,
this
furnishes
an
all-encompassing
overview
strides
made
tailoring
illuminating
synthesis,
characterization,
multifaceted
application.
Language: Английский
Recent Advances in Cellulose Nanofiber Modification and Characterization and Cellulose Nanofiber-Based Films for Eco-Friendly Active Food Packaging
Jiaojiao Sun,
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Xi Yang,
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Yifan Bai
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et al.
Foods,
Journal Year:
2024,
Volume and Issue:
13(24), P. 3999 - 3999
Published: Dec. 11, 2024
There
is
growing
interest
in
the
use
of
bio-based
materials
as
viable
alternatives
to
petrochemical-based
packaging.
However,
practical
application
films
often
hampered
by
their
poor
barrier
and
mechanical
properties.
In
this
context,
cellulose
nanofibers
(CNFs)
have
attracted
considerable
attention
owing
exceptional
biodegradability,
high
aspect
ratio,
large
surface
area.
The
extraction
CNFs
from
agricultural
waste
or
non-food
biomass
represents
a
sustainable
approach
that
can
effectively
balance
cost
environmental
impacts.
functionalization
improves
economics
raw
production
processes
while
expanding
applications.
This
paper
reviews
recent
advances
nanofibers,
including
sources,
modification,
characterization
techniques.
Furthermore,
we
systematically
discuss
interactions
with
different
composites
development
functional
food
films.
Finally,
highlight
nanofiber
preservation.
Due
environmentally
friendly
properties,
are
promising
alternative
petroleum-based
plastics.
aim
present
latest
discoveries
exploring
future
prospects
for
edible
films,
thereby
encouraging
further
research
field
active
Language: Английский
Polyethylene microplastics promote nucleus pulposus cell senescence by inducing oxidative stress via TLR4/NOX2 axis
Weilin Zhang,
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Zhencong Li,
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Zhongwei Wang
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et al.
Ecotoxicology and Environmental Safety,
Journal Year:
2025,
Volume and Issue:
292, P. 117950 - 117950
Published: Feb. 27, 2025
This
study
aimed
to
detect
and
characterize
microplastics
in
intervertebral
disc
investigate
their
effects
molecular
mechanism
on
degeneration.
We
collected
tissues
from
cervical,
lumbar,
thoracolumbar
segments
used
Raman
spectroscopy
identify
microplastics.
Among
80
samples,
47
contained
microplastics,
with
polyethylene
being
the
most
prevalent
type.
To
explore
of
(PE-MPs),
we
established
a
mouse
model
nucleus
pulposus
cell
model.
Reactive
oxygen
species
(ROS)
levels
were
assessed
via
immunofluorescence
staining,
viability
was
measured
using
CCK-8
assay,
protein
expression
related
Toll-like
receptor
4
(TLR4)/NADPH
oxidase
2
(NOX2)
axis,
oxidative
stress,
degeneration
evaluated
through
western
blotting
staining.
Results
showed
that
PE-MPs
exposure
led
by
inducing
stress
activating
TLR4
/
NOX2
which
increased
senescence
cells.
These
mitigated
inhibitors.
research
highlights
existence
human
tissue
unveils
novel
induced
PE-MPs,
offering
new
avenues
for
clinical
treatment
microplastic-related
Language: Английский
Photocatalytic Degradation of BPA by Z‐Type Heterojunction FeTiO3@G‐C3N4 Under Visible Light
Ziyi Yang,
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Jinhai Yuan,
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Chunyan Zhong
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et al.
ChemistrySelect,
Journal Year:
2025,
Volume and Issue:
10(13)
Published: April 1, 2025
Abstract
In
this
study,
single‐phase
g‐C
3
N
4
and
FeTiO
catalysts
were
synthesized
by
thermal
polymerization
hydrothermal
methods,
@g‐C
binary
composites
successfully
constructed
method.
The
crystal
structure,
morphology,
photoelectric
properties
of
the
samples
characterized
in
all
aspects
characterization
methods
such
as
XRD,
FI‐IR,
SEM,
XPS,
BET,
UV–vis,
PL,
effects
different
doping
ratios,
catalyst
injection,
initial
concentration
pollutants,
pH,
light
source
on
degradation
performance
bisphenol
A
(BPA)
investigated.
It
was
shown
that
spherical
chalcogenide
particles
loaded
lamellar
surface
to
form
a
composite
with
specific
area
18.403
m
2
/g
pore
size
14.636
nm.
(1:3)
achieved
65.59%
20
mg/L
BPA
solution
under
visible
maintained
58.38%
removal
after
four
cycles,
which
·O
−
·OH
radicals
main
active
species,
process
conformed
quasi‐primary
kinetic
model.
research,
Z‐scheme
heterojunction
is
improve
electron
transport
path
effectively
slow
down
recombination
photogenerated
electrons
holes,
provides
feasible
pathway
for
efficient
novel
BPA,
opens
up
new
direction
photocatalytic
pollution
treatment.
Language: Английский
Release of Microplastics During Dental Procedures and Denture Wear: Impact on Dental Personnel and Patients
Yan Chen,
No information about this author
Jianmin Chen,
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Jingyao Guo
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et al.
Journal of Hazardous Materials,
Journal Year:
2025,
Volume and Issue:
494, P. 138463 - 138463
Published: May 1, 2025
Language: Английский
The unseen perils of oral-care products generated micro/nanoplastics on human health
Utsa Saha,
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Snehasmita Jena,
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Faizan Zarreen Simnani
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et al.
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
290, P. 117526 - 117526
Published: Dec. 13, 2024
Language: Английский
Advancements and Challenges in Nanoscale Zero-Valent Iron-Activated Persulfate Technology for the Removal of Endocrine-Disrupting Chemicals
Dong Liang,
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Guoming Zeng,
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Xiaoling Lei
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et al.
Toxics,
Journal Year:
2024,
Volume and Issue:
12(11), P. 814 - 814
Published: Nov. 13, 2024
Endocrine-disrupting
chemicals
are
a
new
class
of
pollutants
that
can
affect
hormonal
metabolic
processes
in
animals
and
humans.
They
enter
the
aquatic
environment
through
various
pathways
gradually
become
enriched,
thus
posing
serious
threat
to
endocrine
physiological
systems
both
Nano
zero-valent
iron
has
promising
applications
disruptor
removal
due
its
excellent
reducing
properties
high
specific
surface
area.
However,
given
dispersed
focus
fragmented
results
current
studies,
comprehensive
review
is
still
lacking.
In
this
paper,
it
was
analyzed
types
disruptors
their
emission
reveal
sources
these
compounds.
Then,
main
technologies
currently
used
for
treatment
introduced,
covering
physical,
chemical,
biological
methods,
with
special
on
persulfate
oxidation
among
advanced
technologies.
Also,
paper
summarizes
activation
methods
technology
proposes
nZVI-activated
as
most
means
treatment.
addition,
reviews
research
progress
different
modification
nZVI
activating
EDCs.
Finally,
discussion
includes
recycling
studies
nZVI/PS
emphasizes
urgency
importance
The
provides
further
scientific
basis
technical
support
field
management.
Language: Английский