Application of Nanomaterial-Mediated Ferroptosis Regulation in Kidney Disease DOI Creative Commons
Jiamin Zhu, Zhen Zhang,

Yanhui Chu

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 1637 - 1659

Published: Feb. 1, 2025

Abstract: Kidney diseases are a significant global cause of death and disability, resulting from the destruction kidney structure function due to an imbalance between renal parenchymal cells proliferation or recruitment maladaptive cells, caused by various pathogenic factors. Currently, therapies their efficacy for limited. Ferroptosis is newly discovered iron-dependent regulated cell death. The iron homeostasis lipid metabolism affects occurrence progression triggering ferroptosis, which considered important target development disease drugs. However, in clinical practice, targeted ferroptosis therapy faces obstacles such as poor drug solubility, low resistance, imprecise targeting. With rapid nanomaterials medical field, new opportunities have emerged precise regulation treatment diseases. This article provides detailed introduction regulatory mechanisms properties nanomaterials, application diseases, with focus on discussing action therapeutic potential based aim this provide ideas directions future treatments. Keywords: nanomaterial, nanomedicine,

Language: Английский

Application of Nanomaterial-Mediated Ferroptosis Regulation in Kidney Disease DOI Creative Commons
Jiamin Zhu, Zhen Zhang,

Yanhui Chu

et al.

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 1637 - 1659

Published: Feb. 1, 2025

Abstract: Kidney diseases are a significant global cause of death and disability, resulting from the destruction kidney structure function due to an imbalance between renal parenchymal cells proliferation or recruitment maladaptive cells, caused by various pathogenic factors. Currently, therapies their efficacy for limited. Ferroptosis is newly discovered iron-dependent regulated cell death. The iron homeostasis lipid metabolism affects occurrence progression triggering ferroptosis, which considered important target development disease drugs. However, in clinical practice, targeted ferroptosis therapy faces obstacles such as poor drug solubility, low resistance, imprecise targeting. With rapid nanomaterials medical field, new opportunities have emerged precise regulation treatment diseases. This article provides detailed introduction regulatory mechanisms properties nanomaterials, application diseases, with focus on discussing action therapeutic potential based aim this provide ideas directions future treatments. Keywords: nanomaterial, nanomedicine,

Language: Английский

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