Nanoparticles Modulating the Immune Microenvironment in Breast Cancer Treatment

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 1367 - 1382

Published: Feb. 1, 2025

Abstract: Breast cancer remains a significant therapeutic challenge, with the immune microenvironment playing crucial role in its progression and treatment response. This review investigates potential of nanoparticles to modulate breast therapy. Initially, we discuss composition influence on cancer, followed by current strategies targeting these components. We then provide for cells such as macrophages, dendritic cells, T-cells. The enhancing checkpoint blockade (ICB) their application vaccines is also examined. Additionally, explore synergistic effects combining conventional therapies. addresses challenges clinical translation, focusing safety, biocompatibility, toxicity. Finally, outline future research directions advancements nanoparticle-based immunotherapy, emphasizing transformative impact treatment. Keywords: nanoparticle,

Language: Английский

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Cold Exposure Therapy Enhances Single-Atom Nanozyme-Mediated Cancer Vaccine Therapy

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Single-atom nanozymes are highly effective in the preparation of tumor vaccines (TV) due to their superior peroxidase (POD) activity and excellent biocompatibility. However, immunosuppressive environment within tumors can diminish efficacy these vaccines. Cold exposure (CE) therapy, a noninvasive straightforward antitumor method, not only suppresses metabolism but also ameliorates milieu. In this study, we developed personalized TV using copper single-atom nanozyme (Cu SAZ) enhanced long-term by introducing CE. We initially synthesized Cu SAZ via high-temperature carbonization, which demonstrated robust POD photothermal characteristics. Upon 808 nm laser irradiation, generated reactive oxygen species (ROS) heat, inducing immunogenic cell death 4T1 breast cancer cells or CT26 colon facilitating production. our vivo prevention treatment model, noted that CE significantly boosted TV. The primary mechanism involves CE's ability lower ratio myeloid-derived suppressor (MDSCs), decrease glucose cells, increase proportions CD8+ T memory cells. Collectively, findings offer promising avenues for designing innovative systems.

Language: Английский

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Oxygen-delivery nanoparticles enhanced immunotherapy efficacy monitored by granzyme B PET imaging in malignant tumors

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 7, 2025

Limited treatment response and inadequate monitoring methods stand firmly before successful immunotherapy. Recruiting activating immune cells in the hypoxic tumor microenvironment is key to reversing suppression improving immunotherapy efficacy. In this study, biomimetic oxygen-delivering nanoparticles (CmPF) are engineered for homologous targeting hypoxia alleviation within environment. CmPF targets delivers oxygen reduce hypoxia, thereby promoting cell activity at site. addition, granzyme B-targeted positron emission tomography (PET) imaging employed monitor changes efficacy vivo. The combination of with carboplatin PD-1 inhibitors significantly suppresses growth by 2.4-fold, exhibiting potential enhance Immunohistochemistry further confirms increased expression markers, highlighting reprogramming microenvironment. This study demonstrates that enhances introduces a non-invasive PET method dynamic, real-time assessment therapeutic response.

Language: Английский

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Simultaneous Reversal of T Lymphocytes and Cancer Cells Metabolism Via a Biomimetic Heavy‐Atom‐Free Photosensitizers‐Based Combination Therapies to Boost Cancer Photoimmunotherapy

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Near-infrared (NIR) activated photosensitizers based on heavy-atom-free have great advantages in photoimmunotherapy, yet the tumor microenvironment often restricts their efficacy. To address this, a NIR-activated photosensitizer (named Cy-BF) is developed. Cy-BF then encapsulated with phospholipids and platelet exosome vesicles to create exosomes biomimetic loaded hybrid liposomes CHL) Characterized by high phototoxicity, low dark toxicity, enhanced targeting, CHL demonstrates aggregation-induced broadening of absorption spectra NIR (760 nm laser) activates photothermal therapy type I photodynamic therapy. The CHL-mediated phototherapy induces mitochondrial damage immunogenic cell death cells, decreases lactate production, alters reducing regulatory T cells increasing CD8+ cells. mitigate inhibition excess lactate, combination introduced using lithium carbonate, which repurposes as an energy source for thereby enhancing effectiveness photoimmunotherapy. This approach represents novel strategy reversing metabolism both paving way future clinical applications

Language: Английский

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Multifunctional glycyrrhizic acid-loaded nanoplatform combining ferroptosis induction and HMGB1 blockade for enhanced tumor immunotherapy

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 19, 2025

Inducing ferroptotic cell death has been recognized as a promising approach in cancer therapy. However, ferroptosis can provoke tumor infiltration by myeloid-derived suppressor cells (MDSCs) through HMGB1 secretion, causing suppressive immune response. On the other hand, also occurs due to its non-selective properties, which compromise anti-tumor immunity. To address these challenges, two-pronged is proposed, encompassing selectively triggered and blockade, aimed at eliciting systemic immunity alleviating immunosuppression. Herein, GSH-specific driven nanoplatform composed of uniform FeOOH nanospindles coated with tetrasulfide bond-bridged mesoporous organosilica (DMOS) shell, loaded inhibitor, glycyrrhizic acid (GA). This endowed high glutathione (GSH) depletion efficiency exhibits highly efficient Fe2+ ROS generation capacity, promotes accumulation LPO subsequently induces ferroptosis. Concurrently, inhibition release counteracts immunosuppressive effects within microenvironment. innovative effectively suppresses growth 4T1 tumors notably enhancing therapeutic outcomes checkpoint blockade across experimental data. The collective findings indicate potential reliable strategy for boosting ferroptosis-mediated favorable safety profiles.

