MedComm, Journal Year: 2025, Volume and Issue: 6(5)

Published: April 28, 2025

ABSTRACT Molecular hydrogen (H 2 ), recognized as the smallest gas molecule, is capable of permeating cellular membranes and diffusing throughout body. Due to its high bioavailability, H considered a therapeutic for treatment various diseases. The efficacy contingent upon factors such administration method, duration contact with diseased tissue, concentration at targeted sites. can be administered exogenously also produced endogenously within intestinal tract. A comprehensive understanding delivery mechanisms modes action crucial advancing medicine. This review highlights H₂’s action, summarizes methods, explores advancements in treating diseases (e.g., inflammatory bowel disease, ischemia–reperfusion, colorectal cancer). Additionally, applications managing other are discussed. Finally, challenges associated clinical application potential solutions explored. We propose that current faced by effectively addressed through use nanoplatforms; furthermore, interactions between gut microbiota may provide insights into Future research should explore synergistic effects conjunction conventional therapies develop personalized plans achieve precision

Language: Английский