Language: Английский

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Closed-loop cascade nanozyme strategy for mutually reinforced catalytic and mild-temperature photothermal therapeutic effects

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 4, 2025

Nanocatalysis coupled with photothermal therapy is a potent anti-cancer approach, yet its clinical utility limited by low concentration of tumor substrate, redox interference, and risks overheating normal tissues. Herein, we propose an innovative closed-loop nanozyme approach that leverages the synergistic effects catalytic mild (mPTT) to address aforementioned challenges. The strategy features folic acid-functionalized iron single-atom catalyst (FeNC-FA), designed exhibit exceptional multienzymatic capabilities optimal response. In system, engineered FeNC-FA capable inducing reactive oxygen species (ROS) storm depleting glutathione (GSH) in specific microenvironment (TME) initiate ferroptosis. Concurrently, accumulation ROS effectively cleaves heat shock proteins (HSPs), thereby enhancing mPTT. An intriguing aspect increased temperature within TME further facilitates conversion H2O2 O2, alleviating hypoxia providing positive feedback circuit boost therapy. Additionally, advanced photoacoustic (PA) imaging allow for self-monitoring their at sites, guiding mPTT process. Taken together, it provides PA image-guided, mutually reinforced both vitro vivo. This targeted holds great promise personalized medicine applications.

Language: Английский

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Nanosensitizer-assisted sonodynamic therapy for breast cancer

Journal of Nanobiotechnology, Journal Year: 2025, Volume and Issue: 23(1)

Published: April 7, 2025

Abstract Breast cancer is the most commonly diagnosed worldwide. Despite advancements in therapeutic modalities, its prognosis remains poor owing to complex clinical, pathological, and molecular characteristics. Sonodynamic therapy (SDT) a promising approach for tumor elimination, using sonosensitizers that preferentially accumulate tissues are activated by low-intensity ultrasound produce reactive oxygen species. However, clinical translation of SDT faces challenges, including limited efficiency resistance posed microenvironment. The emergence nanomedicine offers innovative strategies address these obstacles. This review discusses enhancing efficacy sonosensitizers, rational structural modifications, improved tumor-targeted enrichment, microenvironment remodeling, imaging-guided therapy. Additionally, SDT-based multimodal therapies, such as sono-chemotherapy, sono-immunotherapy, sono-photodynamic therapy, their potential applications breast treatment summarized. underlying mechanisms briefly outlined. Finally, this highlights current challenges prospects SDT, providing insights into future may improve outcomes cancer. Graphical abstract

Language: Английский

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Reduced graphene oxide quantum dots/manganese dioxide/glucose oxidase nanoparticles for cascade catalytic cancer treatment in multimodal starvation therapy-augmented chemodynamic/photothermal therapy

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114713 - 114713

Published: April 1, 2025

Language: Английский

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Augment of Ferroptosis with Photothermal Enhanced Fenton Reaction and Glutathione Inhibition for Tumor Synergistic Nano-Catalytic Therapy

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 11923 - 11940

Published: Nov. 1, 2024

Ferroptosis-driven tumor ablation strategies based on nanotechnology could be achieved by elevating intracellular iron levels or inhibiting glutathione peroxidase 4 (GPX4) activity. However, the antioxidative defense mechanisms endow cells with ferroptosis resistance capacity. The purpose of this study was to develop a synergistic therapeutic platform enhance efficacy ferroptosis-based therapy. In study, multifunctional nano-catalytic (mFeB@PDA-FA) chemodynamic therapy (CDT) and photothermal (PTT) developed effectively trigger in tumor. our work, iron-based mesoporous Fe3O4 nanoparticles (mFe3O4 NPs) were employed for encapsulation L-buthionine sulfoximine (BSO), followed modification folic acid-functionalized polydopamine (PDA) coating periphery. Then, antitumor effect mFeB@PDA-FA NPs evaluated using Human OS (MNNG/HOS) subcutaneous xenograft model osteosarcoma. mFe3O4 harboring multivalent elements (Fe2+/3+) catalyze hydrogen peroxide (H2O2) into highly cytotoxic ˙OH, while microenvironment (TME)-responsive released BSO molecules inhibit biosynthesis GSH, thus achieving deactivation GPX4 enhancement ferroptosis. Moreover, thanks remarkable conversion performance PDA shell, PTT further synergistically enhanced CDT facilitated Both vivo vitro experiments confirmed that achieve excellent inhibition effects. nanotherapeutic disrupted redox homeostasis boosting through combination CDT, GSH elimination, which provided new perspective treatment sensitive tumors.

Language: Английский

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Design of Nanocrystalline Suspension of Dutasteride for Intramuscular Prolonged Delivery

Nanomaterials, Journal Year: 2024, Volume and Issue: 14(22), P. 1781 - 1781

Published: Nov. 5, 2024

The aim of the study is to formulate an injectable nanocrystalline suspension (NS) dutasteride (DTS), a hydrophobic 5α-reductase inhibitor used treat benign prostatic hyperplasia and scalp hair loss, for parenteral long-acting delivery. A DTS-loaded NS (DTS-NS, 40 mg/mL DTS) was prepared using lab-scale bead-milling technique. optimized DTS-NS Tween 80 (0.5%

Language: Английский

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